최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기Mass spectrometry reviews, v.32 no.6, 2013년, pp.453 - 465
Vandermarliere, Elien (Department of Medical Protein Research, VIB, B‐) , Mueller, Michael (9000 Ghent, Belgium) , Martens, Lennart (EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK)
AbstractNowadays, mass spectrometry‐based proteomics is carried out primarily in a bottom‐up fashion, with peptides obtained after proteolytic digest of a whole proteome lysate as the primary analytes instead of the proteins themselves. This experimental setup crucially relies on a prote...
Abita JP , Delaage M , Lazdunski M . 1969 . The mechanism of activation of trypsinogen. The role of the four N‐terminal aspartyl residues . Eur J Biochem 8 : 314 – 324 .
Alvarez‐Llamas G , de la Cuesta F , Barderas MEG , Darde V , Padial LR , Vivanco F . 2008 . Recent advances in atherosclerosis‐based proteomics: New biomarkers and a future perspective . Expert Rev Proteomics 5 : 679 – 691 .
Anderson NL , Anderson NG , Pearson TW , Borchers CH , Paulovich AG , Patterson SD , Gillette M , Aebersold R , Carr SA . 2009 . A human proteome detection and quantitation project . Mol Cell Proteomics 8 : 883 – 886 .
Banumathi E , Haribalaganesh R , Babu SSP , Kumar NS , Sangiliyandi G . 2009 . High‐yielding enzymatic method for isolation and culture of microvascular endothelial cells from bovine retinal blood vessels . Microvasc Res 77 : 377 – 381 .
Berg J , Tymoczko J , Stryer L . 2002 . Biochemistry , 5th edition . New York : WH Freeman and Company .
Blow DM , Birktoft JJ , Hartley BS . 1969 . Role of a buried acid group in the mechanism of action of chymotrypsin . Nature 221 : 337 – 340 .
Bode W , Schwager P . 1975 . The refined crystal structure of bovine beta‐trypsin at 1.8 a resolution. II. Crystallographic refinement, calcium binding site, benzamidine binding site and active site at PH 7.0 . J Mol Biol 98 : 693 – 717 .
Bode W , Fehlhammer H , Huber R . 1976 . Crystal structure of bovine trypsinogen at 1–8 a resolution. I. Data collection, application of Patterson search techniques and preliminary structural interpretation . J Mol Biol 106 : 325 – 335 .
Braconi D , Amato L , Bernardini G , Arena S , Orlandini M , Scaloni A , Santucci A . 2011 . Surfome analysis of a wild‐type wine Saccharomyces cerevisiae strain . Food Microbiol 28 : 1220 – 1230 .
Burkhart JM , Schumbrutzki C , Wortelkamp S , Sickmann A , Zahedi RP . 2012 . Systematic and quantitative comparison of digest efficiency and specificity reveals the impact of trypsin quality on MS‐based proteomics . J Proteomics 75 : 1454 – 1462 .
Chen EI , Cociorva D , Norris JL , Yates JR III. 2007 . Optimization of mass spectrometry‐compatible surfactants for shotgun proteomics . J Proteome Res 6 : 2529 – 2538 .
Clark S , Eckardt G , Siddle K , Harrison LC . 1991 . Changes in insulin‐receptor structure associated with trypsin‐induced activation of the receptor tyrosine kinase . Biochem J 276 ( Pt 1 ): 27 – 33 .
Conrads TP , Anderson GA , Veenstra TD , Pasa‐Tolić L , Smith RD . 2000 . Utility of accurate mass tags for proteome‐wide protein identification . Anal Chem 72 : 3349 – 3354 .
Craig R , Beavis RC . 2004 . Tandem: Matching proteins with tandem mass spectra . Bioinformatics 20 : 1466 – 1467 .
Déry O , Corvera CU , Steinhoff M , Bunnett NW . 1998 . Proteinase‐activated receptors: Novel mechanisms of signaling by serine proteases . Am J Physiol 274 : C1429 – C1452 .
Desiderio DM , Kai M . 1983 . Preparation of stable isotope‐incorporated peptide internal standards for field desorption mass spectrometry quantification of peptides in biologic tissue . Biomed Mass Spectrom 10 : 471 – 479 .
Di Cera E . 2009 . Serine proteases . IUBMB Life 61 : 510 – 515 .
