[논문]Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial

Jedel, Elizabeth; Labrie, Fernand; Odé; n, Anders; Holm, Gö; ran; Nilsson, Lars; Janson, Per Olof; Lind, Anna-Karin; Ohlsson, Claes; Stener-Victorin, Elisabet

doi:10.1152/ajpendo.00495.2010

Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial

American journal of physiology, Endocrinology and metabolism, v.300 no.1, 2011년, pp.E37 - E45

Jedel, Elizabeth (Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden) , Labrie, Fernand , Odén, Anders (Laval University Research Center in Molecular Endocrinology, Oncology and Human Genomics, CHUL Research Center, Quebec, Canada) , Holm, Göran , Nilsson, Lars (Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg) , Janson, Per Olof , Lind, Anna-Karin (Institute of Medicine, Department of Metabolism and Cardiovascular Disease,) , Ohlsson, Claes (Institute of Clinical Science, Department of Obstetrics and Gynecology,) , Stener-Victorin, Elisabet (Institute of Clinical Science, Department of Obstetrics and Gynecology,)

Abstract ▼ AI-Helper

Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, is characterized by hyperandrogenism, oligo/amenorrhea, and polycystic ovaries. We aimed to determine whether low-frequency electro-acupuncture (EA) would decrease hyperandrogenism and improve oligo/amenorrhea more effectively than physical exercise or no intervention. We randomized 84 women with PCOS, aged 18-37 yr, to 16 wk of low-frequency EA, physical exercise, or no intervention. The primary outcome measure changes in the concentration of total testosterone (T) at week 16 determined by gas and liquid chromatography-mass spectrometry was analyzed by intention to treat. Secondary outcome measures were changes in menstrual frequency; concentrations of androgens, estrogens, androgen precursors, and glucuronidated androgen metabolites; and acne and hirsutism. Outcomes were assessed at baseline, after 16 wk of intervention, and after a 16-wk follow-up. After 16 wk of intervention, circulating T decreased by −25%, androsterone glucuronide by −30%, and androstane-3α,17β-diol-3-glucuronide by −28% in the EA group ( P = 0.038, 0.030, and 0.047, respectively vs. exercise); menstrual frequency increased to 0.69/month from 0.28 at baseline in the EA group ( P = 0.018 vs. exercise). After the 16-wk follow-up, the acne score decreased by −32% in the EA group ( P = 0.006 vs. exercise). Both EA and exercise improved menstrual frequency and decreased the levels of several sex steroids at week 16 and at the 16-wk follow-up compared with no intervention. Low-frequency EA and physical exercise improved hyperandrogenism and menstrual frequency more effectively than no intervention in women with PCOS. Low-frequency EA was superior to physical exercise and may be useful for treating hyperandrogenism and oligo/amenorrhea.

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Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial

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