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Inflammasome-Derived Exosomes Activate NF-κB Signaling in Macrophages

Journal of proteome research, v.16 no.1, 2017년, pp.170 - 178  

Zhang, Yuehui (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206,) ,  Liu, Fangbing (Anhui Medical University, Hefei, Anhui 230032,) ,  Yuan, Yanzhi (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206,) ,  Jin, Chaozhi (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206,) ,  Chang, Cheng (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206,) ,  Zhu, Yunping (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206,) ,  Zhang, Xiuyuan (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206,) ,  Tian, Chunyan (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206,) ,  He, Fuchu (State Key Laboratory of Proteomics, Beijing Prot) ,  Wang, Jian

Abstract AI-Helper 아이콘AI-Helper

Exosomes are secreted small vesicles that mediate various biological processes, such as tumorigenesis and immune response. However, whether the inflammasome signaling leads to the change of constituent of exosomes and its roles in immune response remains to be determined. We isolated the exosomes fr...

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참고문헌 (49)

  1. Martinon, Fabio, Burns, Kimberly, Tschopp, Jürg. The Inflammasome : A Molecular Platform Triggering Activation of Inflammatory Caspases and Processing of proIL-β. Molecular cell, vol.10, no.2, 417-426.

  2. Martinon, Fabio, Mayor, Annick, Tschopp, J체rg. The Inflammasomes: Guardians of the Body. Annual review of immunology, vol.27, 229-265.

  3. Schroder, Kate, Tschopp, Jurg. The Inflammasomes. Cell, vol.140, no.6, 821-832.

  4. Guo, Haitao, Callaway, Justin B, Ting, Jenny P-Y. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nature medicine, vol.21, no.7, 677-687.

  5. Shi, Jianjin, Zhao, Yue, Wang, Kun, Shi, Xuyan, Wang, Yue, Huang, Huanwei, Zhuang, Yinghua, Cai, Tao, Wang, Fengchao, Shao, Feng. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature, vol.526, no.7575, 660-665.

  6. Kayagaki, Nobuhiko, Stowe, Irma B., Lee, Bettina L., O’Rourke, Karen, Anderson, Keith, Warming, Søren, Cuellar, Trinna, Haley, Benjamin, Roose-Girma, Merone, Phung, Qui T., Liu, Peter S., Lill, Jennie R., Li, Hong, Wu, Jiansheng, Kummerfeld, Sarah, Zhang, Juan, Lee, Wyne P., Snipas, Scott J., Salvesen, Guy S., Morris, Lucy X., Fitzgerald, Linda, Zhang, Yafei, Bertram, Edward M., Goodnow, Christopher C., Dixit, Vishva M.. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature, vol.526, no.7575, 666-671.

  7. Davis, Beckley K., Wen, Haitao, Ting, Jenny P.-Y.. The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases. Annual review of immunology, vol.29, 707-735.

  8. Rathinam, Vijay A K, Vanaja, Sivapriya Kailasan, Fitzgerald, Katherine A. Regulation of inflammasome signaling. Nature immunology, vol.13, no.4, 333-332.

  9. Bryan, Nicole B., Dorfleutner, Andrea, Rojanasakul, Yon, Stehlik, Christian. Activation of Inflammasomes Requires Intracellular Redistribution of the Apoptotic Speck-Like Protein Containing a Caspase Recruitment Domain. The journal of immunology : official journal of the American Association of Immunologists, vol.182, no.5, 3173-3182.

  10. Franklin, Bernardo S., Bossaller, Lukas, De Nardo, Dominic, Ratter, Jacqueline M., Stutz, Andrea, Engels, Gudrun, Brenker, Christoph, Nordhoff, Mark, Mirandola, Sandra R., Al-Amoudi, Ashraf, Mangan, Matthew, Zimmer, Sebastian, Monks, Brian, Fricke, Martin, Schmidt, Reinhold E., Espevik, Terje, Jones, Bernadette, Jarnicki, Andrew G., Hansbro, Philip M., Busto, Patricia, Marshak-Rothstein, Ann, Hornemann, Simone, Aguzzi, Adriano, Kastenmüller, Wolfgang, Latz, Eicke. ASC has extracellular and prionoid activities that propagate inflammation. Nature immunology, vol.15, no.8, 727-737.

