[논문]Molecular Epidemiology of Female Lung Cancer

Yim, Seon-Hee; Chung, Yeun-Jun

doi:10.3390/cancers3021861

[해외논문] Molecular Epidemiology of Female Lung Cancer 원문보기

Cancers, v.3 no.2, 2011년, pp.1861 - 1876

Yim, Seon-Hee (Integrated Research Center for Genome Polymorphism, The Catholic University of Korea School of Medicine, 505 Banpo-dong, Seocho-gu, Seoul 137-701, Korea) , Chung, Yeun-Jun (E-Mail: lyra@catholic.ac.kr)

Abstract ▼ AI-Helper

Lung cancer is still a leading cause of cancer mortality in the world. The incidence of lung cancer in developed countries started to decrease mainly due to global anti-smoking campaigns. However, the incidence of lung cancer in women has been increasing in recent decades for various reasons. Furthermore, since the screening of lung cancer is not as yet very effective, clinically applicable molecular markers for early diagnosis are much required. Lung cancer in women appears to have differences compared with that in men, in terms of histologic types and susceptibility to environmental risk factors. This suggests that female lung cancer can be derived by carcinogenic mechanisms different from those involved in male lung cancer. Among female lung cancer patients, many are non-smokers, which could be studied to identify alternative carcinogenic mechanisms independent from smoking-related ones. In this paper, we reviewed molecular susceptibility markers and genetic changes in lung cancer tissues observed in female lung cancer patients, which have been validated by various studies and will be helpful to understand the tumorigenesis of lung cancer.

Keyword

참고문헌 (88)

1. IARC GLOBOCAN 2008 http://globocan.iarc.fr/ (accessed on 1 December 2010)
2. Kiyohara C. Ohno Y. Sex differences in lung cancer susceptibility: A review Gend Med. 2010 7 381 401 21056866
3. Lubin J.H. Blot W.J. Assessment of lung cancer risk factors by histologic category J. Natl. Cancer Inst. 1984 73 383 389 6087006
4. Toh C.K. The changing epidemiology of lung cancer Methods Mol. Biol. 2009 472 397 411 19107445

상세보기
5. Stellman S.D. Muscat J.E. Thompson S. Hoffmann D. Wynder E.L. Risk of squamous cell carcinoma and adenocarcinoma of the lung in relation to lifetime filter cigarette smoking Cancer 1997 80 382 388 9241071
6. Thun M.J. Lally C.A. Flannery J.T. Calle E.E. Flanders W.D. Heath C.W. Jr. Cigarette smoking and changes in the histopathology of lung cancer J. Natl. Cancer Inst. 1997 89 1580 1586 9362155

상세보기
7. Egleston B.L. Meireles S.I. Flieder D.B. Clapper M.L. Population-based trends in lung cancer incidence in women Semin. Oncol. 2009 36 506 515 19995642

상세보기
8. Brownson R. Chang J. Davis J. Gender and histologic type cariations in smoking-related risk of lung cancer Epidemiology 1992 3 61 64 1313311
9. Risch H.A. Howe G.R. Jain M. Burch J.D. Holowaty E.J. Miller A.B. Are female smokers at higher risk for lung cancer than male smokers? A case-control analysis by histologic type Am. J. Epidemiol. 1993 138 281 293 8395141

상세보기
10. Harris R.E. Zang E.A. Anderson J.I. Wynder E.L. Race and sex differences in lung cancer risk associated with cigarette smoking Int. J. Epidemiol 1993 22 592 599 8225730

상세보기
11. Zang E.A. Wynder E.L. Differences in lung cancer risk between men and women: Examination of the evidence J. Natl. Cancer Inst. 1996 88 183 192 8632492
12. Prescott E. Osier M. Rein H.O. Borch-Johnsen K. Lange P. Schnohr P. Vestbo J. Gender and smoking-related risk of lung cancer. The Copenhagen Center for Prospective Population Studies Epidemiology 1998 9 79 83 9430273
13. Bain C. Feskanich D. Speizer F.E. Thun M. Hertzmark E. Rosner B.A. Colditz G.A. Lung cancer rates in men and women with comparable histories of smoking J. Natl. Cancer Inst. 2004 96 826 834 15173266

상세보기
14. Paggi M.G. Vona R. Abbruzzese C. Malorni W. Gender-related disparities in non-small cell lung cancer Cancer Lett. 2010 298 1 8 20826048

