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[해외논문] Novel pyrimidine-2,4-dione-1,2,3-triazole and furo[2,3-d]pyrimidine-2-one-1,2,3-triazole hybrids as potential anti-cancer agents: Synthesis, computational and X-ray analysis and biological evaluation

European journal of medicinal chemistry, v.125, 2017년, pp.1247 - 1267  

Gregoric, T. ,  Sedic, M. ,  Grbcic, P. ,  Tomljenovic Paravic, A. ,  Kraljevic Pavelic, S. ,  Cetina, M. ,  Vianello, R. ,  Raic-Malic, S.

Abstract AI-Helper 아이콘AI-Helper

Regioselective 1,4-disubstituted 1,2,3-triazole tethered pyrimidine-2,4-dione derivatives (5-23) were successfully prepared by the copper(I)-catalyzed click chemistry. While known palladium/copper-cocatalyzed method based on Sonogashira cross-coupling followed by the intramolecular 5-endo-dig ring c...

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