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[해외논문] Isoquercitrin protects against pulmonary hypertension via inhibiting PASMCs proliferation

Clinical and experimental pharmacology & physiology, v.44 no.3, 2017년, pp.362 - 370  

Zhang, Yongtao (Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, China) ,  Cui, Yuqian (Centre for Reproductive Medicine, Qilu Hospital of Shandong University, Jinan, China) ,  Deng, Wei (Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China) ,  Wang, Hao (Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, China) ,  Qin, Weidong (Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, China) ,  Huang, Chengmin (Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Educatio) ,  Li, Chen ,  Zhang, Jianning ,  Guo, Yuan ,  Wu, Dawei ,  Guo, Haipeng

Abstract AI-Helper 아이콘AI-Helper

SummaryPulmonary vascular remodelling is a common feature among the heterogeneous disorders that cause pulmonary arterial hypertension (PAH), and pulmonary arterial smooth muscle cells (PASMCs) proliferation impact the long‐term prognosis of the patient. Isoquercitrin (IQC) is a flavonoid with...

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참고문헌 (37)

  1. Rabinovitch, Marlene. Molecular pathogenesis of pulmonary arterial hypertension. The Journal of clinical investigation, vol.122, no.12, 4306-4313.

  2. Crosswhite, Patrick, Sun, Zhongjie. Molecular Mechanisms of Pulmonary Arterial Remodeling. Molecular medicine, vol.20, no.1, 191-201.

  3. Morrell, Nicholas W., Adnot, Serge, Archer, Stephen L., Dupuis, Jocelyn, Lloyd Jones, Peter, MacLean, Margaret R., McMurtry, Ivan F., Stenmark, Kurt R., Thistlethwaite, Patricia A., Weissmann, Norbert, Yuan, Jason X.-J., Weir, E. Kenneth. Cellular and Molecular Basis of Pulmonary Arterial Hypertension. Journal of the American College of Cardiology, vol.54, no.1, S20-S31.

  4. Falcetti, Emilia, Hall, Susan M., Phillips, Peter G., Patel, Jigisha, Morrell, Nicholas W., Haworth, Sheila G., Clapp, Lucie H.. Smooth Muscle Proliferation and Role of the Prostacyclin (IP) Receptor in Idiopathic Pulmonary Arterial Hypertension. American journal of respiratory and critical care medicine : an official journal of the American Thoracic Society, medical section of the American Lung Association, vol.182, no.9, 1161-1170.

  5. Ikeda, Tetsuya, Nakamura, Kazufumi, Akagi, Satoshi, Kusano, Kengo Fukushima, Matsubara, Hiromi, Fujio, Hideki, Ogawa, Aiko, Miura, Aya, Miura, Daiji, Oto, Takahiro, Yamanaka, Ryutaro, Otsuka, Fumio, Date, Hiroshi, Ohe, Tohru, Ito, Hiroshi. Inhibitory Effects of Simvastatin on Platelet-derived Growth Factor Signaling in Pulmonary Artery Smooth Muscle Cells From Patients With Idiopathic Pulmonary Arterial Hypertension. Journal of cardiovascular pharmacology, vol.55, no.1, 39-48.

  6. Perros, Frédéric, Montani, David, Dorfmüller, Peter, Durand-Gasselin, Ingrid, Tcherakian, Colas, Le Pavec, Jérôme, Mazmanian, Michel, Fadel, Elie, Mussot, Sacha, Mercier, Olaf, Hervé, Philippe, Emilie, Dominique, Eddahibi, Saadia, Simonneau, Gérald, Souza, Rogério, Humbert, Marc. Platelet-derived Growth Factor Expression and Function in Idiopathic Pulmonary Arterial Hypertension. American journal of respiratory and critical care medicine : an official journal of the American Thoracic Society, medical section of the American Lung Association, vol.178, no.1, 81-88.

  7. Schermuly, Ralph Theo, Dony, Eva, Ghofrani, Hossein Ardeschir, Pullamsetti, Soni, Savai, Rajkumar, Roth, Markus, Sydykov, Akylbek, Lai, Ying Ju, Weissmann, Norbert, Seeger, Werner, Grimminger, Friedrich. Reversal of experimental pulmonary hypertension by PDGF inhibition.. The Journal of clinical investigation, vol.115, no.10, 2811-2821.

  8. Valentova, K., Vrba, J., Bancirova, M., Ulrichova, J., Kren, V.. Isoquercitrin: Pharmacology, toxicology, and metabolism. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, vol.68, 267-282.

  9. Yang, Jun, Liu, Rui Hai. Synergistic Effect of Apple Extracts and Quercetin 3-β-D-Glucoside Combination on Antiproliferative Activity in MCF-7 Human Breast Cancer Cells in Vitro. Journal of agricultural and food chemistry, vol.57, no.18, 8581-8586.

