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Abstract ▼ AI-Helper

Purpose: To determine the relationship between the pulmonary function test (PFT) and the optimal threshold value for the emphysema index at volumetric CT in chronic obstructive lung disease (COPD). Materials and Methods: Volumetric CT scans were performed in 53 patients with COPD at inspiration and ...

Purpose: To determine the relationship between the pulmonary function test (PFT) and the optimal threshold value for the emphysema index at volumetric CT in chronic obstructive lung disease (COPD). Materials and Methods: Volumetric CT scans were performed in 53 patients with COPD at inspiration and expiration using the same CT scanner. By using the in-house software, the emphysema index, which included the threshold value between -700 and -990 HU, was calculated automatically. The data were analyzed by calculating the Pearson correlation coefficient between each set of CT data and the forced expiratory volume occurring over 1 second (FEV1), the forced expiratory volume occurring over 1 second over the vital capacity ratio (FEV1/FVC), and the diffusion capacity of carbon monoxide (DLco). Results: The strongest correlation between FEV1 and FEV1/FVC was found to have a threshold of -940 HU at inspiration and -910 HU during an expiration CT scan. The strongest correlation with DLco was observed with a threshold of -970 HU at inspiration and -960 HU at expiration. Conclusion: The threshold showing the best correlation with the PFT parameters was variable. As for the inspiration CT scan, the threshold area, showing a relatively good correlation with PFT, occurred over -940 to -970 HU. Hence, it is pertinent that -950 HU or -960 HU was a common benchmark used for threshold of the emphysema index.

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