Dreisbach A , van der Kooi‐Pol MM , Otto A , Gronau K , Bonarius HPJ , Westra H , Groen H , Becher D , Hecker M , van Dijl JM . 2011 . Surface shaving as a versatile tool to profile global interactions between human serum proteins and the staphylococcus aureus cell surface . Proteomics 11 : 2921 – 2930 .
Duan C , Huo G , Yang L , Ren D , Chen J . 2012 . Comparison of sensitization between beta‐lactoglobulin and its hydrolysates . Asian Pac J Allergy Immunol 30 : 32 – 39 .
Ehn B , Allmere T , Telemo E , Bengtsson U , Ekstrand B . 2005 . Modification of IGE binding to beta‐lactoglobulin by fermentation and proteolysis of cow's milk . J Agric Food Chem 53 : 3743 – 3748 .
Ekici OD , Paetzel M , Dalbey RE . 2008 . Unconventional serine proteases: Variations on the catalytic Ser/His/Asp triad configuration . Protein Sci 17 : 2023 – 2037 .
Fehlhammer H , Bode W , Huber R . 1977 . Crystal structure of bovine trypsinogen at 1–8 a resolution. II. Crystallographic refinement, refined crystal structure and comparison with bovine trypsin . J Mol Biol 111 : 415 – 438 .
Feng J , Naiman DQ , Cooper B . 2007 . Probability‐based pattern recognition and statistical framework for randomization: Modeling tandem mass spectrum/peptide sequence false match frequencies . Bioinformatics 23 : 2210 – 2217 .
Fischer F , Poetsch A . 2006 . Protein cleavage strategies for an improved analysis of the membrane proteome . Proteome Sci 4 : 2 .
Fonslow BR , Stein BD , Webb KJ , Xu T , Choi J , Park SK , Yates JR III. 2013 . Digestion and depletion of abundant proteins improves proteomic coverage . Nat Methods 10 : 54 – 56 .
Fontana A , Polverino de Laureto P , De Filippis V , Scaramella E , Zambonin M . 1997 . Probing the partly folded states of proteins by limited proteolysis . Fold Des 2 : R17 – R26 .
Freer ST , Kraut J , Robertus JD , Wright HT , Xuong NH . 1970 . Chymotrypsinogen: 2.5‐Angstrom crystal structure, comparison with alpha‐chymotrypsin, and implications for zymogen activation . Biochemistry 9 : 1997 – 2009 .
Frewen B , MacCoss MJ . 2007 . Using bibliospec for creating and searching tandem ms peptide libraries . Curr Protoc Bioinformatics Chapter 13 : Unit 13.7 .
Geer LY , Markey SP , Kowalak JA , Wagner L , Xu M , Maynard DM , Yang X , Shi W , Bryant SH . 2004 . Open mass spectrometry search algorithm . J Proteome Res 3 : 958 – 964 .
Gevaert K , Van Damme P , Ghesquière B , Impens F , Martens L , Helsens K , Vandekerckhove J . 2007 . A la carte proteomics with an emphasis on gel‐free techniques . Proteomics 7 : 2698 – 2718 .
Glatter T , Ludwig C , Ahrne E , Aebersold R , Heck AJR , Schmidt A . 2012 . Large‐scale quantitative assessment of different in‐solution protein digestion protocols reveals superior cleavage efficiency of tandem Lys‐C/trypsin proteolysis over trypsin digestion . J Proteome Res 11 : 5145 – 5156 .
Gordon JA , Jencks WP . 1963 . The relationship of structure to the effectiveness of denaturing agents for proteins . Biochemistry 2 : 47 – 57 .
Grabe M , Forsberg B . 1986 . Retrograde trypsin instillation into the renal pelvis for the dissolution of obstructive blood clots . Eur Urol 12 : 69 – 70 .
Greene RFJ , Pace CN . 1974 . Urea and guanidine hydrochloride denaturation of ribonuclease, lysozyme, alpha‐chymotrypsin, and beta‐lactoglobulin . J Biol Chem 249 : 5388 – 5393 .
Halfon S , Craik CS . 1998 . Trypsin . In: Barrett AJ , Rawlings ND , Woessner JF , editors. Handbook of proteolytic enzymes . London : Academic Press . pp. 12 – 21 .
Hamady M , Cheung THT , Tufo H , Knight R . 2005 . Does protein structure influence trypsin miscleavage? Using structural properties to predict the behavior of related proteins . IEEE Eng Med Biol Mag 24 : 58 – 66 .