  11. Yang, C.A., Chiang, B.L.. Inflammasomes and human autoimmunity: A comprehensive review. Journal of autoimmunity, vol.61, 1-8.

  12. Heneka, Michael T., Kummer, Markus P., Stutz, Andrea, Delekate, Andrea, Schwartz, Stephanie, Saecker, Ana, Griep, Angelika, Axt, Daisy, Remus, Anita, Tzeng, Te-Chen, Gelpi, Ellen, Halle, Annett, Korte, Martin, Latz, Eicke, Golenbock, Douglas. NLRP3 is activated in Alzheimer´s disease and contributes to pathology in APP/PS1 mice. Nature, vol.493, no.7434, 674-678.

  13. de Rivero Vaccari, Juan Pablo, Brand III, Frank, Adamczak, Stephanie, Lee, Stephanie W., Perez‐Barcena, Jon, Wang, Michael Y., Bullock, M. Ross, Dietrich, W. Dalton, Keane, Robert W.. Exosome‐mediated inflammasome signaling after central nervous system injury. Journal of neurochemistry, vol.136, no.suppl1, 39-48.

  14. Raposo, Graça, Stoorvogel, Willem. Extracellular vesicles: Exosomes, microvesicles, and friends. The Journal of cell biology, vol.200, no.4, 373-383.

  15. Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes. Seminars in cell & developmental biology, vol.40, 41-51.

  16. Théry, Clotilde. Exosomes: secreted vesicles and intercellular communications. F1000 biology reports, vol.3, 15-.

  17. Pan, B T, Teng, K, Wu, C, Adam, M, Johnstone, R M. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. The Journal of cell biology, vol.101, no.3, 942-948.

  18. Qu, L., Ding, J., Chen, C., Wu, Z.J., Liu, B., Gao, Y., Chen, W., Liu, F., Sun, W., Li, X.F., Wang, X., Wang, Y., Xu, Z.Y., Gao, L., Yang, Q., Xu, B., Li, Y.M., Fang, Z.Y., Xu, Z.P., Bao, Y., Wu, D.S., Miao, X., Sun, H.Y., Sun, Y.H., Wang, H.Y., Wang, L.H.. Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA. Cancer cell, vol.29, no.5, 653-668.

  19. Kourembanas, Stella. Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy. Annual review of physiology, vol.77, 13-27.

  20. Boelens, Mirjam C., Wu, Tony J., Nabet, Barzin Y., Xu, B., Qiu, Y., Yoon, T., Azzam, Diana J., Twyman-Saint Victor, C., Wiemann, Brianne Z., Ishwaran, H., ter Brugge, Petra J., Jonkers, J., Slingerland, J., Minn, Andy J.. Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways. Cell, vol.159, no.3, 499-513.

  21. Melo, Sonia A., Sugimoto, H., O'Connell, Joyce T., Kato, N., Villanueva, A., Vidal, A., Qiu, L., Vitkin, E., Perelman, Lev T., Melo, Carlos A., Lucci, A., Ivan, C., Calin, George A., Kalluri, R.. Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis. Cancer cell, vol.26, no.5, 707-721.

  22. Alexander, Margaret, Hu, Ruozhen, Runtsch, Marah C., Kagele, Dominique A., Mosbruger, Timothy L., Tolmachova, Tanya, Seabra, Miguel C., Round, June L., Ward, Diane M., O'Connell, Ryan M.. Exosome-delivered microRNAs modulate the inflammatory response to endotoxin. Nature communications, vol.6, 7321-.

