$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Robo1/2 regulate follicle atresia through manipulating granulosa cell apoptosis in mice 원문보기

Scientific reports, v.5, 2015년, pp.9720 -   

Li, Jiangchao (Institute of Vascular Biological Sciences, Guangdong Pharmaceutical University , Guangzhou 510006, China) ,  Ye, Yuxiang (Institute of Vascular Biological Sciences, Guangdong Pharmaceutical University , Guangzhou 510006, China) ,  Zhang, Renli (Reproductive Medicine Center, Guangdong General Hospital , Guangzhou 515006, China) ,  Zhang, Lili (Reproductive Medicine Center, Guangdong General Hospital , Guangzhou 515006, China) ,  Hu, Xiwen (Institute of Vascular Biological Sciences, Guangdong Pharmaceutical University , Guangzhou 510006, China) ,  Han, Dong (Reproductive Medicine Center, Guangdong General Hospital , Guangzhou 515006, China) ,  Chen, Jiayuan (Institute of Vascular Biological Sciences, Guangdong Pharmaceutical University , Guangzhou 510006, China) ,  He, Xiaodong (Institute of Vascular Biological Sciences, Guangdong Pharmaceutical University , Guangzhou 510006, China) ,  Wang, Guang (Key Laboratory for Regenerative Medicine of the Ministry of Education, Division of Histology & Embryology, Medical College, Jinan University , Guangzhou 510632, China) ,  Yang, Xuesong (Key Laboratory for Regenerative Medicine) ,  Wang, Lijing

Abstract AI-Helper 아이콘AI-Helper

Secreted Slit proteins and their Roundabout (Robo) receptors act as a repulsive cue to preventaxons from migrating to inappropriate locations during the development of the nervous system. Slit/Robo has also been implicated in reproductive system development, but the molecular mechanism of the Slit/R...

참고문헌 (28)

  1. McGee E. A. & Hsueh A. J. Initial and cyclic recruitment of ovarian follicles . Endocr Rev 21 , 200 – 214 ( 2000 ). 10782364 

  2. Raju G. A. et al. Luteinizing hormone and follicle stimulating hormone synergy: A review of role in controlled ovarian hyper-stimulation . J Hum Reprod Sci 6 , 227 – 234 ( 2013 ). 24672160 

  3. Matsuda F. , Inoue N. , Manabe N. & Ohkura S. Follicular growth and atresia in mammalian ovaries: regulation by survival and death of granulosa cells . J Reprod Dev 58 , 44 – 50 ( 2012 ). 22450284 

  4. Bertoldo M. J. , Bernard J. , Duffard N. , Mermillod P. & Locatelli Y. Regulating pre-antral follicle development: a brake on depletion of the ovarian reserve . Gynecol Obstet Fertil 41 , 540 – 543 ( 2013 ). 23972915 

  5. Rothberg J. M. , Hartley D. A. , Walther Z. & Artavanis-Tsakonas S. slit: an EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system . Cell 55 , 1047 – 1059 ( 1988 ). 3144436 

  6. Seeger M. , Tear G. , Ferres-Marco D. & Goodman C. S. Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline . Neuron 10 , 409 – 426 ( 1993 ). 8461134 

  7. Dickson B. J. Molecular mechanisms of axon guidance . Science 298 , 1959 – 1964 ( 2002 ). 12471249 

  8. Dickson B. J. & Gilestro G. F. Regulation of commissural axon pathfinding by slit and its Robo receptors . Annu Rev Cell Dev Biol. 22 , 651 – 675 ( 2006 ). 17029581 

  9. Hinck L. The versatile roles of “axon guidance” cues in tissue morphogenesis . Dev Cell 7 , 783 – 793 ( 2004 ). 15572123 

  10. Chedotal A. , Kerjan G. & Moreau-Fauvarque C. The brain within the tumor: new roles for axon guidance molecules in cancers . Cell Death Differ 12 , 1044 – 1056 ( 2005 ). 16015381 

  11. Yuan W. et al. The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance . Dev Biol 212 , 290 – 306 ( 1999 ). 10433822 