상세보기
15. Roos P.H. Bolt H.M. Cytochrome P450 interactions in human cancers: new aspects considering CYP1B1 Expert Opin. Drug Metab. Toxicol. 2005 1 187 202 16922636
16. Gasperino J. Gender is a risk factor for lung cancer Med. Hypotheses 2011 76 328 331 21106301

상세보기
17. Hecht S.S. Tobacco smoke carcinogens and lung cancer J. Natl. Cancer Inst. 1999 91 1194 1210 10413421

상세보기
18. Meyer U.A. Overview of enzymes of drug metabolism J. Pharmacokinet. Biopharm. 1996 24 449 459 9131484

상세보기
19. Tang D.L. Rundle A. Warburton D. Santella R.M. Tsai W.Y. Chiamprasert S. Hsu Y.Z. Perera F.P. Associations between both genetic and environmental biomarkers and lung cancer: evidence of a greater risk of lung cancer in women smokers Carcinogenesis 1998 19 1949 1953 9855008

상세보기
20. Dresler C.M. Fratelli C. Babb J. Everley L. Evans A.A. Clapper M.L. Gender differences in genetic susceptibility for lung cancer Lung Cancer 2000 30 153 160 11137199
21. Ye Z. Song H. Higgins J.P. Pharoah P. Danesh J. Five glutathione s-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls: Meta-analysis of 130 studies PLoS Med. 2006 3 e91 16509765

상세보기
22. Hung R.J. Boffetta P. Brockmoller J. Butkiewicz D. Cascorbi I. Clapper M.L. Garte S. Haugen A. Hirvonen A. Anttila S. Kalina I. Le Marchand L. London S.J. Rannug A. Romkes M. Salagovic J. Schoket B. Gaspari L. Taioli E. CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: A pooled analysis Carcinogenesis 2003 24 875 882 12771031

상세보기
23. Le Marchand L. Guo C. Benhamou S. Bouchardy C. Cascorbi I. Clapper M.L. Garte S. Haugen A. Ingelman-Sundberg M. Kihara M. Rannug A. Ryberg D. Stucker I. Sugimura H. Taioli E. Pooled analysis of the CYP1A1 exon 7 polymorphism and lung cancer (United States) Cancer Causes Control 2003 14 339 346 12846365

상세보기
24. Timofeeva M.N. Kropp S. Sauter W. Beckmann L. Rosenberger A. Illig T. Jager B. Mittelstrass K. Dienemann H. Bartsch H. Bickeboller H. Chang-Claude J.C. Risch A. Wichmann H.E. CYP450 polymorphisms as risk factors for early-onset lung cancer: gender-specific differences Carcinogenesis 2009 30 1161 1169 19414505

상세보기
25. Wang Y. Yang H. Li L. Wang H. Zhang C. Yin G. Zhu B. Association between CYP2E1 genetic polymorphisms and lung cancer risk: a meta-analysis Eur. J. Cancer 2010 46 758 764 20031389

상세보기
26. Langevin S.M. Ioannidis J.P. Vineis P. Taioli E. Assessment of cumulative evidence for the association between glutathione S-transferase polymorphisms and lung cancer: application of the Venice interim guidelines Pharmacogenet Genomics 2010 20 586 597 20729793

상세보기
27. Cote M.L. Chen W. Smith D.W. Benhamou S. Bouchardy C. Butkiewicz D. Fong K.M. Gene M. Hirvonen A. Kiyohara C. Larsen J.E. Lin P. Raaschou-Nielsen O. Povey A.C. Reszka E. Risch A. Schneider J. Schwartz A.G. Sorensen M. To-Figueras J. Tokudome S. Pu Y. Yang P. Wenzlaff A.S. Wikman H. Taioli E. Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: a HuGE-GSEC review Am. J. Epidemiol. 2009 169 802 814 19240225

상세보기
28. Hosgood H.D. 3rd Berndt S.I. Lan Q. GST genotypes and lung cancer susceptibility in Asian populations with indoor air pollution exposures: a meta-analysis Mutat. Res. 2007 636 134 143 17428724
29. Timofeeva M. Kropp S. Sauter W. Beckmann L. Rosenberger A. Illig T. Jager B. Mittelstrass K. Dienemann H. Bartsch H. Bickeboller H. Chang-Claude J. Risch A. Wichmann H.E. Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer Int. J. Cancer 2010 127 1547 1561 20091863