Hancock W , Omenn G , Legrain P , Paik Y . 2011 . Proteomics, human proteome project, and chromosomes . J Proteome Res 10 : 210 .
Harris WA , Janecki DJ , Reilly JP . 2002 . Use of matrix clusters and trypsin autolysis fragments as mass calibrants in matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry . Rapid Commun Mass Spectrom 16 : 1714 – 1722 .
Hedstrom L . 2002 . Serine protease mechanism and specificity . Chem Rev 102 : 4501 – 4524 .
Hentzer B , Kobayasi T . 1975 . Separation of human epidermal cells from fibroblasts in primary skin culture . Arch Dermatol Forsch 252 : 39 – 46 .
Hervey WJ IV , Strader MB , Hurst GB . 2007 . Comparison of digestion protocols for microgram quantities of enriched protein samples . J Proteome Res 6 : 3054 – 3061 .
Hirota M , Ohmuraya M , Baba H . 2006 . The role of trypsin, trypsin inhibitor, and trypsin receptor in the onset and aggravation of pancreatitis . J Gastroenterol 41 : 832 – 836 .
Holman SW , Sims PFG , Eyers CE . 2012 . The use of selected reaction monitoring in quantitative proteomics . Bioanalysis 4 : 1763 – 1786 .
Hubbard SJ . 1998 . The structural aspects of limited proteolysis of native proteins . Biochim Biophys Acta 1382 : 191 – 206 .
Jain E , Bairoch A , Duvaud S , Phan I , Redaschi N , Suzek BE , Martin MJ , McGarvey P , Gasteiger E . 2009 . Infrastructure for the life sciences: Design and implementation of the UniProt website . BMC Bioinformatics 10 : 136 .
Ji B , Logsdon CD . 2011 . Digesting new information about the role of trypsin in pancreatitis . Gastroenterology 141 : 1972 – 1975 .
Joys TM , Kim H . 1979 . The susceptibility to tryptic hydrolysis of peptide bonds involving epsilon‐ n ‐methyllysine . Biochim Biophys Acta 581 : 360 – 362 .
Käll L , Storey JD , MacCoss MJ , Noble WS . 2008 . Assigning significance to peptides identified by tandem mass spectrometry using decoy databases . J Proteome Res 7 : 29 – 34 .
Kattan JD , Cocco RR , Järvinen KM . 2011 . Milk and soy allergy . Pediatr Clin North Am 58 : 407 – 426 , x.
Kay J , Kassell B . 1971 . The autoactivation of trypsinogen . J Biol Chem 246 : 6661 – 6665 .
Keil B . 1992 . Specificity of proteolysis . Berlin—Heidelberg—New York : Springer‐Verlag .
Keuhne W . 1877 . Uber das trypsin (enzym des pankreas). Verhanlungen des naturhistorisch‐medicischen vereins zu Heidelberg , Vol. 1 . pp. 194 – 198 .
Kirkpatrick CJ , Melzner I , Göller T . 1985 . Comparative effects of trypsin, collagenase and mechanical harvesting on cell membrane lipids studied in monolayer‐cultured endothelial cells and a green monkey kidney cell line . Biochim Biophys Acta 846 : 120 – 126 .
Klammer AA , MacCoss MJ . 2006 . Effects of modified digestion schemes on the identification of proteins from complex mixtures . J Proteome Res 5 : 695 – 700 .
Kraut J . 1971 . The enzymes . New York and London : Academic Press . pp 165 – 183 .
Kunitz M . 1939 . Formation of trypsin from crystalline trypsinogen by means of enterokinase . J Gen Physiol 22 : 429 – 446 .
Lange V , Picotti P , Domon B , Aebersold R . 2008 . Selected reaction monitoring for quantitative proteomics: A tutorial . Mol Syst Biol 4 : 222 .
Lin Y , Zhou J , Bi D , Chen P , Wang X , Liang S . 2008 . Sodium‐deoxycholate‐assisted tryptic digestion and identification of proteolytically resistant proteins . Anal Biochem 377 : 259 – 266 .
Martens L , Hermjakob H , Jones P , Adamski M , Taylor C , States D , Gevaert K , Vandekerckhove J , Apweiler R . 2005 . Pride: The proteomics identifications database . Proteomics 5 : 3537 – 3545 .
Martens L , Vandekerckhove J , Gevaert K . 2005 . DBToolkit: Processing protein databases for peptide‐centric proteomics . Bioinformatics 21 : 3584 – 3585 .