  10. Paulo, Alexandra, Martins, Sofia, Branco, Pedro, Dias, Teresa, Borges, Carlos, Rodrigues, Ana Isabel, do Céu Costa, Maria, Teixeira, Adriano, Mota-Filipe, Hélder. The opposing effects of the flavonoids isoquercitrin and Sissotrin, isolated from Pterospartum tridentatum, on oral glucose tolerance in rats. Phytotherapy research : PTR, vol.22, no.4, 539-543.

  11. Rogerio, A. P., Kanashiro, A., Fontanari, C., da Silva, E. V. G., Lucisano-Valim, Y. M., Soares, E. G., Faccioli, L. H.. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflammation research : official journal of the European Histamine Research Society ... [et al.], vol.56, no.10, 402-408.

  12. Amado, Nathália G., Cerqueira, Débora M., Menezes, Fabio S., Mendes da Silva, Joaquim Fernando, Neto, Vivaldo Moura, Abreu, Jose G.. Isoquercitrin isolated from Hyptis fasciculata reduces glioblastoma cell proliferation and changes &bgr;-catenin cellular localization. Anti-cancer drugs, vol.20, no.7, 543-552.

  13. Lee, Sanghyun, Park, Hee-Seung, Notsu, Yohko, Ban, Hyun Seung, Kim, Yong Pil, Ishihara, Kenji, Hirasawa, Noriyasu, Jung, Sang Hoon, Lee, Yeon Sil, Lim, Soon Sung, Park, Eun-Hee, Shin, Kuk Hyun, Seyama, Toshio, Hong, JangJa, Ohuchi, Kazuo. Effects of hyperin, isoquercitrin and quercetin on lipopolysaccharide-induced nitrite production in rat peritoneal macrophages. Phytotherapy research : PTR, vol.22, no.11, 1552-1556.

  14. EMURA, Kazuhiro, YOKOMIZO, Atsushi, TOYOSHI, Tohru, MORIWAKI, Masamitsu. Effect of Enzymatically Modified Isoquercitrin in Spontaneously Hypertensive Rats. Journal of nutritional science and vitaminology, vol.53, no.1, 68-74.

  15. Gasparotto Junior, A., Gasparotto, F.M., Lourenco, E.L.B., Crestani, S., Stefanello, M.E.A., Salvador, M.J., da Silva-Santos, J.E., Marques, M.C.A., Kassuya, C.A.L.. Antihypertensive Effects of Isoquercitrin and Extracts from Tropaeolum majus L: Evidence for the Inhibition of Angiotensin Converting Enzyme. Journal of ethnopharmacology, vol.134, no.2, 363-372.

  16. Motoyama, K., Koyama, H., Moriwaki, M., Emura, K., Okuyama, S., Sato, E., Inoue, M., Shioi, A., Nishizawa, Y.. Atheroprotective and plaque-stabilizing effects of enzymatically modified isoquercitrin in atherogenic apoE-deficient mice. Nutrition, vol.25, no.4, 421-427.

  17. Casimiro, Mathew C, Velasco-Velázquez, Marco, Aguirre-Alvarado, Charmina, Pestell, Richard G. Overview of cyclins D1 function in cancer and the CDK inhibitor landscape: past and present. Expert opinion on investigational drugs, vol.23, no.3, 295-304.

  18. Chen, Bernadette, Calvert, Andrea E., Cui, Hongmei, Nelin, Leif D.. Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase. American journal of physiology. Lung cellular and molecular physiology, vol.297, no.6, L1151-L1159.

  19. Amado, Nathália G., Predes, Danilo, Fonseca, Barbara F., Cerqueira, Débora M., Reis, Alice H., Dudenhoeffer, Ana C., Borges, Helena L., Mendes, Fábio A., Abreu, Jose G.. Isoquercitrin Suppresses Colon Cancer Cell Growth in Vitro by Targeting the Wnt/β-Catenin Signaling Pathway. The Journal of biological chemistry, vol.289, no.51, 35456-35467.

  20. HUANG, GUIHONG, TANG, BO, TANG, KUN, DONG, XIAOMIN, DENG, JUNGANG, LIAO, LUQIN, LIAO, ZENGZHEN, YANG, HUA, HE, SONGQING. Isoquercitrin inhibits the progression of liver cancer in vivo and in vitro via the MAPK signalling pathway. Oncology reports, vol.31, no.5, 2377-2384.

  21. Bertoli, Cosetta, Skotheim, Jan M., de Bruin, Robertus A. M.. Control of cell cycle transcription during G1 and S phases. Nature reviews. Molecular cell biology, vol.14, no.8, 518-528.

  22. Hotchkiss, Adam, Robinson, Jessica, MacLean, Jessica, Feridooni, Tiam, Wafa, Karim, Pasumarthi, Kishore B.S.. Role of D-type cyclins in heart development and disease. Canadian journal of physiology and pharmacology, vol.90, no.9, 1197-1207.

  23. Tanner, Felix C., Boehm, Manfred, Akyürek, Levent M., San, Hong, Yang, Zhi-Yong, Tashiro, Jun, Nabel, Gary J., Nabel, Elizabeth G.. Differential Effects of the Cyclin-Dependent Kinase Inhibitors p27 Kip1 , p21 Cip1 , and p16 Ink4 on Vascular Smooth Muscle Cell Proliferation. Circulation, vol.101, no.17, 2022-2025.