  23. Qu, Yan, Franchi, Luigi, Nunez, Gabriel, Dubyak, George R.. Nonclassical IL-1β Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages. The journal of immunology : official journal of the American Association of Immunologists, vol.179, no.3, 1913-1925.

  24. Szempruch, Anthony J., Sykes, Steven E., Kieft, R., Dennison, L., Becker, Allison C., Gartrell, A., Martin, William J., Nakayasu, Ernesto S., Almeida, Igor C., Hajduk, Stephen L., Harrington, John M.. Extracellular Vesicles from Trypanosoma brucei Mediate Virulence Factor Transfer and Cause Host Anemia. Cell, vol.164, no.1, 246-257.

  25. Hosseini-Beheshti, Elham, Pham, Steven, Adomat, Hans, Li, Na, Tomlinson Guns, Emma S.. Exosomes as Biomarker Enriched Microvesicles: Characterization of Exosomal Proteins Derived from a Panel of Prostate Cell Lines with Distinct AR Phenotypes. Molecular & cellular proteomics : MCP, vol.11, no.10, 863-885.

  26. Costa-Silva, Bruno, Aiello, Nicole M., Ocean, Allyson J., Singh, Swarnima, Zhang, Haiying, Thakur, Basant Kumar, Becker, Annette, Hoshino, Ayuko, Mark, Milica Tešić, Molina, Henrik, Xiang, Jenny, Zhang, Tuo, Theilen, Till-Martin, García-Santos, Guillermo, Williams, Caitlin, Ararso, Yonathan, Huang, Yujie, Rodrigues, Gonçalo, Shen, Tang-Long, Labori, Knut Jørgen, Lothe, Inger Marie Bowitz, Kure, Elin H., Hernandez, Jonathan, Doussot, Alexandre, Ebbesen, Saya H., Grandgenett, Paul M., Hollingsworth, Michael A., Jain, Maneesh, Mallya, Kavita, Batra, Surinder K., Jarnagin, William R., Schwartz, Robert E., Matei, Irina, Peinado, Héctor, Stanger, Ben Z., Bromberg, Jacqueline, Lyden, David. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nature cell biology, vol.17, no.6, 816-826.

  27. Melo, Sonia A., Luecke, Linda B., Kahlert, Christoph, Fernandez, Agustin F., Gammon, Seth T., Kaye, Judith, LeBleu, Valerie S., Mittendorf, Elizabeth A., Weitz, Juergen, Rahbari, Nuh, Reissfelder, Christoph, Pilarsky, Christian, Fraga, Mario F., Piwnica-Worms, David, Kalluri, Raghu. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature, vol.523, no.7559, 177-182.

  28. Peinado, H챕ctor, Ale?kovi?, Ma큄a, Lavotshkin, Simon, Matei, Irina, Costa-Silva, Bruno, Moreno-Bueno, Gema, Hergueta-Redondo, Marta, Williams, Caitlin, Garc챠a-Santos, Guillermo, Ghajar, Cyrus M, Nitadori-Hoshino, Ayuko, Hoffman, Caitlin, Badal, Karen, Garcia, Benjamin A, Callahan, Margaret K, Yuan, Jianda, Martins, Vilma R, Skog, Johan, Kaplan, Rosandra N, Brady, Mary S, Wolchok, Jedd D, Chapman, Paul B, Kang, Yibin, Bromberg, Jacqueline, Lyden, David. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nature medicine, vol.18, no.6, 883-891.