Matallana‐Surget S , Leroy B , Wattiez R . 2010 . Shotgun proteomics: Concept, key points and data mining . Expert Rev Proteomics 7 : 5 – 7 .
Meyer HE , Stühler K . 2007 . High‐performance proteomics as a tool in biomarker discovery . Proteomics 7 (Suppl. 1): 18 – 26 .
Neurath H . 1994 . Proteolytic enzymes past and present: The second golden era. recollections, special section in honor of Max Perutz . Protein Sci 3 : 1734 – 1739 .
Nystedt S , Emilsson K , Wahlestedt C , Sundelin J . 1994 . Molecular cloning of a potential proteinase activated receptor . Proc Natl Acad Sci USA 91 : 9208 – 9212 .
Olsen JV , Ong S , Mann M . 2004 . Trypsin cleaves exclusively C‐terminal to arginine and lysine residues . Mol Cell Proteomics 3 : 608 – 614 .
Oppenheimer HL , Labouesse B , Hess GP . 1966 . Implication of an ionizing group in the control of conformation and activity of chymotrypsin . J Biol Chem 241 : 2720 – 2730 .
Paetzel M , Strynadka NC . 1999 . Common protein architecture and binding sites in proteases utilizing a Ser/Lys dyad mechanism . Protein Sci 8 : 2533 – 2536 .
Page MJ , Di Cera E . 2008 . Evolution of peptidase diversity . J Biol Chem 283 : 30010 – 30014 .
Paik Y , Jeong S , Omenn GS , Uhlen M , Hanash S , Cho SY , Lee H , Na K , Choi E , Yan F , Zhang F , Zhang Y , Snyder M , Cheng Y , Chen R , Marko‐Varga G , Deutsch EW , Kim H , Kwon J , Aebersold R , Bairoch A , Taylor AD , Kim KY , Lee E , Hochstrasser D , Legrain P , Hancock WS . 2012 . The chromosome‐centric human proteome project for cataloging proteins encoded in the genome . Nat Biotechnol 30 : 221 – 223 .
Paik Y , Omenn GS , Uhlen M , Hanash S , Marko‐Varga G , Aebersold R , Bairoch A , Yamamoto T , Legrain P , Lee H , Na K , Jeong S , He F , Binz P , Nishimura T , Keown P , Baker MS , Yoo JS , Garin J , Archakov A , Bergeron J , Salekdeh GH , Hancock WS . 2012 . Standard guidelines for the chromosome‐centric human proteome project . J Proteome Res 11 : 2005 – 2013 .
Pasa‐Tolić L , Masselon C , Barry RC , Shen Y , Smith RD . 2004 . Proteomic analyses using an accurate mass and time tag strategy . Biotechniques 37 : 621 – 624 , 626–633, 636 passim.
Perkins DN , Pappin DJ , Creasy DM , Cottrell JS . 1999 . Probability‐based protein identification by searching sequence databases using mass spectrometry data . Electrophoresis 20 : 3551 – 3567 .
Polgár L . 2005 . The catalytic triad of serine peptidases . Cell Mol Life Sci 62 : 2161 – 2172 .
Poncz L , Dearborn DG . 1983 . The resistance to tryptic hydrolysis of peptide bonds adjacent to N epsilon, N‐dimethyllysyl residues . J Biol Chem 258 : 1844 – 1850 .
Poschmann G , Sitek B , Sipos B , Hamacher M , Vonend O , Meyer HE , Stühler K . 2009 . Cell‐based proteome analysis: The first stage in the pipeline for biomarker discovery . Biochim Biophys Acta 1794 : 1309 – 1316 .
Proc JL , Kuzyk MA , Hardie DB , Yang J , Smith DS , Jackson AM , Parker CE , Borchers CH . 2010 . A quantitative study of the effects of chaotropic agents, surfactants, and solvents on the digestion efficiency of human plasma proteins by trypsin . J Proteome Res 9 : 5422 – 5437 .
Rabilloud T , Hochstrasser D , Simpson RJ . 2010 . Is a gene‐centric human proteome project the best way for proteomics to serve biology ? Proteomics 10 : 3067 – 3072 .
Raijmakers R , Neerincx P , Mohammed S , Heck AJR . 2010 . Cleavage specificities of the brother and sister proteases Lys‐C and Lys‐N . Chem Commun (Camb) 46 : 8827 – 8829 .
