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Cell, v.146 no.5, 2011년, pp.682 - 695
Rubinsztein, David C. (Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0XY, UK) , Mariño, Guillermo (INSERM, U848, 39 rue Calmette Desmoulins, 94805 Villejuif, France) , Kroemer, Guido (INSERM, U848, 39 rue Calmette Desmoulins, 94805 Villejuif, France)
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Genetic inhibition of autophagy induces degenerative changes in mammalian tissues that resemble those associated with aging, and normal and pathological aging are often associated with a reduced autophagic potential. Pharmacological or genetic manipulations that increase life span in model organisms...
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