$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

A synthetic chalcone, 2'-hydroxy-2,3,5'-trimethoxychalcone triggers unfolded protein response-mediated apoptosis in breast cancer cells

Cancer letters, v.372 no.1, 2016년, pp.1 - 9  

Lee, D.H. ,  Jung Jung, Y. ,  Koh, D. ,  Lim, Y. ,  Lee, Y.H. ,  Shin, S.Y.

Abstract AI-Helper 아이콘AI-Helper

The primary aim of this study was to find novel chemopreventive agents effective against breast cancer. Endoplasmic reticulum (ER) stress can induce apoptosis through the unfolded protein response (UPR). 2'-Hydroxy-2,3,5'-trimethoxychalcone (DK143) is a synthetic flavonoid derivative. The present st...

주제어

참고문헌 (35)

  1. Genes Dev Kaufman 13 1211 1999 10.1101/gad.13.10.1211 Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls 

  2. Nat. Cell Biol Bertolotti 2 326 2000 10.1038/35014014 Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response 

  3. Science Walter 334 1081 2011 10.1126/science.1209038 The unfolded protein response: from stress pathway to homeostatic regulation 

  4. Cell Death Differ Wu 13 374 2006 10.1038/sj.cdd.4401840 From acute ER stress to physiological roles of the Unfolded Protein Response 

  5. Plant Foods Hum. Nutr Yao 59 113 2004 10.1007/s11130-004-0049-7 Flavonoids in food and their health benefits 

  6. Genes Nutr Orlikova 6 125 2011 10.1007/s12263-011-0210-5 Dietary chalcones with chemopreventive and chemotherapeutic potential 

  7. Eur. J. Med. Chem Mahapatra 98 69 2015 10.1016/j.ejmech.2015.05.004 Anti-cancer chalcones: structural and molecular target perspectives 

  8. J Korean Soc Appl Bi Shin 58 105 2015 10.1007/s13765-015-0017-y The synthetic compound 2 ‘-hydroxy-2,4,6’-trimethoxychalcone overcomes P-glycoprotein-mediated multi-drug resistance in drug-resistant uterine sarcoma MES-SA/DX5 cells 

  9. J. Agric. Food Chem Shin 61 12588 2013 10.1021/jf4034688 Novel Antimitotic Activity of 2-Hydroxy-4-methoxy-2',3'-benzochalcone (HymnPro) through the Inhibition of Tubulin Polymerization 

  10. Cancer Lett Lee 354 348 2014 10.1016/j.canlet.2014.08.041 A new synthetic 2'-hydroxy-2,4,6-trimethoxy-5',6'-naphthochalcone induces G2/M cell cycle arrest and apoptosis by disrupting the microtubular network of human colon cancer cells 

  11. Clin. Cancer Res Shin 20 4302 2014 10.1158/1078-0432.CCR-14-0424 Targeting cancer cells via the reactive oxygen species-mediated unfolded protein response with a novel synthetic polyphenol conjugate 

  12. Magn. Reson. Chem Yong 51 364 2013 10.1002/mrc.3949 1H and 13C NMR spectral assignments of 2'-hydroxychalcones 

  13. Nat. Protoc Franken 1 2315 2006 10.1038/nprot.2006.339 Clonogenic assay of cells in vitro 

  14. Mol. Nutr. Food Res Shin 56 761 2012 10.1002/mnfr.201100651 2'-Hydroxyflavanone induces apoptosis through Egr-1 involving expression of Bax, p21, and NAG-1 in colon cancer cells 

  15. Nature Calfon 415 92 2002 10.1038/415092a IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA 

  16. J. Natl Cancer Inst Ito 98 625 2006 10.1093/jnci/djj161 Autophagic cell death of malignant glioma cells induced by a conditionally replicating adenovirus 

  17. Cell Danial 116 205 2004 10.1016/S0092-8674(04)00046-7 Cell death: critical control points 

  18. Nature Lazebnik 371 346 1994 10.1038/371346a0 Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE 

  19. Apoptosis Kim 17 200 2012 10.1007/s10495-011-0665-2 5-Phenylselenyl- and 5-methylselenyl-methyl-2'-deoxyuridine induce oxidative stress, DNA damage, and caspase-2-dependent apoptosis in cancer cells 

  20. Cancer Cell Schumacker 10 175 2006 10.1016/j.ccr.2006.08.015 Reactive oxygen species in cancer cells: live by the sword, die by the sword 

  21. Nat. Rev. Drug Discov Trachootham 8 579 2009 10.1038/nrd2803 Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? 

  22. Cancer Cell Trachootham 10 241 2006 10.1016/j.ccr.2006.08.009 Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate 

  23. Nature Raj 475 231 2011 10.1038/nature10167 Selective killing of cancer cells by a small molecule targeting the stress response to ROS 

  24. Proc. Natl. Acad. Sci. U.S.A. Adams 109 15115 2012 10.1073/pnas.1212802109 Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs 

  25. Antioxid. Redox Signal Cui 16 1212 2012 10.1089/ars.2012.4532 Reactive oxygen species: the achilles' heel of cancer cells? 

  26. Semin. Immunopathol Kitamura 35 259 2013 10.1007/s00281-013-0371-y The unfolded protein response triggered by environmental factors 

  27. Science Lin 318 944 2007 10.1126/science.1146361 IRE1 signaling affects cell fate during the unfolded protein response 

  28. EMBO J. Ali 30 894 2011 10.1038/emboj.2011.18 Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response 

  29. J. Biol. Chem Li 288 17908 2013 10.1074/jbc.M113.458836 Transmembrane Protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis 

  30. J. Cell Biol Hitomi 165 347 2004 10.1083/jcb.200310015 Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death 

  31. Physiol. Rev Hetz 91 1219 2011 10.1152/physrev.00001.2011 The unfolded protein response: integrating stress signals through the stress sensor IRE1alpha 

  32. Cell Yoshida 107 881 2001 10.1016/S0092-8674(01)00611-0 XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor 

  33. Mol. Cell. Biol McCullough 21 1249 2001 10.1128/MCB.21.4.1249-1259.2001 Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state 

  34. Cell Puthalakath 129 1337 2007 10.1016/j.cell.2007.04.027 ER stress triggers apoptosis by activating BH3-only protein Bim 

  35. J. Cell Sci Fava 125 5911 2012 10.1242/jcs.115105 Caspase-2 at a glance 

LOADING...

관련 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로