$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Ascorbic acid accelerates osteoclast formation and death

Bone, v.46 no.5, 2010년, pp.1336 - 1343  

Le Nihouannen, D. ,  Barralet, J.E. ,  Fong, J.E. ,  Komarova, S.V.

Abstract AI-Helper 아이콘AI-Helper

Ascorbic acid (AA) plays a key role in bone formation. However controversy remains about the effect of AA on cells responsible for bone destruction, osteoclasts. We investigated the effect of AA on osteoclastogenesis using primary mouse bone marrow cultures and monocytic RAW 264.7 cells treated with...

주제어

참고문헌 (50)

  1. Nature Kong 397 315 1999 10.1038/16852 OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis 

  2. J. Clin. Invest. Teng 106 R59 2000 10.1172/JCI10763 Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection 

  3. Prog. Brain Res. Honore 129 389 2000 10.1016/S0079-6123(00)29030-4 Cellular and neurochemical remodeling of the spinal cord in bone cancer pain 

  4. Proc. Natl. Acad. Sci. U. S. A. Pearse 98 11581 2001 10.1073/pnas.201394498 Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression 

  5. Nature Boyle 423 337 2003 10.1038/nature01658 Osteoclast differentiation and activation 

  6. Ann. Rheum. Dis. Jones 61 Suppl. 2 ii32 2002 10.1136/ard.61.suppl_2.ii32 Role of RANKL and RANK in bone loss and arthritis 

  7. Cell Death Differ. Huh 13 1138 2006 10.1038/sj.cdd.4401793 Regulation of osteoclast differentiation by the redox-dependent modulation of nuclear import of transcription factors 

  8. FEBS Lett. Kim 580 5661 2006 10.1016/j.febslet.2006.09.015 Bimodal actions of reactive oxygen species in the differentiation and bone-resorbing functions of osteoclasts 

  9. Exp. Cell Res. Ha 301 119 2004 10.1016/j.yexcr.2004.07.035 Reactive oxygen species mediate RANK signaling in osteoclasts 

  10. J. Clin. Invest. Garrett 85 632 1990 10.1172/JCI114485 Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo 

  11. Biochem. Biophys. Res. Commun. Bax 183 1153 1992 10.1016/S0006-291X(05)80311-0 Stimulation of osteoclastic bone resorption by hydrogen peroxide 

  12. Endocrinology Lean 146 728 2005 10.1210/en.2004-1021 Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation 

  13. Proc. Natl. Acad. Sci. U. S. A. Frei 86 6377 1989 10.1073/pnas.86.16.6377 Ascorbate is an outstanding antioxidant in human blood plasma 

  14. Biochem. Cell. Biol. Padh 68 1166 1990 10.1139/o90-173 Cellular functions of ascorbic acid 

  15. Biochem. Pharmacol. Meister 44 1905 1992 10.1016/0006-2952(92)90091-V On the antioxidant effects of ascorbic acid and glutathione 

  16. FASEB J. Rose 7 1135 1993 10.1096/fasebj.7.12.8375611 Biology of free radical scavengers: an evaluation of ascorbate 

  17. J. Biol. Chem. Nishikimi 269 13685 1994 10.1016/S0021-9258(17)36884-9 Cloning and chromosomal mapping of the human nonfunctional gene for l-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man 

  18. Am. J. Clin. Nutr. Peterkofsky 54 1135S 1991 10.1093/ajcn/54.6.1135s Ascorbate requirement for hydroxylation and secretion of procollagen: relationship to inhibition of collagen synthesis in scurvy 

  19. J. Nutr. Mahmoodian 129 83 1999 10.1093/jn/129.1.83 Vitamin C deficiency in guinea pigs differentially affects the expression of type IV collagen, laminin, and elastin in blood vessels 

  20. J. Invest. Dermatol. Savini 118 372 2002 10.1046/j.0022-202x.2001.01624.x Characterization of keratinocyte differentiation induced by ascorbic acid: protein kinase C involvement and vitamin C homeostasis 

  21. J. Plant. Physiol. Minami 160 475 2003 10.1078/0176-1617-00888 Abscisic acid-induced freezing tolerance in the moss Physcomitrella patens is accompanied by increased expression of stress-related genes 

  22. J. Bone Miner. Res. Franceschi 9 843 1994 10.1002/jbmr.5650090610 Effects of ascorbic acid on collagen matrix formation and osteoblast differentiation in murine MC3T3-E1 cells 

  23. J. Bone Miner. Res. Ragab 13 970 1998 10.1359/jbmr.1998.13.6.970 Osteoclast differentiation requires ascorbic acid 

  24. Endocrinology Otsuka 141 3006 2000 10.1210/endo.141.8.7597 Role of ascorbic acid in the osteoclast formation: induction of osteoclast differentiation factor with formation of the extracellular collagen matrix 

  25. Eur. J. Pharmacol. Takarada 575 1 2007 10.1016/j.ejphar.2007.07.041 Osteoblast protects osteoclast devoid of sodium-dependent vitamin C transporters from oxidative cytotoxicity of ascorbic acid 