Rawlings ND , Barrett AJ . 1994 . Families of serine peptidases . Methods Enzymol 244 : 19 – 61 .
Rawlings ND , Barrett AJ , Bateman A . 2012 . MEROPS: The database of proteolytic enzymes, their substrates and inhibitors . Nucleic Acids Res 40 : D343 – D350 .
Reker D , Malmström L . 2012 . Bioinformatic challenges in targeted proteomics . J Proteome Res 11 : 4393 – 4402 .
Rice RH , Means GE , Brown WD . 1977 . Stabilization of bovine trypsin by reductive methylation . Biochim Biophys Acta 492 : 316 – 321 .
Rodriguez J , Gupta N , Smith RD , Pevzner PA . 2008 . Does trypsin cut before proline ? J Proteome Res 7 : 300 – 305 .
Rokhlin OW , Guseva NV , Taghiyev AF , Glover RA , Cohen MB . 2004 . Multiple effects of N‐alpha‐tosyl‐L‐phenylalanyl chloromethyl ketone (TPCK) on apoptotic pathways in human prostatic carcinoma cell lines . Cancer Biol Ther 3 : 761 – 768 .
Rühlmann A , Kukla D , Schwager P , Bartels K , Huber R . 1973 . Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. Crystal structure determination and stereochemistry of the contact region . J Mol Biol 77 : 417 – 436 .
Sadygov RG , Cociorva D , Yates JR III. 2004 . Large‐scale database searching using tandem mass spectra: Looking up the answer in the back of the book . Nat Methods 1 : 195 – 202 .
Schechter I , Berger A . 1967 . On the size of the active site in proteases. I. Papain . Biochem Biophys Res Commun 27 : 157 – 162 .
Schlosser A , Vanselow JT , Kramer A . 2005 . Mapping of phosphorylation sites by a multi‐protease approach with specific phosphopeptide enrichment and NanoLC‐Ms/Ms analysis . Anal Chem 77 : 5243 – 5250 .
Sha H , Ma Q , Jha RK . 2009 . Trypsin is the culprit of multiple organ injury with severe acute pancreatitis . Med Hypotheses 72 : 180 – 182 .
Shotton DM , Watson HC . 1970 . Three‐dimensional structure of tosyl‐elastase . Nature 225 : 811 – 816 .
Siepen JA , Keevil E , Knight D , Hubbard SJ . 2007 . Prediction of missed cleavage sites in tryptic peptides aids protein identification in proteomics . J Proteome Res 6 : 399 – 408 .
Smillie LB , Neurath H . 1959 . Reversible inactivation of trypsin by anhydrous formic acid . J Biol Chem 234 : 355 – 359 .
Smith RD , Anderson GA , Lipton MS , Pasa‐Tolic L , Shen Y , Conrads TP , Veenstra TD , Udseth HR . 2002 . An accurate mass tag strategy for quantitative and high‐throughput proteome measurements . Proteomics 2 : 513 – 523 .
Soleimani M , Nadri S . 2009 . A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow . Nat Protoc 4 : 102 – 106 .
Sprang S , Standing T , Fletterick RJ , Stroud RM , Finer‐Moore J , Xuong NH , Hamlin R , Rutter WJ , Craik CS . 1987 . The three‐dimensional structure of Asn102 mutant of trypsin: Role of Asp102 in serine protease catalysis . Science 237 : 905 – 909 .
Staes A , Demol H , Van Damme J , Martens L , Vandekerckhove J , Gevaert K . 2004 . Global differential non‐gel proteomics by quantitative and stable labeling of tryptic peptides with oxygen‐18 . J Proteome Res 3 : 786 – 791 .
Steinhoff M , Vergnolle N , Young SH , Tognetto M , Amadesi S , Ennes HS , Trevisani M , Hollenberg MD , Wallace JL , Caughey GH , Mitchell SE , Williams LM , Geppetti P , Mayer EA , Bunnett NW . 2000 . Agonists of proteinase‐activated receptor 2 induce inflammation by a neurogenic mechanism . Nat Med 6 : 151 – 158 .
Swaney DL , Wenger CD , Coon JJ . 2010 . Value of using multiple proteases for large‐scale mass spectrometry‐based proteomics . J Proteome Res 9 : 1323 – 1329 .
Tabb DL , Huang Y , Wysocki VH , Yates JR III. 2004 . Influence of basic residue content on fragment ion peak intensities in low‐energy collision‐induced dissociation spectra of peptides . Anal Chem 76 : 1243 – 1248 .
