Generic and additional names: CAS name: 2-(Aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]- tetrahydropyran-3,4,5-triol CAS registry #: 8063-07-8 Molecular formula: C18H36N4O11 Molecular weight: 582.58 Intellect...
Generic and additional names: CAS name: 2-(Aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]- tetrahydropyran-3,4,5-triol CAS registry #: 8063-07-8 Molecular formula: C18H36N4O11 Molecular weight: 582.58 Intellectual property rights: Generic Brand names: Aminodeoxykanamycin, Bekanamycin, Kanamycin A, Kanamycin B, Kanamycin Base, Kanamycin Sulfate, Kantrex, Kenamycin A, Klebcil, Nebramycin Factor 5 Derivatives: Kanamycin A, Kanamycin B, Kanamycin C Solubility: Kanamycin A sulfate is freely soluble in water. Practically insoluble in the common alcohols and nonpolar solvents. Kanamycin B–Bekanamycin, aminodeoxykanamycin is–soluble in water, formamide; slightly soluble in chloroform, isopropyl alcohol; practically insoluble in the common alcohols and nonpolar solvents. Kanamycin C is soluble in water; slightly soluble in formamide; practically insoluble in the common alcohols and nonpolar solvents [Merck Index]. Polarity: Log P −7.936 [DrugBank] Formulation and optimal human dosage: 1 g vial, dose 1 g daily i.v. or intramuscularly (i.m.)1
Generic and additional names: CAS name: 2-(Aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]- tetrahydropyran-3,4,5-triol CAS registry #: 8063-07-8 Molecular formula: C18H36N4O11 Molecular weight: 582.58 Intellectual property rights: Generic Brand names: Aminodeoxykanamycin, Bekanamycin, Kanamycin A, Kanamycin B, Kanamycin Base, Kanamycin Sulfate, Kantrex, Kenamycin A, Klebcil, Nebramycin Factor 5 Derivatives: Kanamycin A, Kanamycin B, Kanamycin C Solubility: Kanamycin A sulfate is freely soluble in water. Practically insoluble in the common alcohols and nonpolar solvents. Kanamycin B–Bekanamycin, aminodeoxykanamycin is–soluble in water, formamide; slightly soluble in chloroform, isopropyl alcohol; practically insoluble in the common alcohols and nonpolar solvents. Kanamycin C is soluble in water; slightly soluble in formamide; practically insoluble in the common alcohols and nonpolar solvents [Merck Index]. Polarity: Log P −7.936 [DrugBank] Formulation and optimal human dosage: 1 g vial, dose 1 g daily i.v. or intramuscularly (i.m.)1
참고문헌 (6)
Chan 773 2003 Tuberculosis Pyrazinamide, ethambutol, ethionamide, and aminoglycosides
J Antimicrob Chemother Di Perri 54 593 2004 10.1093/jac/dkh377 Which agents should we use for the treatment of multidrug-resistant Mycobacterium tuberculosis?
Curr Microbiol Rastogi 33 167 1996 10.1007/s002849900095 In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages
Antimicrob Agents Chemother Lounis 41 607 1996 10.1128/AAC.41.3.607 Which aminoglycoside or fluoroquinolone is more active against Mycobacterium tuberculosis in mice?
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