[논문]Obesity and Subtypes of Incident Cardiovascular Disease

Ndumele, Chiadi E.; Matsushita, Kunihiro; Lazo, Mariana; Bello, Natalie; Blumenthal, Roger S.; Gerstenblith, Gary; Nambi, Vijay; Ballantyne, Christie M.; Solomon, Scott D.; Selvin, Elizabeth; Folsom, Aaron R.; Coresh, Josef

doi:10.1161/JAHA.116.003921

Obesity and Subtypes of Incident Cardiovascular Disease 원문보기

Journal of the American Heart Association : cardiovascular and cerebrovascular disease, v.5 no.8, 2016년, pp.e003921 -

Ndumele, Chiadi E. (Johns Hopkins Ciccarone Center for the Prevention of Heart Disease Johns Hopkins University School of Medicine Baltimore MD) , Matsushita, Kunihiro (Department of Epidemiology and the Welch Center for Prevention, Epidemiology, and Clinical Research Johns Hopkins Bloomberg School of Public Health Baltimore MD) , Lazo, Mariana (Department of General Internal Medicine Johns Hopkins University School of Medicine Baltimore MD) , Bello, Natalie (Division of Cardiology Columbia University Medical Center New York NY) , Blumenthal, Roger S. (Johns Hopkins Ciccarone Center for the Prevention of Heart Disease Johns Hopkins University School of Medicine Baltimore MD) , Gerstenblith, Gary (Johns Hopkins Ciccarone Center for the Prevention of Heart Disease Johns Hopkins University School of Medicine Baltimore MD) , Nambi, Vijay (Michael E DeBakey Veterans Affairs Hospital Houston TX) , Ballantyne, Christie M. (Division of Atherosclerosis and Vascular Medicine Baylor College of Medicine, and Center for Cardiovascular Disease Prevention Methodist DeBakey Heart and Vascular Center Houston TX) , Solomon, Scott D. (Division of Cardiology Brigham and Womens’ Ho) , Selvin, Elizabeth , Folsom, Aaron R. , Coresh, Josef

Abstract ▼ AI-Helper

BackgroundObesity is a risk factor for various subtypes of cardiovascular disease (CVD), including coronary heart disease (CHD), heart failure (HF), and stroke. Nevertheless, there are limited comparisons of the associations of obesity with each of these CVD subtypes, particularly regarding the extent to which they are unexplained by traditional CVD mediators.Methods and ResultsWe followed 13 730 participants in the Atherosclerosis Risk in Communities (ARIC) study who had a body mass index ≥18.5 and no CVD at baseline (visit 1, 1987–1989). We compared the association of higher body mass index with incident HF, CHD, and stroke before and after adjusting for traditional CVD mediators (including systolic blood pressure, diabetes mellitus, and lipid measures). Over a median follow‐up of 23 years, there were 2235 HF events, 1653 CHD events, and 986 strokes. After adjustment for demographics, smoking, physical activity, and alcohol intake, higher body mass index had the strongest association with incident HF among CVD subtypes, with hazard ratios for severe obesity (body mass index ≥35 versus normal weight) of 3.74 (95% CI 3.24–4.31) for HF, 2.00 (95% CI 1.67–2.40) for CHD, and 1.75 (95% CI 1.40–2.20) for stroke (P<0.0001 for comparisons of HF versus CHD or stroke). Further adjustment for traditional mediators fully explained the association of higher body mass index with CHD and stroke but not with HF (hazard ratio 2.27, 95% CI 1.94–2.64).ConclusionsThe link between obesity and HF was stronger than those for other CVD subtypes and was uniquely unexplained by traditional risk factors. Weight management is likely critical for optimal HF prevention, and nontraditional pathways linking obesity to HF need to be elucidated.

참고문헌 (48)

1 Poirier P , Giles TD , Bray GA , Hong Y , Stern JS , Pi‐Sunyer FX , Eckel RH . Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism . Circulation . 2006 ; 113 : 898 – 918 . 16380542
2 Zalesin KC , Franklin BA , Miller WM , Peterson ED , McCullough PA . Impact of obesity on cardiovascular disease . Med Clin North Am . 2011 ; 95 : 919 – 937 . 21855700

