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NTIS 바로가기International journal of cosmetic science, v.38 no.2, 2016년, pp.148 - 154
Lee, E. Y. (Department of Biotechnology, CHA University, Seongnam, Korea) , Choi, E.‐J. (Department of Biotechnology, CHA University, Seongnam, Korea) , Kim, J. A. (College of Pharmacy, Kyungpook National University, Daegu, Korea) , Hwang, Y. L. (OBM Laboratory, Daejeon, Korea) , Kim, C.‐D. (Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea) , Lee, M. H. (OBM Laboratory, Daejeon, Korea) , Roh, S. S. (OBM Laboratory, Daejeon, Korea) , Kim, Y. H. (College of Pharmacy, Chungnam National University, Daejeon, Korea) , Han, I. (Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam, Korea) , Kang, S. (Department of Biotechnology, CHA University, Seongnam, Korea)
SynopsisObjectiveMesenchymal–epithelial interactions are important in controlling hair growth and the hair cycle. The β‐catenin pathway of dermal papilla cells (DPCs) plays a pivotal role in morphogenesis and normal regeneration of hair follicles. Deletion of β‐catenin in...
RésuméObjectifLes interactions mésenchymateuses‐ épithéliales sont importantes dans le contrôle de la croissance des cheveux et du cycle pilaire. La voie β‐caténine des cellules des papilles dermiques (CPD) joue un rôle essentiel dans la morphogenèse et la régénération normale des follicules pileux. La suppression de la β‐caténine dans la papille dermique réduit la prolifération des cellules souches du follicule pileux qui génèrent la tige du cheveu et induit une apparition précoce de la phase catagène. Dans cette étude, un modulateur de l'activité/β‐caténine Wnt a été étudiée dans des extraits d'herbes orientales sur CPD humains cultivés.MéthodesL'effet des graines de mauve crépue (Malva verticillata) sur les CPD humaines a été étudié par un système de dosage de l'activité du gène rapporteur Wnt/β‐caténine (TCF‐β‐caténine/gène rapporteur LEF) et l'analyse de la prolifération cellulaire. La synthèse des facteurs liés à la croissance des cheveux et au cycle a été mesurée à la fois au niveau d'ARNm et des protéines par PCR semi‐quantitative et une analyse par Western blot, respectivement.RésultatsUn extrait des graines de M. verticillata a augmenté l'activité de Wnt rapporteur d'une manière dépendante de la concentration et a également conduit à des niveaux accrus de β‐caténine dans les CPD humaines en culture. L'acide myristoléique, identifié comme étant un composé efficace des graines de M. verticillata, a stimulé la prolifération des CPD d'une manière dépendante de la dose ainsi que l'augmentation des niveaux des cibles en aval de l'IGF‐1, KGF, VEGF, HGF et leur transcription. L'acide myristoleïque a également amélioré la phosphorylation des MAPK (Akt et p38).ConclusionGlobalement, les données suggèrent que cet extrait des semences de M. verticillata pourrait être un bon candidat pour le traitement de la perte de cheveux en modulant la voie/β‐caténine dans les CPD.
Yu , B.D. , Mukhopadhyay , A. and Wong , C. Skin and hair: models for exploring organ regeneration . Hum. Mol. Genet. 17 , R54 – R59 ( 2008 ).
Stenn , K.S. and Paus , R. Controls of hair follicle cycling . Physiol. Rev. 81 , 449 – 494 ( 2001 ).
Paus , R. and Foitzik , K. In search of the “hair cycle clock”: a guided tour . Differentiation 72 , 489 – 511 ( 2004 ).
Botchkarev , V.A. and Kishimoto , J. Molecular control of epithelial‐mesenchymal interactions during hair follicle cycling . J. Investig. Dermatol. Symp. Proc. 8 , 46 – 55 ( 2003 ).
Kang , B.M. , Shin , S.H. , Kwack , M.H. et?al . Erythropoietin promotes hair shaft growth in cultured human hair follicles and modulates hair growth in mice . J. Dermatol. Sci. 59 , 86 – 90 ( 2010 ).
Kitagawa , T. , Matsuda , K. , Inui , S. et?al . Keratinocyte growth inhibition through the modification of Wnt signaling by androgen in balding dermal papilla cells . J. Clin. Endocrinol. Metab. 94 , 1288 – 1294 ( 2009 ).
