Kim, Hyun Kyung
,
Jung, Hae-Yun
,
Lim, Seungjoon
,
Sung, Jae Sook
,
Whang, Young Mi
,
Jo, Ukhyun
,
Lee, Jong Eun
,
Shin, Sang Won
,
Kim, Jun Suk
,
Ryu, Jeong Seon
,
Kim, Yeul Hong
Background/Aim: This study examined whether the polymorphisms at the promoter region of RET gene are associated with the risk of lung cancer in the Korean population. PATIENTS AND METHODS: A total of 409 Korean lung cancer patients and 409 normal subjects were recruited. PCR-RFLP, SNaP Shot assay an...
Background/Aim: This study examined whether the polymorphisms at the promoter region of RET gene are associated with the risk of lung cancer in the Korean population. PATIENTS AND METHODS: A total of 409 Korean lung cancer patients and 409 normal subjects were recruited. PCR-RFLP, SNaP Shot assay and logistic regression analyses were performed to characterize the association between polymorphisms of RET and lung cancer risk. RESULTS: Four SNPs (-1697 C>G, -1260 C>T, -719 C>T, -527 C>A) of RET were selected for large-scale genotyping. Statistical analyses revealed that novel -1260 C > T polymorphism and haplotype 3 (-1697G, -1260T, -719C, and -719C) were associated with the risk of lung cancer; specifically, there were significant associations within subgroups of males and smokers. CONCLUSION: These results demonstrated that this novel polymorphism of the RET gene is associated with an increased risk of lung cancer in the Korean population.
Background/Aim: This study examined whether the polymorphisms at the promoter region of RET gene are associated with the risk of lung cancer in the Korean population. PATIENTS AND METHODS: A total of 409 Korean lung cancer patients and 409 normal subjects were recruited. PCR-RFLP, SNaP Shot assay and logistic regression analyses were performed to characterize the association between polymorphisms of RET and lung cancer risk. RESULTS: Four SNPs (-1697 C>G, -1260 C>T, -719 C>T, -527 C>A) of RET were selected for large-scale genotyping. Statistical analyses revealed that novel -1260 C > T polymorphism and haplotype 3 (-1697G, -1260T, -719C, and -719C) were associated with the risk of lung cancer; specifically, there were significant associations within subgroups of males and smokers. CONCLUSION: These results demonstrated that this novel polymorphism of the RET gene is associated with an increased risk of lung cancer in the Korean population.
이 논문을 인용한 문헌
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
활용도 분석정보
상세보기
다운로드
내보내기
활용도 Top5 논문
해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다. 더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.
LOADING...
관련 콘텐츠
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.