상세보기
3 Pandey A , Berry JD , Lavie CJ . Cardiometabolic disease leading to heart failure: better fat and fit than lean and lazy . Curr Heart Fail Rep . 2015 ; 12 : 302 – 308 . 26298463
4 Aune D , Sen A , Norat T , Janszky I , Romundstad P , Tonstad S , Vatten LJ . Body mass index, abdominal fatness, and heart failure incidence and mortality: a systematic review and dose‐response meta‐analysis of prospective studies . Circulation . 2016 ; 133 : 639 – 649 . 26746176

상세보기
5 Davis MP , Rhode PC , Dutton GR , Redmann SM , Ryan DH , Brantley PJ . A primary care weight management intervention for low‐income African‐American women . Obesity (Silver Spring) . 2006 ; 14 : 1412 – 1420 . 16988084
6 Kraschnewski JL , Boan J , Esposito J , Sherwood NE , Lehman EB , Kephart DK , Sciamanna CN . Long‐term weight loss maintenance in the United States . Int J Obes (Lond) . 2010 ; 34 : 1644 – 1654 . 20479763

상세보기
7 Martin PD , Dutton GR , Rhode PC , Horswell RL , Ryan DH , Brantley PJ . Weight loss maintenance following a primary care intervention for low‐income minority women . Obesity (Silver Spring) . 2008 ; 16 : 2462 – 2467 . 18787526
8 Ockene IS , Hebert JR , Ockene JK , Saperia GM , Stanek E , Nicolosi R , Merriam PA , Hurley TG . Effect of physician‐delivered nutrition counseling training and an office‐support program on saturated fat intake, weight, and serum lipid measurements in a hyperlipidemic population: Worcester Area Trial for Counseling in Hyperlipidemia (WATCH) . Arch Intern Med . 1999 ; 159 : 725 – 731 . 10218753
9 Bodenant M , Kuulasmaa K , Wagner A , Kee F , Palmieri L , Ferrario MM , Montaye M , Amouyel P , Dallongeville J . Measures of abdominal adiposity and the risk of stroke: the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) study . Stroke . 2011 ; 42 : 2872 – 2877 . 21836099

상세보기
10 Calle EE , Thun MJ , Petrelli JM , Rodriguez C , Heath CW Jr . Body‐mass index and mortality in a prospective cohort of U.S. adults . N Engl J Med . 1999 ; 341 : 1097 – 1105 . 10511607

상세보기
11 Empana JP , Ducimetiere P , Charles MA , Jouven X . Sagittal abdominal diameter and risk of sudden death in asymptomatic middle‐aged men: the Paris Prospective Study I . Circulation . 2004 ; 110 : 2781 – 2785 . 15492315

상세보기
12 Garrison RJ , Castelli WP . Weight and thirty‐year mortality of men in the Framingham Study . Ann Intern Med . 1985 ; 103 : 1006 – 1009 . 4062116

상세보기
13 Hubert HB , Feinleib M , McNamara PM , Castelli WP . Obesity as an independent risk factor for cardiovascular disease: a 26‐year follow‐up of participants in the Framingham Heart Study . Circulation . 1983 ; 67 : 968 – 977 . 6219830

상세보기
14 Manson JE , Willett WC , Stampfer MJ , Colditz GA , Hunter DJ , Hankinson SE , Hennekens CH , Speizer FE . Body weight and mortality among women . N Engl J Med . 1995 ; 333 : 677 – 685 . 7637744

상세보기
15 Suk SH , Sacco RL , Boden‐Albala B , Cheun JF , Pittman JG , Elkind MS , Paik MC . Abdominal obesity and risk of ischemic stroke: the Northern Manhattan Stroke Study . Stroke . 2003 ; 34 : 1586 – 1592 . 12775882

상세보기
16 Folsom AR , Stevens J , Schreiner PJ , McGovern PG . Body mass index, waist/hip ratio, and coronary heart disease incidence in African Americans and whites. Atherosclerosis Risk in Communities Study Investigators . Am J Epidemiol . 1998 ; 148 : 1187 – 1194 . 9867265

상세보기
17 Jousilahti P , Tuomilehto J , Vartiainen E , Pekkanen J , Puska P . Body weight, cardiovascular risk factors, and coronary mortality. 15‐year follow‐up of middle‐aged men and women in eastern Finland . Circulation . 1996 ; 93 : 1372 – 1379 . 8641026