상세보기
30. Cote M.L. Yoo W. Wenzlaff A.S. Prysak G.M. Santer S.K. Claeys G.B. Van Dyke A.L. Land S.J. Schwartz A.G. Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women Carcinogenesis 2009 30 626 635 19174490

상세보기
31. Yang M. Choi Y. Hwangbo B. Lee J.S. Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility Lung Cancer 2007 57 135 142 17428572
32. Cote M.L. Kardia S.L. Wenzlaff A.S. Land S.J. Schwartz A.G. Combinations of glutathione S-transferase genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study Carcinogenesis 2005 26 811 819 15661806

상세보기
33. Miller D.P. Neuberg D. de Vivo I. Wain J.C. Lynch T.J. Su L. Christiani D.C. Smoking and the risk of lung cancer: susceptibility with GSTP1 polymorphisms Epidemiology 2003 14 545 551 14501269

상세보기
34. Kiyohara C. Yamamura K.I. Nakanishi Y. Takayama K. Hara N. Polymorphism in GSTM1, GSTT1, and GSTP1 and Susceptibility to Lung Cancer in a Japanese Population Asian Pac. J. Cancer Prev. 2000 1 293 298 12716303

상세보기
35. Taioli E. Benhamou S. Bouchardy C. Cascorbi I. Cajas-Salazar N. Dally H. Fong K.M. Larsen J.E. Le Marchand L. London S.J. Risch A. Spitz M.R. Stucker I. Weinshenker B. Wu X. Yang P. Myeloperoxidase G-463A polymorphism and lung cancer: a HuGE genetic susceptibility to environmental carcinogens pooled analysis Genet. Med. 2007 9 67 73 17304047

상세보기
36. Yoon K.A. Kim J.H. Gil H.J. Hwang H. Hwangbo B. Lee J.S. CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women Lung Cancer 2008 60 40 46 17980933
38. Wang H. Jin G. Liu G. Qian J. Jin L. Wei Q. Shen H. Huang W. Lu D. Genetic susceptibility of lung cancer associated with common variants in the 3′ untranslated regions of the adenosine triphosphate-binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for carcinogen export Cancer 2009 115 595 607 19107762
39. Berwick M. Vineis P. Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review J. Natl. Cancer. Inst. 2000 92 874 897 10841823

상세보기
40. Wei Q. Cheng L. Amos C.I. Wang L.E. Guo Z. Hong W.K. Spitz M.R. Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study J. Natl. Cancer Inst. 2000 92 1764 1772 11058619

상세보기
41. Mooney L.A. Perera F.P. Van Bennekum A.M. Blaner W.S. Karkoszka J. Covey L. Hsu Y. Cooper T.B. Frenkel K. Gender differences in autoantibodies to oxidative DNA base damage in cigarette smokers Cancer Epidemiol. Biomarkers Prev. 2001 10 641 648 11401914
42. Kaina B. Christmann M. Naumann S. Roos W.P. MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents DNA Repair (Amst.) 2007 6 1079 1099 17485253

상세보기
43. Licchesi J.D. Westra W.H. Hooker C.M. Herman J.G. Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung Clin. Cancer Res. 2008 14 2570 2578 18451218

상세보기
44. Esteller M. Hamilton S.R. Burger P.C. Baylin S.B. Herman J.G. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia Cancer Res. 1999 59 793 797 10029064

상세보기
45. Zochbauer-Muller S. Fong K.M. Virmani A.K. Geradts J. Gazdar A.F. Minna J.D. Aberrant promoter methylation of multiple genes in non-small cell lung cancers Cancer Res. 2001 61 249 255 11196170

상세보기
46. Uccella S. Cerutti R. Placidi C. Marchet S. Carnevali I. Bernasconi B. Proserpio I. Pinotti G. Tibiletti M.G. Furlan D. Capella C. MGMT methylation in diffuse large B-cell lymphoma: validation of quantitative methylation-specific PCR and comparison with MGMT protein expression J. Clin. Pathol. 2009 62 715 723 19638543

상세보기
47. Wu J.Y. Wang J. Lai J.C. Cheng Y.W. Yeh K.T. Wu T.C. Chen C.Y. Lee H. Association of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation with p53 mutation occurrence in non-small cell lung cancer with different histology, gender, and smoking status Ann. Surg. Oncol. 2008 15 3272 3277 18712569