  29. Hoshino, Ayuko, Costa-Silva, Bruno, Shen, Tang-Long, Rodrigues, Goncalo, Hashimoto, Ayako, Mark, Milica Tesic, Molina, Henrik, Kohsaka, Shinji, Di Giannatale, Angela, Ceder, Sophia, Singh, Swarnima, Williams, Caitlin, Soplop, Nadine, Uryu, Kunihiro, Pharmer, Lindsay, King, Tari, Bojmar, Linda, Davies, Alexander E., Ararso, Yonathan, Zhang, Tuo, Zhang, Haiying, Hernandez, Jonathan, Weiss, Joshua M., Dumont-Cole, Vanessa D., Kramer, Kimberly, Wexler, Leonard H., Narendran, Aru, Schwartz, Gary K., Healey, John H., Sandstrom, Per, Labori, Knut Jørgen, Kure, Elin H., Grandgenett, Paul M., Hollingsworth, Michael A., de Sousa, Maria, Kaur, Sukhwinder, Jain, Maneesh, Mallya, Kavita, Batra, Surinder K., Jarnagin, William R., Brady, Mary S., Fodstad, Oystein, Muller, Volkmar, Pantel, Klaus, Minn, Andy J., Bissell, Mina J., Garcia, Benjamin A., Kang, Yibin, Rajasekhar, Vinagolu K., Ghajar, Cyrus M., Matei, Irina, Peinado, Hector, Bromberg, Jac. Tumour exosome integrins determine organotropic metastasis. Nature, vol.527, no.7578, 329-335.

  30. Hiemstra, Thomas F., Charles, Philip D., Gracia, Tannia, Hester, Svenja S., Gatto, Laurent, Al-Lamki, Rafia, Floto, R. Andres, Su, Ya, Skepper, Jeremy N., Lilley, Kathryn S., Karet Frankl, Fiona E.. Human Urinary Exosomes as Innate Immune Effectors. Journal of the American Society of Nephrology : JASN, vol.25, no.9, 2017-2027.

  31. Anderson, Johnathon D., Johansson, Henrik J., Graham, Calvin S., Vesterlund, Mattias, Pham, Missy T., Bramlett, Charles S., Montgomery, Elizabeth N., Mellema, Matt S., Bardini, Renee L., Contreras, Zelenia, Hoon, Madeline, Bauer, Gerhard, Fink, Kyle D., Fury, Brian, Hendrix, Kyle J., Chedin, Frederic, EL‐Andaloussi, Samir, Hwang, Billie, Mulligan, Michael S., Lehtiö, Janne, Nolta, Jan A.. Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via Nuclear Factor‐KappaB Signaling. Stem cells : (Dayton, Ohio), vol.34, no.3, 601-613.

  32. Phinney, Donald G., Di Giuseppe, Michelangelo, Njah, Joel, Sala, Ernest, Shiva, Sruti, St Croix, Claudette M., Stolz, Donna B., Watkins, Simon C., Di, Y. Peter, Leikauf, George D., Kolls, Jay, Riches, David W. H., Deiuliis, Giuseppe, Kaminski, Naftali, Boregowda, Siddaraju V., McKenna, David H., Ortiz, Luis A.. Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs. Nature communications, vol.6, 8472-.

  33. Li, Jianhua, Liu, Kuancheng, Liu, Yang, Xu, Yan, Zhang, Fei, Yang, Huijuan, Liu, Jiangxia, Pan, Tingting, Chen, Jieliang, Wu, Min, Zhou, Xiaohui, Yuan, Zhenghong. Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity. Nature immunology, vol.14, no.8, 793-803.

  34. Chang, Cheng, Zhang, Jiyang, Han, Mingfei, Ma, Jie, Zhang, Wei, Wu, Songfeng, Liu, Kehui, Xie, Hongwei, He, Fuchu, Zhu, Yunping. SILVER: an efficient tool for stable isotope labeling LC-MS data quantitative analysis with quality control methods. Bioinformatics, vol.30, no.4, 586-587.

  35. Huang, Da Wei, Sherman, Brad T, Lempicki, Richard A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nature protocols, vol.4, no.1, 44-57.

  36. Yu, Guangchuang, Wang, Li-Gen, Han, Yanyan, He, Qing-Yu. clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters. OMICS : a journal of integrative biology, vol.16, no.5, 284-287.

  37. Takahashi, Y., Nishikawa, M., Shinotsuka, H., Matsui, Y., Ohara, S., Imai, T., Takakura, Y.. Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection. Journal of biotechnology, vol.165, no.2, 77-84.