상세보기
18 Schulte H , Cullen P , Assmann G . Obesity, mortality and cardiovascular disease in the Munster Heart Study (PROCAM) . Atherosclerosis . 1999 ; 144 : 199 – 209 . 10381293
19 Tanizaki Y , Kiyohara Y , Kato I , Iwamoto H , Nakayama K , Shinohara N , Arima H , Tanaka K , Ibayashi S , Fujishima M . Incidence and risk factors for subtypes of cerebral infarction in a general population: the Hisayama study . Stroke . 2000 ; 31 : 2616 – 2622 . 11062284

상세보기
20 Wang C , Liu Y , Yang Q , Dai X , Wu S , Wang W , Ji X , Li L , Fang X . Body mass index and risk of total and type‐specific stroke in Chinese adults: results from a longitudinal study in China . Int J Stroke . 2013 ; 8 : 245 – 250 . 23039874

상세보기
21 Wormser D , Kaptoge S , Di AE , Wood AM , Pennells L , Thompson A , Sarwar N , Kizer JR , Lawlor DA , Nordestgaard BG , Ridker P , Salomaa V , Stevens J , Woodward M , Sattar N , Collins R , Thompson SG , Whitlock G , Danesh J . Separate and combined associations of body‐mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies . Lancet . 2011 ; 377 : 1085 – 1095 . 21397319
22 Yatsuya H , Yamagishi K , North KE , Brancati FL , Stevens J , Folsom AR . Associations of obesity measures with subtypes of ischemic stroke in the ARIC Study . J Epidemiol . 2010 ; 20 : 347 – 354 . 20595781
23 Markus HS , Khan U , Birns J , Evans A , Kalra L , Rudd AG , Wolfe CD , Jerrard‐Dunne P . Differences in stroke subtypes between black and white patients with stroke: the South London Ethnicity and Stroke Study . Circulation . 2007 ; 116 : 2157 – 2164 . 17967776

상세보기
24 Kurth T , Gaziano JM , Rexrode KM , Kase CS , Cook NR , Manson JE , Buring JE . Prospective study of body mass index and risk of stroke in apparently healthy women . Circulation . 2005 ; 111 : 1992 – 1998 . 15837954

상세보기
25 Lu Y , Hajifathalian K , Ezzati M , Woodward M , Rimm EB , Danaei G . Metabolic mediators of the effects of body‐mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1.8 million participants . Lancet . 2014 ; 383 : 970 – 983 . 24269108
26 Del Gobbo LC , Kalantarian S , Imamura F , Lemaitre R , Siscovick DS , Psaty BM , Mozaffarian D . Contribution of major lifestyle risk factors for incident heart failure in older adults: the Cardiovascular Health Study . JACC Heart Fail . 2015 ; 3 : 520 – 528 . 26160366
27 Kenchaiah S , Evans JC , Levy D , Wilson PW , Benjamin EJ , Larson MG , Kannel WB , Vasan RS . Obesity and the risk of heart failure . N Engl J Med . 2002 ; 347 : 305 – 313 . 12151467

상세보기
28 Morkedal B , Vatten LJ , Romundstad PR , Laugsand LE , Janszky I . Risk of myocardial infarction and heart failure among metabolically healthy but obese individuals: HUNT (Nord‐Trondelag Health Study), Norway . J Am Coll Cardiol . 2014 ; 63 : 1071 – 1078 . 24345592
29 Wannamethee SG , Shaper AG , Whincup PH , Lennon L , Sattar N . Obesity and risk of incident heart failure in older men with and without pre‐existing coronary heart disease: does leptin have a role? J Am Coll Cardiol . 2011 ; 58 : 1870 – 1877 . 22018297
30 Abel ED , Litwin SE , Sweeney G . Cardiac remodeling in obesity . Physiol Rev . 2008 ; 88 : 389 – 419 . 18391168

상세보기
31 Alpert MA , Omran J , Mehra A , Ardhanari S . Impact of obesity and weight loss on cardiac performance and morphology in adults . Prog Cardiovasc Dis . 2014 ; 56 : 391 – 400 . 24438730

상세보기
32 The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators . Am J Epidemiol . 1989 ; 129 : 687 – 702 . 2646917
33 Friedewald WT , Levy RI , Fredrickson DS . Estimation of the concentration of low‐density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge . Clin Chem . 1972 ; 18 : 499 – 502 . 4337382

상세보기
34 Rosamond WD , Chang PP , Baggett C , Johnson A , Bertoni AG , Shahar E , Deswal A , Heiss G , Chambless LE . Classification of heart failure in the atherosclerosis risk in communities (ARIC) study: a comparison of diagnostic criteria . Circ Heart Fail . 2012 ; 5 : 152 – 159 . 22271752

상세보기
35 Zellner A . An efficient method of estimating seemingly unrelated regressions and tests for aggregation bias . J Am Stat Assoc . 1962 ; 57 : 348 – 368 .

