다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Biochemical pharmacology, v.82 no.9, 2011년, pp.1163 - 1174
Chiaravalli, Jeanne (Institut Pasteur, Unité) , Fontan, Elisabeth (de Biochimie Structurale et Cellulaire, CNRS, URA 2185, France) , Fsihi, Hafida (Institut Pasteur, Unité) , Coic, Yves-Marie (de Biochimie Structurale et Cellulaire, CNRS, URA 2185, France) , Baleux, Françoise (Institut Pasteur, Unité) , Véron, Michel (de Biochimie Structurale et Cellulaire, CNRS, URA 2185, France) , Agou, Fabrice (Institut Pasteur, Unité)
AI-Helper
Graphical abstract AbstractAberrant and constitutive NF-κB activation are frequently reported in numerous tumor types, making its inhibition an attractive target for the treatment of certain cancers. NEMO (NF-κB essential modulator) is the crucial component of the canonical NF-κB p...
Cell Hayden 132 344 2008 10.1016/j.cell.2008.01.020 Shared principles in NF-kappaB signaling
Nat Rev Mol Cell Biol Perkins 8 49 2007 10.1038/nrm2083 Integrating cell-signalling pathways with NF-kappaB and IKK function
Oncogene Scheidereit 25 6685 2006 10.1038/sj.onc.1209934 IkappaB kinase complexes: gateways to NF-kappaB activation and transcription
Annu Rev Immunol Vallabhapurapu 27 693 2009 10.1146/annurev.immunol.021908.132641 Regulation and function of NF-kappaB transcription factors in the immune system
Nat Immunol Sato 6 1087 2005 10.1038/ni1255 Essential function for the kinase TAK1 in innate and adaptive immune responses
Genes Dev Shim 19 2668 2005 10.1101/gad.1360605 TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
Nat Struct Mol Biol Kulathu 16 1328 2009 10.1038/nsmb.1731 Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain
EMBO J Sato 28 2461 2009 10.1038/emboj.2009.160 Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80
Nat Cell Biol Tokunaga 11 123 2009 10.1038/ncb1821 Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
Nature Gerlach 471 591 2011 10.1038/nature09816 Linear ubiquitination prevents inflammation and regulates immune signalling
Nature Ikeda 471 637 2011 10.1038/nature09814 SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis
Nature Tokunaga 471 633 2011 10.1038/nature09815 SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex
Mol Cell Haas 36 831 2009 10.1016/j.molcel.2009.10.013 Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
Mol Cell Xu 36 302 2009 10.1016/j.molcel.2009.10.002 A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta
Nature Xia 461 114 2009 10.1038/nature08247 Direct activation of protein kinases by unanchored polyubiquitin chains
Mol Cell Biol Marienfeld 26 9209 2006 10.1128/MCB.00478-06 Dimerization of the I kappa B kinase-binding domain of NEMO is required for tumor necrosis factor alpha-induced NF-kappa B activity
Structure Rushe 16 798 2008 10.1016/j.str.2008.02.012 Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
Mol Cell Bagneris 30 620 2008 10.1016/j.molcel.2008.04.029 Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome
J Mol Biol Grubisha 395 89 2010 10.1016/j.jmb.2009.10.018 DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding
J Biol Chem Agou 279 54248 2004 10.1074/jbc.M406423200 Inhibition of NF-kappa B activation by peptides targeting NF-kappa B essential modulator (nemo) oligomerization
FEBS Lett Heyninck 536 135 2003 10.1016/S0014-5793(03)00041-3 Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1
Trends Cell Biol Sebban 16 569 2006 10.1016/j.tcb.2006.09.004 Posttranslational modifications of NEMO and its partners in NF-kappaB signaling
Oncogene Wagner 27 3739 2008 10.1038/sj.onc.1211042 Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins
Mol Cell Ea 22 245 2006 10.1016/j.molcel.2006.03.026 Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
Nat Cell Biol Wu 8 398 2006 10.1038/ncb1384 Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation
Mol Cell Lo 33 602 2009 10.1016/j.molcel.2009.01.012 Structural basis for recognition of diubiquitins by NEMO
Cell Rahighi 136 1098 2009 10.1016/j.cell.2009.03.007 Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
FEBS Lett Yoshikawa 583 3317 2009 10.1016/j.febslet.2009.09.028 Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin
J Mol Biol Cordier 377 1419 2008 10.1016/j.jmb.2008.01.048 Solution structure of NEMO zinc-finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation
J Biol Chem Cordier 284 2902 2009 10.1074/jbc.M806655200 The zinc finger of NEMO is a functional ubiquitin-binding domain
EMBO J Laplantine 28 2885 2009 10.1038/emboj.2009.241 NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain
Nat Rev Drug Discov Baud 8 33 2009 10.1038/nrd2781 Is, NF-kappaB a good target for cancer therapy? Hopes and pitfalls