  12. Piper M. , Georgas K. , Yamada T. & Little M. Expression of the vertebrate Slit gene family and their putative receptors, the Robo genes, in the developing murine kidney . Mech Dev 94 , 213 – 217 ( 2000 ). 10842075 

  13. Dickinson R. E. & Duncan W. C. The SLIT-ROBO pathway: a regulator of cell function with implications for the reproductive system . Reproduction 139 , 697 – 704 ( 2010 ). 20100881 

  14. Dickinson R. E. et al. Involvement of the SLIT/ROBO pathway in follicle development in the fetal ovary . Reproduction 139 , 395 – 407 ( 2010 ). 19900988 

  15. Dickinson R. E. , Myers M. & Duncan W. C. Novel regulated expression of the SLIT/ROBO pathway in the ovary: possible role during luteolysis in women . Endocrinology 149 , 5024 – 5034 ( 2008 ). 18566128 

  16. Meirow D. , Epstein M. , Lewis H. , Nugent D. & Gosden R. G. Administration of cyclophosphamide at different stages of follicular maturation in mice: effects on reproductive performance and fetal malformations . Hum Reprod 16 , 632 – 637 ( 2001 ). 11278209 

  17. Himelstein-Braw R. , Peters H. & Faber M. Morphological study of the ovaries of leukaemic children . Br J Cancer 38 , 82 – 87 ( 1978 ). 687521 

  18. Apperley J. F. & Reddy N. Mechanism and management of treatment-related gonadal failure in recipients of high dose chemoradiotherapy . Blood Rev 9 , 93 – 116 ( 1995 ). 7580395 

  19. Parborell F. , Dain L. & Tesone M. Gonadotropin-releasing hormone agonist affects rat ovarian follicle development by interfering with FSH and growth factors on the prevention of apoptosis . Mol Reprod Dev 60 , 241 – 247 ( 2001 ). 11553925 

  20. Weyers J. J. , Milutinovich A. B. , Takeda Y. , Jemc J. C. & Van Doren M. A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway . Dev Biol 353 , 217 – 228 ( 2011 ). 21377458 

  21. Kalich-Philosoph L. et al. Cyclophosphamide triggers follicle activation and “burnout”; AS101 prevents follicle loss and preserves fertility . Sci Transl Med 5 , 185 ( 2013 ). 

  22. Rolaki A. , Drakakis P. , Millingos S. , Loutradis D. & Makrigiannakis A. Novel trends in follicular development, atresia and corpus luteum regression: a role for apoptosis . Reprod Biomed Online 11 , 93 – 103 ( 2005 ). 16102296 

  23. Hussein M. R. Apoptosis in the ovary: molecular mechanisms . Hum Reprod Update 11 , 162 – 177 ( 2005 ). 15705959 

  24. Amsterdam A. et al. Steroidogenesis and apoptosis in the mammalian ovary . Steroids 68 , 861 – 867 ( 2003 ). 14667978 

  25. Riaz H. , Dong P. , Shahzad M. & Yang L. Constitutive and follicle-stimulating hormone-induced action of somatostatin receptor-2 on regulation of apoptosis and steroidogenesis in bovine granulosa cells . J Steroid Biochem Mol Biol 141 , 150 – 159 ( 2014 ). 24530462 

  26. Yin M. et al. Transactivation of miR-320 by miR-383 regulates granulosa cell functions by targeting E2F1 and SF-1 . J Biol Chem 289 , 18239 – 18257 ( 2014 ). 24828505 

  27. Dorrington J. H. , Bendell J. J. & Khan S. A. Interactions between FSH, estradiol-17 beta and transforming growth factor-beta regulate growth and differentiation in the rat gonad . J Steroid Biochem Mol Biol 44 , 441 – 447 ( 1993 ). 8476758 

  28. Fujiwara M. , Ghazizadeh M. & Kawanami O. Potential role of the Slit/Robo signal pathway in angiogenesis . Vasc Med 11 , 115 – 121 ( 2006 ). 16886842 

관련 콘텐츠

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로