상세보기
48. Kaur T.B. Travaline J.M. Gaughan J.P. Richie J.P. Jr. Stellman S.D. Lazarus P. Role of polymorphisms in codons 143 and 160 of the O6-alkylguanine DNA alkyltransferase gene in lung cancer risk Cancer Epidemiol. Biomarkers Prev. 2000 9 339 342 10750675
49. Krzesniak M. Butkiewicz D. Samojedny A. Chorazy M. Rusin M. Polymorphisms in TDG and MGMT genes - epidemiological and functional study in lung cancer patients from Poland Ann. Hum. Genet. 2004 68 300 312 15225156

상세보기
50. Cohet C. Borel S. Nyberg F. Mukeria A. Bruske-Hohlfeld I. Constantinescu V. Benhamou S. Brennan P. Hall J. Boffetta P. Exon 5 polymorphisms in the O6-alkylguanine DNA alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke Cancer Epidemiol. Biomarkers Prev. 2004 13 320 323 14973087
51. Yang M. Coles B.F. Caporaso N.E. Choi Y. Lang N.P. Kadlubar F.F. Lack of association between Caucasian lung cancer risk and O6-methylguanine-DNA methyltransferase-codon 178 genetic polymorphism Lung Cancer 2004 44 281 286 15140540
52. Chae M.H. Jang J.S. Kang H.G. Park J.H. Park J.M. Lee W.K. Kam S. Lee E.B. Son J.W. Park J.Y. O6-alkylguanine-DNA alkyltransferase gene polymorphisms and the risk of primary lung cancer Mol. Carcinog. 2006 45 239 249 16385589

상세보기
53. Zhong Y. Huang Y. Zhang T. Ma C. Zhang S. Fan W. Chen H. Qian J. Lu D. Effects of O6-methylguanine-DNA methyltransferase (MGMT) polymorphisms on cancer: a meta-analysis Mutagenesis 2010 25 83 95 19892775

상세보기
54. Wang L. Liu H. Zhang Z. Spitz M.R. Wei Q. Association of genetic variants of O6-methylguanine-DNA methyltransferase with risk of lung cancer in non-Hispanic Whites Cancer Epidemiol. Biomarkers Prev. 2006 15 2364 2369 17164358
55. Hung R.J. Christiani D.C. Risch A. Popanda O. Haugen A. Zienolddiny S. Benhamou S. Bouchardy C. Lan Q. Spitz M.R. International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways Cancer Epidemiol. Biomarkers Prev. 2008 17 3081 3089 18990748
56. Riely G.J. Kris M.G. Rosenbaum D. Marks J. Li A. Chitale D.A. Nafa K. Riedel E.R. Hsu M. Pao W. Miller V.A. Ladanyi M. Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma Clin. Cancer Res. 2008 14 5731 5734 18794081

상세보기
57. Sun S. Schiller J.H. Gazdar A.F. Lung cancer in never smokers--a different disease Nat. Rev. Cancer 2007 7 778 790 17882278

상세보기
58. Slebos R.J. Kibbelaar R.E. Dalesio O. Kooistra A. Stam J. Meijer C.J. Wagenaar S.S. Vanderschueren R.G. van Zandwijk N. Mooi W.J. K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung N. Engl. J. Med. 1990 323 561 565 2199829

상세보기
59. Keohavong P. DeMichele M.A. Melacrinos A.C. Landreneau R.J. Weyant R.J. Siegfried J.M. Detection of K-ras mutations in lung carcinomas: relationship to prognosis Clin. Cancer Res. 1996 2 411 418 9816185

상세보기
60. Ahrendt S.A. Decker P.A. Alawi E.A. Zhu Yr Y.R. Sanchez-Cespedes M. Yang S.C. Haasler G.B. Kajdacsy-Balla A. Demeure M.J. Sidransky D. Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung Cancer 2001 92 1525 1530 11745231
61. Nelson H.H. Christiani D.C. Mark E.J. Wiencke J.K. Wain J.C. Kelsey K.T. Implications and prognostic value of K-ras mutation for early-stage lung cancer in women J. Natl. Cancer Inst. 1999 91 2032 2038 10580029

상세보기
62. Boldrini L. Ali G. Gisfredi S. Ursino S. Baldini E. Melfi F. Lucchi M. Comin C.E. Maddau C. Tibaldi C. Camacci T. Servadio A. Mussi A. Fontanini G. Epidermal growth factor receptor and K-RAS mutations in 411 lung adenocarcinoma: a population-based prospective study Oncol. Rep. 2009 22 683 691 19724844
63. Chiba I. Takahashi T. Nau M.M. D'Amico D. Curiel D.T. Mitsudomi T. Buchhagen D.L. Carbone D. Piantadosi S. Koga H. Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group Oncogene 1990 5 1603 1610 1979160