Nat Rev Immunol Karin 5 749 2005 10.1038/nri1703 NF-kappaB: linking inflammation and immunity to cancer development and progression
Cell Death Differ Kim 13 738 2006 10.1038/sj.cdd.4401877 IKK as therapeutic targets in cancer
Cell Death Differ Legarda-Addison 16 1279 2009 10.1038/cdd.2009.41 NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling
Blood Nagashima 107 4266 2006 10.1182/blood-2005-09-3852 Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKbeta
Nat Genet Doffinger 27 277 2001 10.1038/85837 X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling
Proc Natl Acad Sci USA Bloor 105 1279 2008 10.1073/pnas.0706552105 Signal processing by its coil zipper domain activates IKK gamma
Oncogene Harhaj 19 1448 2000 10.1038/sj.onc.1203445 Somatic mutagenesis studies of NF-kappa B signaling in human T cells: evidence for an essential role of IKK gamma in NF-kappa B activation by T-cell costimulatory signals and HTLV-I Tax protein
FEBS J Fontan 274 2540 2007 10.1111/j.1742-4658.2007.05788.x NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex
Biochemistry Mousson 41 13611 2002 10.1021/bi026274b Deciphering the role of individual acyl chains in the interaction network between phosphatidylserines and a single-spanning membrane protein
Mol Cell Biol Courtois 17 1441 1997 10.1128/MCB.17.3.1441 Characterization of a mutant cell line that does not activate NF-kappaB in response to multiple stimuli
J Biol Chem Agou 279 27861 2004 10.1074/jbc.M314278200 The trimerization domain of NEMO is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains
Protein Sci Wyler 16 2013 2007 10.1110/ps.072924907 Inhibition of NF-kappaB activation with designed ankyrin-repeat proteins targeting the ubiquitin-binding/oligomerization domain of NEMO
Br J Pharmacol Jones 145 1093 2005 10.1038/sj.bjp.0706279 Characterisation of cell-penetrating peptide-mediated peptide delivery
Adv Drug Deliv Rev Wadia 57 579 2005 10.1016/j.addr.2004.10.005 Transmembrane delivery of protein and peptide drugs by TAT-mediated transduction in the treatment of cancer
Nat Rev Mol Cell Biol Sharrocks 2 827 2001 10.1038/35099076 The ETS-domain transcription factor family
Oncogene Mechta-Grigoriou 20 2378 2001 10.1038/sj.onc.1204381 The mammalian Jun proteins: redundancy and specificity
Cell Crabtree 109 Suppl. S67 2002 10.1016/S0092-8674(02)00699-2 NFAT signaling: choreographing the social lives of cells
Cell Death Differ Papa 13 712 2006 10.1038/sj.cdd.4401865 The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease
Expert Opin Drug Deliv Bidwell 6 1033 2009 10.1517/17425240903143745 Therapeutic peptides for cancer therapy. Part I - peptide inhibitors of signal transduction cascades
Nature Moellering 462 182 2009 10.1038/nature08543 Direct inhibition of the NOTCH transcription factor complex
Curr Opin Genet Dev Prive 16 71 2006 10.1016/j.gde.2005.12.010 Specific peptides for the therapeutic targeting of oncogenes
Expert Opin Drug Deliv Raucher 6 1049 2009 10.1517/17425240903158909 Therapeutic peptides for cancer therapy. Part II - cell cycle inhibitory peptides and apoptosis-inducing peptides
EMBO J Sato 28 3903 2009 10.1038/emboj.2009.345 Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3
Biochemistry Acharya 45 11324 2006 10.1021/bi060822u Stability of 100 homo and heterotypic coiled-coil a-a’ pairs for ten amino acids (A, L, I, V, N, K, S, T, E, and R)
Curr Opin Struct Biol Grigoryan 18 477 2008 10.1016/j.sbi.2008.04.008 Structural specificity in coiled-coil interactions
Proc Natl Acad Sci USA Kammerer 95 13419 1998 10.1073/pnas.95.23.13419 An autonomous folding unit mediates the assembly of two-stranded coiled coils
J Mol Biol Myers 289 205 1999 10.1006/jmbi.1999.2747 Reinterpretation of GCN4-p1 folding kinetics: partial helix formation precedes dimerization in coiled coil folding
Proc Natl Acad Sci USA Steinmetz 104 7062 2007 10.1073/pnas.0700321104 Molecular basis of coiled-coil formation
Mol Cell Bertrand 30 689 2008 10.1016/j.molcel.2008.05.014 cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
J Biol Chem Varfolomeev 283 24295 2008 10.1074/jbc.C800128200 c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation
Cell Deng 103 351 2000 10.1016/S0092-8674(00)00126-4 Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
Biochemistry Yin 48 10558 2009 10.1021/bi901462e Structural basis for the lack of E2 interaction in the RING domain of TRAF2
Nat Struct Mol Biol Yin 16 658 2009 10.1038/nsmb.1605 E2 interaction and dimerization in the crystal structure of TRAF6
FEBS Lett Park 566 151 2004 10.1016/j.febslet.2004.04.021 Receptor interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c-IAP1 and c-IAP2) in vitro
Science May 289 1550 2000 10.1126/science.289.5484.1550 Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.