[논문]An Association Study of Polymorphisms in JAK3 Gene with Lung Cancer in the Korean Population

Yoo, Wonbeak; Jung, Hae-Yun; Lim, Seungjoon; Sung, Jae Sook; Park, Kyong Hwa; Ryu, Jeong Seon; Shin, Sang Won; Kim, Jun Suk; Seo, Jae Hong; Kim, Yeul Hong

doi:10.4143/crt.2011.43.2.108

[국내논문] An Association Study of Polymorphisms in JAK3 Gene with Lung Cancer in the Korean Population 원문보기

Cancer research and treatment : official journal of Korean Cancer Association, v.43 no.2, 2011년, pp.108 - 116

Yoo, Wonbeak (Brain Korea 21 Project for Biomedical Science, Seoul, Korea.) , Jung, Hae-Yun (Brain Korea 21 Project for Biomedical Science, Seoul, Korea.) , Lim, Seungjoon (Brain Korea 21 Project for Biomedical Science, Seoul, Korea.) , Sung, Jae Sook (Brain Korea 21 Project for Biomedical Science, Seoul, Korea.) , Park, Kyong Hwa (Division of Oncology) , Ryu, Jeong Seon (Department of Internal Medicine, Inha University College of Medicine, Incheon, Korea.) , Shin, Sang Won (Division of Oncology) , Kim, Jun Suk (Brain Korea 21 Project for Biomedical Science, Seoul, Korea.) , Seo, Jae Hong (Division of Oncology) , Kim, Yeul Hong (Brain Korea 21 Project for Biomedical Science, Seoul, Korea.)

Abstract ▼ AI-Helper

PurposeThe genetic alteration of the janus kinases (JAKs), non-receptor tyrosine kinase, is related to the development of human cancers. However, little is known about how the sequence variation of JAK3 contributes to the development of lung cancer. This study investigated whether polymorphisms at the promoter region of the JAK3 gene are associated with the risk of lung cancer in the Korean population.Materials and MethodsA total of 819 subjects, including 409 lung cancer patients and 410 healthy controls were recruited. The SNaPshot assay and polymerase chain reaction-restriction fragment length polymorphism analysis were used, and logistic regression analyses were performed to characterize the association between polymorphisms of JAK3 and lung cancer risk.ResultsThree polymorphisms (-672 G>A, +64 A>G and +227 G>A) of JAK3 were analyzed for large-scale genotyping (n=819). Statistical analyses revealed that polymorphisms and haplotypes in the JAK3 gene were not significantly associated with lung cancer.ConclusionJAK3 gene was not significantly associated with the risk of lung cancer in the Korean population.

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