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Abstract ▼ AI-Helper

Unknown causes of liver cirrhosis continue to be on the decrease after advances in viral, genetic, and immunological testing. Recently, it has been reported that patients with hypopituitarism may have non-alcoholic steatohepatitis and liver,cirrhosis. We report here a case of 48-year-old woman with ...

Unknown causes of liver cirrhosis continue to be on the decrease after advances in viral, genetic, and immunological testing. Recently, it has been reported that patients with hypopituitarism may have non-alcoholic steatohepatitis and liver,cirrhosis. We report here a case of 48-year-old woman with hypopituitarism who developed cryptogenic liver cirrhosis. The patient received insulin therapy for diabetes mellitus for 23 years. About 20 years ago, she also took medication for pulmonary tuberculosis. On physical examination, she showed no secondary sexual expression. On laboratory findings, there was pancytopenia. Markers for hepatitis B and C, autoimmune liver disease, iron overload and α-1-antitrypsin deficiency were all negative. The level of leptin was increased. A pituitary stimulation test showed a decrease of growth hormone, cortisol, ACTH, prolactin, LH, and FSH; the level of TSH was normal. Abdominal ultrasonography showed a cirrhotic liver with ascites and splenomegaly. A brain MRI showed a non-clearly identified pituitary gland of a severely decreased volume. On esophagogastroduodenoscopy, the presence of esophageal varices indicated portal hypertension. All these findings suggest that the patient has a diagnosis of cryptogenic liver cirrhosis with hypopituitarism.

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