[논문]The role of scheduled second TACE in early-stage hepatocellular carcinoma with complete response to initial TACE

Kim, Jung Hee; Sinn, Dong Hyun; Shin, Sung Wook; Cho, Sung Ki; Kang, Wonseok; Gwak, Geum-Youn; Paik, Yong-Han; Lee, Joon Hyeok; Koh, Kwang Cheol; Paik, Seung Woon; Choi, Moon Seok

doi:10.3350/cmh.2016.0058

The role of scheduled second TACE in early-stage hepatocellular carcinoma with complete response to initial TACE 원문보기

Clinical and molecular hepatology, v.23 no.1, 2017년, pp.42 - 50

Kim, Jung Hee (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea) , Sinn, Dong Hyun (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea) , Shin, Sung Wook (Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea) , Cho, Sung Ki (Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea) , Kang, Wonseok (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea) , Gwak, Geum-Youn (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea) , Paik, Yong-Han (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea) , Lee, Joon Hyeok (Department of Medicine, Samsung Medical Center, Sungkyunkwan Univer) , Koh, Kwang Cheol , Paik, Seung Woon , Choi, Moon Seok

Abstract ▼ AI-Helper

Background/AimsWe investigated the outcomes of early-stage hepatocellular carcinoma (HCC) patients who showed a complete response (CR) to initial transarterial chemoembolization (TACE), with a focus on the role of scheduled TACE repetition.MethodsA total of 178 patients with early-stage HCC who were initially treated with TACE and showed a CR based on the modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria on one month follow-up computed tomography (CT) were analyzed. Among them, 90 patients underwent scheduled repetition of TACE in the absence of viable tumor on CT.ResultsDuring a median follow-up period of 4.6 years (range: 0.4-8.8 years), mortality was observed in 71 patients (39.9%). The overall recurrence-free and local recurrence-free survival rates at 1 year were 44.4% and 56.2%. In the multivariable model, scheduled repetition of TACE was an independent factor associated with survival (hazard ratio [95% confidence interval]: 0.56 [0.34-0.93], P=0.025). When stratified using Barcelona clinic liver cancer (BCLC) stage, scheduled repetition of TACE was associated with a favorable survival rate in BCLC stage A patients, but not in BCLC 0 patients.ConclusionsScheduled repetition of TACE was associated with better survival for early-stage HCC patients showing a CR after initial TACE, especially in BCLC stage A patients.

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참고문헌 (17)

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The role of scheduled second TACE in early-stage hepatocellular carcinoma with complete response to initial TACE 원문보기

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