상세보기
36 Lavie CJ , McAuley PA , Church TS , Milani RV , Blair SN . Obesity and cardiovascular diseases: implications regarding fitness, fatness, and severity in the obesity paradox . J Am Coll Cardiol . 2014 ; 63 : 1345 – 1354 . 24530666
37 Turkbey EB , McClelland RL , Kronmal RA , Burke GL , Bild DE , Tracy RP , Arai AE , Lima JA , Bluemke DA . The impact of obesity on the left ventricle: the Multi‐Ethnic Study of Atherosclerosis (MESA) . JACC Cardiovasc Imaging . 2010 ; 3 : 266 – 274 . 20223423
38 Frankel DS , Vasan RS , D'Agostino RB Sr , Benjamin EJ , Levy D , Wang TJ , Meigs JB . Resistin, adiponectin, and risk of heart failure the Framingham Offspring Study . J Am Coll Cardiol . 2009 ; 53 : 754 – 762 . 19245965
39 Karas MG , Benkeser D , Arnold AM , Bartz TM , Djousse L , Mukamal KJ , Ix JH , Zieman SJ , Siscovick DS , Tracy RP , Mantzoros CS , Gottdiener JS , deFilippi CR , Kizer JR . Relations of plasma total and high‐molecular‐weight adiponectin to new‐onset heart failure in adults >/=65 years of age (from the Cardiovascular Health Study) . Am J Cardiol . 2014 ; 113 : 328 – 334 . 24169012

상세보기
40 McManus DD , Lyass A , Ingelsson E , Massaro JM , Meigs JB , Aragam J , Benjamin EJ , Vasan RS . Relations of circulating resistin and adiponectin and cardiac structure and function: the Framingham Offspring Study . Obesity (Silver Spring) . 2012 ; 20 : 1882 – 1886 . 21350435
41 Negi SI , Jeong EM , Shukrullah I , Raicu M , Dudley SC Jr . Association of low plasma adiponectin with early diastolic dysfunction . Congest Heart Fail . 2012 ; 18 : 187 – 191 . 22809257

상세보기
42 Garg S , Narula J , Chandrashekhar Y . Apoptosis and heart failure: clinical relevance and therapeutic target . J Mol Cell Cardiol . 2005 ; 38 : 73 – 79 . 15623423

상세보기
43 Ndumele CE , Coresh J , Lazo M , Hoogeveen RC , Blumenthal RS , Folsom AR , Selvin E , Ballantyne CM , Nambi V . Obesity, subclinical myocardial injury, and incident heart failure . JACC Heart Fail . 2014 ; 2 : 600 – 607 . 25443112
44 Zhou YT , Grayburn P , Karim A , Shimabukuro M , Higa M , Baetens D , Orci L , Unger RH . Lipotoxic heart disease in obese rats: implications for human obesity . Proc Natl Acad Sci USA . 2000 ; 97 : 1784 – 1789 . 10677535

상세보기
45 Barouch LA , Gao D , Chen L , Miller KL , Xu W , Phan AC , Kittleson MM , Minhas KM , Berkowitz DE , Wei C , Hare JM . Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity . Circ Res . 2006 ; 98 : 119 – 124 . 16339484

상세보기
46 Lavie CJ , Alpert MA , Arena R , Mehra MR , Milani RV , Ventura HO . Impact of obesity and the obesity paradox on prevalence and prognosis in heart failure . JACC Heart Fail . 2013 ; 1 : 93 – 102 . 24621833
47 Clark AL , Fonarow GC , Horwich TB . Obesity and the obesity paradox in heart failure . Prog Cardiovasc Dis . 2014 ; 56 : 409 – 414 . 24438732

상세보기
48 Lavie CJ , Sharma A , Alpert MA , De SA , Lopez‐Jimenez F , Milani RV , Ventura HO . Update on obesity and obesity paradox in heart failure . Prog Cardiovasc Dis . 2016 ; 58 : 393 – 400 . 26721180

상세보기

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Obesity and Subtypes of Incident Cardiovascular Disease 원문보기

Abstract ▼ AI-Helper

참고문헌 (48)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트