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The effect of TNFα secreted from macrophages activated by titanium particles on osteogenic activity regulated by WNT/BMP signaling in osteoprogenitor cells

Biomaterials, v.33 no.17, 2012년, pp.4251 - 4263  

Lee, Sang-Soo (Infectious Disease Medical Research Center & Department of Pharmacology, College of Medicine, Hallym University, Chucheon, Gangwon-do 200-702, Republic of Korea) ,  Sharma, Ashish R. (Infectious Disease Medical Research Center & Department of Pharmacology, College of Medicine, Hallym University, Chucheon, Gangwon-do 200-702, Republic of Korea) ,  Choi, Byung-Soo (Infectious Disease Medical Research Center & Department of Pharmacology, College of Medicine, Hallym University, Chucheon, Gangwon-do 200-702, Republic of Korea) ,  Jung, Jun-Sub (Infectious Disease Medical Research Center & Department of Pharmacology, College of Medicine, Hallym University, Chucheon, Gangwon-do 200-702, Republic of Korea) ,  Chang, Jun-Dong (Institute for Skeletal Aging & Orthopaedic Surgery, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chucheon, Republic of Korea) ,  Park, Seonghun (Institute for Skeletal Aging & Orthopaedic Surgery, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chucheon, Republic of Korea) ,  Salvati, Eduardo A. (Orthopedic Surgery & Osteolysis Resear) ,  Purdue, Edward P. ,  Song, Dong-Keun ,  Nam, Ju-Suk

Abstract AI-Helper 아이콘AI-Helper

AbstractWear particles are the major cause of osteolysis associated with failure of implant following total joint replacement. During this pathologic process, activated macrophages mediate inflammatory responses to increase osteoclastogenesis, leading to enhanced bone resorption. In osteolysis cause...

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