Andl , T. , Reddy , S.T. , Gaddapara , T. and Millar , S.E. WNT signals are required for the initiation of hair follicle development . Dev. Cell 2 , 643 – 653 ( 2002 ).
Kishimoto , J. , Burgeson , R.E. and Morgan , B.A. Wnt signaling maintains the hair‐inducing activity of the dermal papilla . Genes Dev. 14 , 1181 – 1185 ( 2000 ).
Soma , T. , Fujiwara , S. , Shirakata , Y. , Hashimoto , K. and Kishimoto , J. Hair‐inducing ability of human dermal papilla cells cultured under Wnt/ β ‐catenin signalling activation . Exp. Dermatol. 21 , 307 – 309 ( 2012 ).
Tsai , S.Y. , Sennett , R. , Rezza , A. et?al . Wnt/ β ‐catenin signaling in dermal condensates is required for hair follicle formation . Dev. Biol. 385 , 179 – 188 ( 2014 ).
Reddy , S. , Andl , T. , Bagasra , A. , Lu , M.M. , Epstein , D.J. , Morrisey , E.E. , Millar , S.E. Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis . Mech. Dev. 107 , 69 – 82 ( 2001 ).
Arck , P.C. , Handjiski , B. , Peters , E.M. et?al . Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P‐dependent pathways . Am. J. Pathol. 162 , 803 – 814 ( 2003 ).
Famenini , S. and Goh , C. Evidence for supplemental treatments in androgenetic alopecia . J. Drugs Dermatol. 13 , 809 – 812 ( 2014 ).
Shin , H.S. , Park , S.Y. , Song , H.G. , Hwang , E. , Lee , D.G. and Yi , T.H. The androgenic alopecia protective effects of forsythiaside‐A and the molecular regulation in a mouse?model . Phytother. Res. 29 , 870 – 876 ( 2015 ).
Kim , J.A. , Yang , S.Y. , Kang , S. and Kim , Y.H. Verticilloside, a New Daucosteryl Derivative from the Seeds of Malva verticillata . Nat. Prod. Sci. 17 , 350 – 353 ( 2011 ).
Kim , C.D. , Lee , M.H. and Roh , S.S. Identification of androgen‐regulated genes in SV40‐transformed human hair dermal papilla cells . J. Dermatol. Sci. 32 , 143 – 149 ( 2003 ).
Kovganko , N.V. , Kashkan , Zh.N. , Borisov , E.V. and Batura , E.V. 13C NMR spectra of β ‐sitosterol derivatives with oxidized rings A and B . Chem. Nat. Comp. 35 , 646 – 649 ( 1999 ).
Voutquenne , L. , Lavaud , C. , Massiot , G. , Sevenet , T. and Hadi , H.A. Cytotoxic polyisoprenes and glycosides of long‐chain fatty alcohols from Dimocarpus fumatus . Phytochemistry 50 , 63 – 69 ( 1999 ).
De Bruyn , A. and Van Loo , J. The identification by 1 H‐and 13 C‐n. m.r spectroscopy of sucrose, 1‐kestose, and neokestose in mixtures present in plant extracts . Carbohydr. Res. 211 , 131 – 136 ( 1991 ).
Wu , Q. , Chen , Z.C. , Lu , D.S. and Lin , X.F. Chemo? Enzymatic synthesis of raffinose? Branched polyelectrolytes and self? Assembly application in microcapsules . Macromol. Biosci. 6 , 78 – 83 ( 2006 ).
Vlahov , G. 13C nuclear magnetic resonance spectroscopic detection of the adulteration of extra virgin olive oils extracted from different cultivars with cold‐pressed hazelnut oil . J AOAC Int . 92 , 1747 – 1754 ( 2009 ).
Elliott , K. , Stephenson , T.J. and Messenger , A.G. Differences in hair follicle dermal papilla volume are due to extracellular matrix volume and cell number: implications for the control of hair follicle size and androgen responses . J. Invest Dermatol. 113 , 873 – 877 ( 1999 ).
Jenis , D.M. , Keyes , S.R. and Sartorelli , A.C. Induction of the differentiation of HL‐60 promyelocytic leukemia cells by palmitoleic and myristoleic acids . Leuk. Res. 11 , 935 – 939 ( 1987 ).
Kong , C.Y. , Mori , M. , Funazukuri , T. and Kagei , S. Measurements of binary diffusion coefficients, retention factors and partial molar volumes for myristoleic acid and its methyl ester in supercritical carbon dioxide . Anal. Sci. 22 , 1431 – 1436 ( 2006 ).
