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Anticancer activity of lactoferrin isolated from caprine colostrum on human cancer cell lines

International journal of dairy technology, v.62 no.2, 2009년, pp.277 - 281  

KIM, YOUNGHOON (Division of Food Bioscience and Technology, College of Life Science and Biotechnology, Korea University, Seoul 136-701, South Korea) ,  KIM, MAE JIN (Division of Food Bioscience and Technology, College of Life Science and Biotechnology, Korea University, Seoul 136-701, South Korea) ,  HAN, KYOUNG SIK (Riddet Centre, Massey University, Private Bag 11 ) ,  IMM, JEE YOUNG (222, Palmerston North, New Zealand) ,  OH, SEJONG (Department of Food and Nutrition, Kookmin University, Seoul 136-702, South Korea) ,  KIM, SAE HUN (Department of Animal Science, Chonnam National University, Gwangju 500-757, South Korea)

Abstract AI-Helper 아이콘AI-Helper

In the present study, lactoferrin was purified from caprine colostrum and its anticancer effects were investigated on various cancer cell lines, including lung, colon, cervix, stomach and breast cancer cells. The caprine lactoferrin (CLF) was purified by ultrafiltration and sequential chromatography...

주제어

참고문헌 (16)

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  3. Damiens, Eve, El Yazidi, Ikram, Mazurier, Joël, Elass-Rochard, Elisabeth, Duthille, Isabelle, Spik, Geneviève, Boilly-Marer, Yolande. Role of heparan sulphate proteoglycans in the regulation of human lactoferrin binding and activity in the MDA-MB-231 breast cancer cell line. European journal of cell biology, vol.77, no.4, 344-351.

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  5. Kimura, Michito, Nam, Myoung-Soo, Ohkouchi, Yoshifumi, Kumura, Haruto, Shimazaki, Kei-ichi, Yu, Dea-Youl. Antimicrobial Peptide of Korean Native Goat Lactoferrin and Identification of the Part Essential for This Activity. Biochemical and biophysical research communications, vol.268, no.2, 333-336.

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  9. Korean Journal of Dairy Science Nam M S 289 18 1996 Lactoferrin: a review 

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  11. PIERCE, Annick, COLAVIZZA, Didier, BENAISSA, Monique, MAES, Pierrette, TARTAR, André, MONTREUIL, Jean, SPIK, Geneviève. Molecular cloning and sequence analysis of bovine lactotransferrin. European journal of biochemistry, vol.196, no.1, 177-184.

  12. Recio, Isidra, Visser, Servaas. Two ion-exchange chromatographic methods for the isolation of antibacterial peptides from lactoferrin : In situ enzymatic hydrolysis on an ion-exchange membrane. Journal of chromatography A, vol.831, no.2, 191-201.

  13. Sekine, Kazunori, Ushida, Yoshihiko, Kuhara, Tetsuya, Iigo, Masaaki, Baba-Toriyama, Hiroyasu, Moore, Malcolm A, Murakoshi, Michiaki, Satomi, Yoshiko, Nishino, Hoyoku, Kakizoe, Tadao, Tsuda, Hiroyuki. Inhibition of initiation and early stage development of aberrant crypt foci and enhanced natural killer activity in male rats administered bovine lactoferrin concomitantly with azoxymethane. Cancer letters, vol.121, no.2, 211-216.

  14. Shimazaki, K., Tazume, T., Uji, K., Tanaka, M., Kumura, H., Mikawa, K., Shimo-oka, T.. Properties of a Heparin-binding Peptide Derived from Bovine Lactoferrin. Journal of dairy science, vol.81, no.11, 2841-2849.

  15. Ward, P. P., Paz, E., Conneely, O. M.. Lactoferrin : Multifunctional roles of lactoferrin: a critical overview. Cellular and molecular life sciences : CMLS, vol.62, no.22, 2540-2548.

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