상세보기
64. Kure E.H. Ryberg D. Hewer A. Phillips D.H. Skaug V. Baera R. Haugen A. p53 mutations in lung tumours: relationship to gender and lung DNA adduct levels Carcinogenesis 1996 17 2201 2205 8895489

상세보기
65. Tammemagi M.C. McLaughlin J.R. Bull S.B. Meta-analyses of p53 tumor suppressor gene alterations and clinicopathological features in resected lung cancers Cancer Epidemiol. Biomarkers Prev. 1999 8 625 634 10428201
66. Toyooka S. Tsuda T. Gazdar A.F. The TP53 gene, tobacco exposure, and lung cancer Hum. Mutat. 2003 21 229 239 12619108
67. Marrogi A.J. Mechanic L.E. Welsh J.A. Bowman E.D. Khan M.A. Enewold L. Shields P.G. Harris C.C. TP53 mutation spectrum in lung cancer is not different in women and men Cancer Epidemiol. Biomarkers Prev. 2005 14 1031 1033 15824188
68. Fang S. Krahe R. Lozano G. Han Y. Chen W. Post S.M. Zhang B. Wilson C.D. Bachinski L.L. Strong L.C. Amos C.I. Effects of MDM2, MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations PLoS One 2010 5 e10813 20520810

상세보기
69. Bond G.L. Hu W. Levine A.J. MDM2 is a central node in the p53 pathway: 12 years and counting Curr. Cancer Drug Targets 2005 5 3 8 15720184

상세보기
70. Bond G.L. Hu W. Bond E.E. Robins H. Lutzker S.G. Arva N.C. Bargonetti J. Bartel F. Taubert H. Wuerl P. Onel K. Yip L. Hwang S.J. Strong L.C. Lozano G. Levine A.J. A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans Cell 2004 119 591 602 15550242

상세보기
71. Bougeard G. Baert-Desurmont S. Tournier I. Vasseur S. Martin C. Brugieres L. Chompret A. Bressac-de Paillerets B. Stoppa-Lyonnet D. Bonaiti-Pellie C. Frebourg T. Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li- Fraumeni syndrome J. Med. Genet. 2006 43 531 533 16258005

상세보기
72. Bond G.L. Hirshfield K.M. Kirchhoff T. Alexe G. Bond E.E. Robins H. Bartel F. Taubert H. Wuerl P. Hait W. Toppmeyer D. Offit K. Levine A.J. MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner Cancer Res. 2006 66 5104 5110 16707433

상세보기
73. Marchetti A. Martella C. Felicioni L. Barassi F. Salvatore S. Chella A. Camplese P.P. Iarussi T. Mucilli F. Mezzetti A. Cuccurullo F. Sacco R. Buttitta F. EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment J. Clin. Oncol. 2005 23 857 865 15681531
74. Hsieh R.K. Lim K.H. Kuo H.T. Tzen C.Y. Huang M.J. Female sex and bronchioloalveolar pathologic subtype predict EGFR mutations in non-small cell lung cancer Chest 2005 128 317 321 16002952

상세보기
75. Shigematsu H. Lin L. Takahashi T. Nomura M. Suzuki M. Wistuba II Fong K.M. Lee H. Toyooka S. Shimizu N. Fujisawa T. Feng Z. Roth J.A. Herz J. Minna J.D. Gazdar A.F. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers J. Natl. Cancer Inst. 2005 97 339 346 15741570

상세보기
76. Bell D.W. Lynch T.J. Haserlat S.M. Harris P.L. Okimoto R.A. Brannigan B.W. Sgroi D.C. Muir B. Riemenschneider M.J. Iacona R.B. Krebs A.D. Johnson D.H. Giaccone G. Herbst R.S. Manegold C. Fukuoka M. Kris M.G. Baselga J. Ochs J.S. Haber D.A. Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials J. Clin. Oncol. 2005 23 8081 8092 16204011

상세보기
77. Sasaki H. Shimizu S. Endo K. Takada M. Kawahara M. Tanaka H. Matsumura A. Iuchi K. Haneda H. Suzuki E. Kobayashi Y. Yano M. Fujii Y. EGFR and erbB2 mutation status in Japanese lung cancer patients Int. J. Cancer 2006 118 180 184 16003726