  24. Barst, Robyn J. PDGF signaling in pulmonary arterial hypertension.. The Journal of clinical investigation, vol.115, no.10, 2691-2694.

  25. 10.4161/cc.7.12.6166 

  26. Kim, Tack-Joong, Yun, Yeo-Pyo. Antiproliferative activity of NQ304, a synthetic 1,4-naphthoquinone, is mediated via the suppressions of the PI3K/Akt and ERK1/2 signaling pathways in PDGF-BB-stimulated vascular smooth muscle cells. Vascular pharmacology, vol.46, no.1, 43-51.

  27. Tseng, Ai-Sun, Engel, Felix B., Keating, Mark T.. The GSK-3 Inhibitor BIO Promotes Proliferation in Mammalian Cardiomyocytes. Chemistry & biology, vol.13, no.9, 957-963.

  28. Sklepkiewicz, Piotr, Schermuly, Ralph Theo, Tian, Xia, Ghofrani, Hossein Ardeschir, Weissmann, Norbert, Sedding, Daniel, Kashour, Tarek, Seeger, Werner, Grimminger, Friedrich, Pullamsetti, Soni Savai. Glycogen Synthase Kinase 3beta Contributes to Proliferation of Arterial Smooth Muscle Cells in Pulmonary Hypertension. PloS one, vol.6, no.4, e18883-.

  29. Diehl, J. Alan, Cheng, Mangeng, Roussel, Martine F., Sherr, Charles J.. Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization. Genes & development, vol.12, no.22, 3499-3511.

  30. CHEN, FENG, CHEN, XIAOCHI, YANG, DEYONG, CHE, XIANGYU, WANG, JIANBO, LI, XIANCHENG, ZHANG, ZHIWEI, WANG, QIFEI, ZHENG, WEI, WANG, LINA, WANG, XUEJIAN, SONG, XISHUANG. Isoquercitrin inhibits bladder cancer progression in vivo and in vitro by regulating the PI3K/Akt and PKC signaling pathways. Oncology reports, vol.36, no.1, 165-172.

  31. Zhan, Yumei, Kim, Shokei, Izumi, Yasukatsu, Izumiya, Yasuhiro, Nakao, Takafumi, Miyazaki, Hitoshi, Iwao, Hiroshi. Role of JNK, p38, and ERK in Platelet-Derived Growth Factor-Induced Vascular Proliferation, Migration, and Gene Expression. Arteriosclerosis, thrombosis, and vascular biology, vol.23, no.5, 795-801.

  32. Jung, S.M., Park, S.S., Kim, W.J., Moon, S.K.. Ras/ERK1 pathway regulation of p27KIP1-mediated G1-phase cell-cycle arrest in cordycepin-induced inhibition of the proliferation of vascular smooth muscle cells. European journal of pharmacology, vol.681, no.1, 15-22.

  33. CHEN, QUAN, LI, PING, LI, PING, XU, YONG, LI, YANG, TANG, BO. Isoquercitrin inhibits the progression of pancreatic cancer in vivo and in vitro by regulating opioid receptors and the mitogen-activated protein kinase signalling pathway. Oncology reports, vol.33, no.2, 840-848.

  34. Xu, Dachun, Guo, Haipeng, Xu, Xin, Lu, Zhongbing, Fassett, John, Hu, Xinli, Xu, Yawei, Tang, Qizhu, Hu, Dayi, Somani, Arif, Geurts, Aron M., Ostertag, Eric, Bache, Robert J., Weir, E. Kenneth, Chen, Yingjie. Exacerbated Pulmonary Arterial Hypertension and Right Ventricular Hypertrophy in Animals With Loss of Function of Extracellular Superoxide Dismutase. Hypertension, vol.58, no.2, 303-309.

  35. Chen, Yingjie, Guo, Haipeng, Xu, Dachun, Xu, Xin, Wang, Huan, Hu, Xinli, Lu, Zhongbing, Kwak, Dongmin, Xu, Yawei, Gunther, Roland, Huo, Yuqing, Weir, E. Kenneth. Left Ventricular Failure Produces Profound Lung Remodeling and Pulmonary Hypertension in Mice : Heart Failure Causes Severe Lung Disease. Hypertension, vol.59, no.6, 1170-1178.

  36. Guo, Haipeng, Zhang, Xin, Cui, Yuqian, Zhou, Heng, Xu, Dachun, Shan, Tichao, Zhang, Fan, Guo, Yuan, Chen, Yuguo, Wu, Dawei. Taxifolin protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload. Toxicology and applied pharmacology, vol.287, no.2, 168-177.

  37. Guo, H., Zhang, X., Cui, Y., Deng, W., Xu, D., Han, H., Wang, H., Chen, Y., Li, Y., Wu, D.. Isorhynchophylline protects against pulmonary arterial hypertension and suppresses PASMCs proliferation. Biochemical and biophysical research communications, vol.450, no.1, 729-734.

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