[논문]Shea butter solid nanoparticles for curcumin encapsulation: Influence of nanoparticles size on drug loading

Hajj Ali, Hassan; Michaux, Florentin; Bouelet Ntsama, Isabelle Sandrine; Durand, Pierrick; Jasniewski, Jordane; Linder, Michel

doi:10.1002/ejlt.201500348

Shea butter solid nanoparticles for curcumin encapsulation: Influence of nanoparticles size on drug loading 원문보기

European journal of lipid science and technology : EJLST, v.118 no.8, 2016년, pp.1168 - 1178

Hajj Ali, Hassan (Université) , Michaux, Florentin (de Lorraine, LIBio (Laboratoire d'Ingé) , Bouelet Ntsama, Isabelle Sandrine (nierie des Biomolé) , Durand, Pierrick (cules), Vandoeuvre‐) , Jasniewski, Jordane (lè) , Linder, Michel (s‐)

Abstract ▼ AI-Helper

In the present work, shea butter solid lipid nanoparticles (SLN) were prepared by sonication using nonionic surfactants as stabilizers without organic solvent. The mixture design methodology enabled to control particles size from 50 nm to more than 1 μm according to the mixture composition. Then, curcumin, a natural polyphenol, has been encapsulated in nanoparticles with a wide range of diameters (50–230 nm) and the encapsulation efficiency has been related to the particles sizes. The bigger the nanoparticles, the lower the encapsulation efficiency. The lipid structure at non dispersed state and under SLN form has been studied by differential scanning calorimetry and X‐ray diffraction. From the obtained results, encapsulated curcumin did not affect the lipid properties at the SLN state unlike at non dispersed state. The localization of the curcumin in the outer shell of the lipid nanoparticles explained the evolution of the encapsulation efficiency according to the nanoparticles size.Practical applications: Solid lipid nanoparticles (SLN) can be used for the delivery of both hydrophobic and hydrophilic drugs. Preparing such nanovectors with natural, non‐expensive materials and easily available (i.e., shea butter) will promote their potential use in several applications like oral, parenteral, dermal or ocular delivery. Controlling the particles size from the formulation composition and also the drug loading from SLN properties is of main importance to optimize the use of SLN as colloidal carrier.Mixture design of experiments methodology allowed the control of shea butter solid lipid nanoparticles size upon system composition. The influence of SLN size on the encapsulation efficiency of curcumin was studied.

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참고문헌 (33)

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Shea butter solid nanoparticles for curcumin encapsulation: Influence of nanoparticles size on drug loading 원문보기

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