상세보기
78. Sasaki H. Okuda K. Kawano O. Endo K. Yukiue H. Yokoyama T. Yano M. Fujii Y. ErbB4 expression and mutation in Japanese patients with lung cancer Clin. Lung Cancer 2007 8 429 433 17681096

상세보기
79. Matsuo K. Ito H. Yatabe Y. Hiraki A. Hirose K. Wakai K. Kosaka T. Suzuki T. Tajima K. Mitsudomi T. Risk factors differ for non-small-cell lung cancers with and without EGFR mutation: assessment of smoking and sex by a case-control study in Japanese Cancer Sci. 2007 98 96 101 17054433

상세보기
80. Rosell R. Moran T. Queralt C. Porta R. Cardenal F. Camps C. Majem M. Lopez-Vivanco G. Isla D. Provencio M. Insa A. Massuti B. Gonzalez-Larriba J.L. Paz-Ares L. Bover I. Garcia-Campelo R. Moreno M.A. Catot S. Rolfo C. Reguart N. Palmero R. Sanchez J.M. Bastus R. Mayo C. Bertran-Alamillo J. Molina M.A. Sanchez J.J. Taron M. Screening for epidermal growth factor receptor mutations in lung cancer N. Engl. J. Med. 2009 361 958 967 19692684

상세보기
81. McMillen E. Ye F. Li G. Wu Y. Yin G. Liu W. Epidermal growth factor receptor (EGFR) mutation and p-EGFR expression in resected non-small cell lung cancer Exp. Lung Res. 2010 36 531 537 20939760

상세보기
82. Toyooka S. Matsuo K. Shigematsu H. Kosaka T. Tokumo M. Yatabe Y. Ichihara S. Inukai M. Suehisa H. Soh J. Kiura K. Fong K.M. Lee H. Wistuba II Gazdar A.F. Mitsudomi T. Date H. The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer Clin. Cancer Res. 2007 13 5763 5768 17908966

상세보기
83. Tanaka T. Matsuoka M. Sutani A. Gemma A. Maemondo M. Inoue A. Okinaga S. Nagashima M. Oizumi S. Uematsu K. Nagai Y. Moriyama G. Miyazawa H. Ikebuchi K. Morita S. Kobayashi K. Hagiwara K. Frequency of and variables associated with the EGFR mutation and its subtypes Int. J. Cancer 2010 126 651 655 19609951

상세보기
84. Zhu C.Q. da Cunha Santos G. Ding K. Sakurada A. Cutz J.C. Liu N. Zhang T. Marrano P. Whitehead M. Squire J.A. Kamel-Reid S. Seymour L. Shepherd F.A. Tsao M.S. Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21 J. Clin. Oncol. 2008 26 4268 4275 18626007

상세보기
85. Hirsch F.R. Varella-Garcia M. Bunn P.A. Jr. Di Maria M.V. Veve R. Bremmes R.M. Baron A.E. Zeng C. Franklin W.A. Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis J. Clin. Oncol. 2003 21 3798 3807 12953099

상세보기
86. Hirsch F.R. Varella-Garcia M. Bunn P.A. Jr. Franklin W.A. Dziadziuszko R. Thatcher N. Chang A. Parikh P. Pereira J.R. Ciuleanu T. von Pawel J. Watkins C. Flannery A. Ellison G. Donald E. Knight L. Parums D. Botwood N. Holloway B. Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer J. Clin. Oncol. 2006 24 5034 5042 17075123

상세보기
87. Jeon Y.K. Sung S.W. Chung J.H. Park W.S. Seo J.W. Kim C.W. Chung D.H. Clinicopathologic features and prognostic implications of epidermal growth factor receptor (EGFR) gene copy number and protein expression in non-small cell lung cancer Lung Cancer 2006 54 387 398 17011067
88. Sasaki H. Shimizu S. Okuda K. Kawano O. Yukiue H. Yano M. Fujii Y. Epidermal growth factor receptor gene amplification in surgical resected Japanese lung cancer Lung Cancer 2009 64 295 300 19058870
89. Jou Y.S. Lo Y.L. Hsiao C.F. Chang G.C. Tsai Y.H. Su W.C. Chen Y.M. Huang M.S. Chen H.L. Chen C.J. Yang P.C. Hsiung C.A. Association of an EGFR intron 1 SNP with never-smoking female lung adenocarcinoma patients Lung Cancer 2009 64 251 256 19026460

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더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
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