Iguchi , K. , Okumura , N. , Usui , S. , Sajiki , H. , Hirota , K. and Hirano , K. Myristoleic acid, a cytotoxic component in the extract from Serenoa repens, induces apoptosis and necrosis in human prostatic LNCaP cells . Prostate 47 , 59 – 65 ( 2001 ).
Liao , S. , Lin , J. , Dang , M.T. , Zhang , H. , Kao , Y.H. , Fukuchi , J. , Hiipakka , R.A. Growth suppression of hamster flank organs by topical application of catechins, alizarin, curcumin, and myristoleic acid . Arch. Dermatol. Res. 293 , 200 – 205 ( 2001 ).
Taurin , S. , Sandbo , N. , Qin , Y. , Browning , D. and Dulin , N.O. Phosphorylation of beta‐catenin by cyclic AMP‐dependent protein kinase . J. Biol. Chem. 281 , 9971 – 9976 ( 2006 ).
Yun , M.S. , Kim , S.E. , Jeon , S.H. , Lee , J.S. and Choi , K.Y. Both ERK and Wnt/beta‐catenin pathways are involved in Wnt3a‐induced proliferation . J. Cell Sci. 118 , 313 – 322 ( 2005 ).
Barker , N. and Clevers , H. Mining the Wnt pathway for cancer therapeutics . Nat. Rev. Drug Discov. 5 , 997 – 1014 ( 2006 ).
Philpott , M.P. , Sanders , D.A. and Kealey , T. Effects of insulin and insulin‐like growth factors on cultured human hair follicles: IGF‐I at physiologic concentrations is an important regulator of hair follicle growth in?vitro . J. Invest Dermatol. 102 , 857 – 861 ( 1994 ).
Weger , N. and Schlake , T. Igf‐I signalling controls the hair growth cycle and the differentiation of hair shafts . J. Invest Dermatol. 125 , 873 – 882 ( 2005 ).
Danilenko , D.M. , Ring , B.D. , Yanagihara , D. , Benson , W. , Wiemann , B. , Starnes , C.O. , Pierce , G.F. Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy‐induced alopecia . Am. J. Pathol. 147 , 145 – 154 ( 1995 ).
Yano , K. , Brown , L.F. and Detmar , M. Control of hair growth and follicle size by VEGF‐mediated angiogenesis . J. Clin. Invest. 107 , 409 – 417 ( 2001 ).
Lee , Y.R. , Yamazaki , M. , Mitsui , S. , Tsuboi , R. and Ogawa , H. Hepatocyte growth factor (HGF) activator expressed in hair follicles is involved in in?vitro HGF‐dependent hair follicle elongation . J. Dermatol. Sci. 25 , 156 – 163 ( 2001 ).
Freyberg , Z. , Ferrando , S.J. and Javitch , J.A. Roles of the Akt/GSK‐3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action . Am. J. Psychiatry 167 , 388 – 396 ( 2010 ).
Shin , S.Y. , Rath , O. , Zebisch , A. , Choo , S.M. , Kolch , W. and Cho , K.H. Functional roles of multiple feedback loops in extracellular signal‐regulated kinase and Wnt signaling pathways that regulate epithelial‐mesenchymal transition . Cancer Res. 70 , 6715 – 6724 ( 2010 ).
Bikkavilli , R.K. , Feigin , M.E. and Malbon , C.C. p38 mitogen‐activated protein kinase regulates canonical Wnt‐beta‐catenin signaling by inactivation of GSK3beta . J. Cell Sci. 121 , 3598 – 3607 ( 2008 ).
Caverzasio , J. and Manen , D. Essential role of Wnt3a‐mediated activation of mitogen‐activated protein kinase p38 for the stimulation of alkaline phosphatase activity and matrix mineralization in C3H10T1/2 mesenchymal cells . Endocrinology 148 , 5323 – 5330 ( 2007 ).
Ma , L. and Wang , H.Y. Mitogen‐activated protein kinase p38 regulates the Wnt/cyclic GMP/Ca2+ non‐canonical pathway . J.?Biol. Chem. 282 , 28980 – 28990 ( 2007 ).
Chen , A.E. , Ginty , D.D. and Fan , C.M. Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins . Nature 433 , 317 – 322 ( 2005 ).
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