  26. J. Endocrinol. Invest. Xiao 28 253 2005 10.1007/BF03345382 Ascorbic acid inhibits osteoclastogenesis of RAW264.7 cells induced by receptor activated nuclear factor kappaB ligand (RANKL) in vitro 

  27. Biochem. Biophys. Res. Commun. Tsuneto 335 1239 2005 10.1016/j.bbrc.2005.08.016 Ascorbic acid promotes osteoclastogenesis from embryonic stem cells 

  28. J. Nutr. Sahni 138 1931 2008 10.1093/jn/138.10.1931 High vitamin C intake is associated with lower 4-year bone loss in elderly men 

  29. Arch. Oral Biol. Sanbe 54 235 2009 10.1016/j.archoralbio.2008.11.001 Vitamin C intake inhibits serum lipid peroxidation and osteoclast differentiation on alveolar bone in rats fed on a high-cholesterol diet 

  30. J. Cell. Sci. Armstrong 122 136 2009 10.1242/jcs.031534 Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts 

  31. Luminescence Koszegi 22 415 2007 10.1002/bio.979 Co-determination of ATP and proteins in Triton X 100 non-ionic detergent-opened monolayer cultured cells 

  32. Proc. Natl. Acad. Sci. U. S. A. Chen 104 8749 2007 10.1073/pnas.0702854104 Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo 

  33. Biochim. Biophys. Acta. Suda 1157 318 1993 10.1016/0304-4165(93)90116-P Participation of oxidative stress in the process of osteoclast differentiation 

  34. Free Radic. Biol. Med. May 39 1449 2005 10.1016/j.freeradbiomed.2005.07.006 Macrophage uptake and recycling of ascorbic acid: response to activation by lipopolysaccharide 

  35. Amino Acids Savini 34 347 2008 10.1007/s00726-007-0555-7 SVCT1 and SVCT2: key proteins for vitamin C uptake 

  36. Free Radic. Biol. Med. Qiao 46 1221 2009 10.1016/j.freeradbiomed.2009.02.004 Macrophage differentiation increases expression of the ascorbate transporter (SVCT2) 

  37. FASEB J. Carr 13 1007 1999 10.1096/fasebj.13.9.1007 Does vitamin C act as a pro-oxidant under physiological conditions? 

  38. J. Am. Coll. Nutr. Padayatty 22 18 2003 10.1080/07315724.2003.10719272 Vitamin C as an antioxidant: evaluation of its role in disease prevention 

  39. Antioxid. Redox Signal. Clement 3 157 2001 10.1089/152308601750100687 The in vitro cytotoxicity of ascorbate depends on the culture medium used to perform the assay and involves hydrogen peroxide 

  40. Cardiovasc. Res. Garry 2009 10.1093/cvr/cvp235 Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide 

  41. J. Cell. Physiol. Steinbeck 176 574 1998 10.1002/(SICI)1097-4652(199809)176:3<574::AID-JCP14>3.0.CO;2-# Involvement of hydrogen peroxide in the differentiation of clonal HD-11EM cells into osteoclast-like cells 

  42. J. Bone Miner. Res. Koh 21 1003 2006 10.1359/jbmr.060406 Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased intracellular ROS generation 

  43. Bone Fraser 19 223 1996 10.1016/8756-3282(96)00177-9 Hydrogen peroxide, but not superoxide, stimulates bone resorption in mouse calvariae 

  44. Biochem. Biophys. Res. Commun. Hall 207 280 1995 10.1006/bbrc.1995.1184 The role of reactive oxygen intermediates in osteoclastic bone resorption 

  45. J. Med. Food Rao 6 69 2003 10.1089/109662003322233459 Lycopene I-effect on osteoclasts: lycopene inhibits basal and parathyroid hormone-stimulated osteoclast formation and mineral resorption mediated by reactive oxygen species in rat bone marrow cultures 

  46. Blood Lee 106 852 2005 10.1182/blood-2004-09-3662 A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation 

  47. Physiol. Rev. Gallop 55 418 1975 10.1152/physrev.1975.55.3.418 Posttranslational protein modifications, with special attention to collagen and elastin 

  48. J. Biol. Chem. Dunn 259 10764 1984 10.1016/S0021-9258(18)90577-6 Carnitine biosynthesis from gamma-butyrobetaine and from exogenous protein-bound 6-N-trimethyl-l-lysine by the perfused guinea pig liver. Effect of ascorbate deficiency on the in situ activity of gamma-butyrobetaine hydroxylase 

  49. Am. J. Clin. Nutr. Rebouche 54 1147S 1991 10.1093/ajcn/54.6.1147s Ascorbic acid and carnitine biosynthesis 

  50. Am. J. Physiol. Cell Physiol. Oursler 288 C156 2005 10.1152/ajpcell.00092.2004 Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis 

관련 콘텐츠

이 논문과 함께 이용한 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로