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Effects of IGFBP-1 and IGFBP-2 and their fragments on migration and IGF-induced proliferation of human dermal fibroblasts

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, v.25 no.1, 2015년, pp.34 - 40  

Brandt, K. ,  Grunler, J. ,  Brismar, K. ,  Wang, J.

Abstract AI-Helper 아이콘AI-Helper

Objective: A family of six insulin-like growth factor (IGF) binding-proteins (IGFBP) bind to IGF-I and IGF-II with high affinity and modulate their activity. We have recently shown that a neutrophil-derived protease activity cleaved IGFBP-1, -2 and -4. IGFBP-1 and IGFBP-2 have a C-terminal Arg-Gly-A...

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