Thiede B , Lamer S , Mattow J , Siejak F , Dimmler C , Rudel T , Jungblut PR . 2000 . Analysis of missed cleavage sites, tryptophan oxidation and N‐terminal pyroglutamylation after in‐gel tryptic digestion . Rapid Commun Mass Spectrom 14 : 496 – 502 .
Tjalsma H , Lambooy L , Hermans PW , Swinkels DW . 2008 . Shedding & shaving: Disclosure of proteomic expressions on a bacterial face . Proteomics 8 : 1415 – 1428 .
Tobita T , Folk JE . 1967 . Chymotrypsin c. 3. Sequence of amino acids around an essential histidine residue . Biochim Biophys Acta 147 : 15 – 25 .
Tsai C , Polverino de Laureto P , Fontana A , Nussinov R . 2002 . Comparison of protein fragments identified by limited proteolysis and by computational cutting of proteins . Protein Sci 11 : 1753 – 1770 .
Uniprot Consortium . 2011 . Ongoing and future developments at the universal protein resource . Nucleic Acids Res 39 : D214 – D219 .
Vaudel M , Sickmann A , Martens L . 2012 . Current methods for global proteome identification . Expert Rev Proteomics 9 : 519 – 532 .
Vialás V , Perumal P , Gutierrez D , Ximénez‐Embún P , Nombela C , Gil C , Chaffin WL . 2012 . Cell surface shaving of Candida albicans biofilms, hyphae, and yeast form cells . Proteomics 12 : 2331 – 2339 .
Vizcaíno JA , Côté R , Reisinger F , Foster JM , Mueller M , Rameseder J , Hermjakob H , Martens L . 2009 . A guide to the proteomics identifications database proteomics data repository . Proteomics 9 : 4276 – 4283 .
Voet D , Voet J . 2004 . Biochemistry . New York : John Wiley & Sons .
von Berg A , Koletzko S , Grübl A , Filipiak‐Pittroff B , Wichmann H , Bauer CP , Reinhardt D , Berdel D . 2003 . The effect of hydrolyzed cow's milk formula for allergy prevention in the first year of life: The German Infant Nutritional Intervention Study, a randomized double‐blind trial . J Allergy Clin Immunol 111 : 533 – 540 .
Vorob'ev MM , Dalgalarrondo M , Chobert J , Haertlé T . 2000 . Kinetics of beta‐casein hydrolysis by wild‐type and engineered trypsin . Biopolymers 54 : 355 – 364 .
Vu TK , Hung DT , Wheaton VI , Coughlin SR . 1991 . Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation . Cell 64 : 1057 – 1068 .
Walsh KA , Neurath H . 1964 . Trypsinogen and chymotrypsinogen as homologous proteins . Proc Natl Acad Sci USA 52 : 884 – 889 .
Walter J , Steigemann W , Singh T , Bartunik H , Bode W , Huber R . 1982 . On the disordered activation domain in trypsinogen: Chemical labelling and low‐temperature crystallography . Acta Cryst B38 : 1462 – 1472 .
Walther TC , Mann M . 2010 . Mass spectrometry‐based proteomics in cell biology . J Cell Biol 190 : 491 – 500 .
Washburn MP , Wolters D , Yates JR III. 2001 . Large‐scale analysis of the yeast proteome by multidimensional protein identification technology . Nat Biotechnol 19 : 242 – 247 .
Weil L , Timasheff SN . 1966 . The enzymic activity of trypsin autolysis products . Arch Biochem Biophys 116 : 252 – 254 .
Whitcomb DC , Lowe ME . 2007 . Human pancreatic digestive enzymes . Dig Dis Sci 52 : 1 – 17 .
Wiśniewski JR , Zougman A , Nagaraj N , Mann M . 2009 . Universal sample preparation method for proteome analysis . Nat Methods 6 : 359 – 362 .
Wright HT . 1977 . Secondary and conformational specificities of trypsin and chymotrypsin . Eur J Biochem 73 : 567 – 578 .
Yen C , Russell S , Mendoza AM , Meyer‐Arendt K , Sun S , Cios KJ , Ahn NG , Resing KA . 2006 . Improving sensitivity in shotgun proteomics using a peptide‐centric database with reduced complexity: Protease cleavage and SCX elution rules from data mining of MS/MS spectra . Anal Chem 78 : 1071 – 1084 .
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.