  38. Sun, Yulin, Zheng, Weiwei, Guo, Zhengguang, Ju, Qiang, Zhu, Lin, Gao, Jiajia, Zhou, Lanping, Liu, Fang, Xu, Yang, Zhan, Qimin, Zhou, Zhixiang, Sun, Wei, Zhao, Xiaohang. A novel TP53 pathway influences the HGS -mediated exosome formation in colorectal cancer. Scientific reports, vol.6, 28083-.

  39. Hubert, Audrey, Subra, Caroline, Jenabian, Mohammad-Ali, Tremblay Labrecque, Pierre-François, Tremblay, Cécile, Laffont, Benoit, Provost, Patrick, Routy, Jean-Pierre, Gilbert, Caroline. Elevated Abundance, Size, and MicroRNA Content of Plasma Extracellular Vesicles in Viremic HIV-1+ Patients: Correlations With Known Markers of Disease Progression. Journal of acquired immune deficiency syndromes : JAIDS, vol.70, no.3, 219-227.

  40. Keerthikumar, S., Chisanga, D., Ariyaratne, D., Al Saffar, H., Anand, S., Zhao, K., Samuel, M., Pathan, M., Jois, M., Chilamkurti, N., Gangoda, L., Mathivanan, S.. ExoCarta: A Web-Based Compendium of Exosomal Cargo. Journal of molecular biology, vol.428, no.4, 688-692.

  41. Covert, Markus W., Leung, Thomas H., Gaston, Jahlionais E., Baltimore, David. Achieving Stability of Lipopolysaccharide-Induced NF-&kgr;B Activation. Science, vol.309, no.5742, 1854-1857.

  42. Park, Beom Seok, Song, Dong Hyun, Kim, Ho Min, Choi, Byong-Seok, Lee, Hayyoung, Lee, Jie-Oh. The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex. Nature, vol.458, no.7242, 1191-1195.

  43. Hayden, Matthew S., Ghosh, Sankar. Shared Principles in NF-κB Signaling. Cell, vol.132, no.3, 344-362.

  44. Vallabhapurapu, Sivakumar, Karin, Michael. Regulation and Function of NF- κ B Transcription Factors in the Immune System. Annual review of immunology, vol.27, 693-733.

  45. Shenoy, Avinash R., Wellington, David A., Kumar, Pradeep, Kassa, Hilina, Booth, Carmen J., Cresswell, Peter, MacMicking, John D.. GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals. Science, vol.336, no.6080, 481-485.

  46. Vestal, Deborah J.. Review:The Guanylate-Binding Proteins (GBPs): Proinflammatory Cytokine-Induced Members of the Dynamin Superfamily with Unique GTPase Activity. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, vol.25, no.8, 435-443.

  47. Pei, Rongjuan, Qin, Bo, Zhang, Xiaoyong, Zhu, Wandi, Kemper, Thekla, Ma, Zhiyong, Trippler, Martin, Schlaak, Joerg, Chen, Xinwen, Lu, Mengji. Interferon-Induced Proteins with Tetratricopeptide Repeats 1 and 2 Are Cellular Factors That Limit Hepatitis B Virus Replication. Journal of Innate Immunity, vol.6, no.2, 182-191.

  48. O'Shea, John J., Schwartz, Daniella M., Villarino, Alejandro V., Gadina, Massimo, McInnes, Iain B., Laurence, Arian. The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention*. Annual review of medicine, vol.66, 311-328.

  49. Zheng, Qingliang, Hou, Jin, Zhou, Ye, Yang, Yingyun, Cao, Xuetao. Type I IFN–Inducible Downregulation of MicroRNA-27a Feedback Inhibits Antiviral Innate Response by Upregulating Siglec1/TRIM27. The journal of immunology : official journal of the American Association of Immunologists, vol.196, no.3, 1317-1326.

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