[논문]Depigmenting Effect of Resveratrol Is Dependent on FOXO3a Activation without SIRT1 Activation

Kwon, Soon-Hyo; Choi, Hye-Ryung; Kang, Youn-A; Park, Kyoung-Chan

doi:10.3390/ijms18061213

Depigmenting Effect of Resveratrol Is Dependent on FOXO3a Activation without SIRT1 Activation 원문보기

International journal of molecular sciences, v.18 no.6, 2017년, pp.1213 -

Kwon, Soon-Hyo , Choi, Hye-Ryung , Kang, Youn-A , Park, Kyoung-Chan

Abstract ▼ AI-Helper

Resveratrol exhibits not only anti-melanogenic property by inhibiting microphthalmia-associated transcription factor (MITF), but also anti-aging property by activating sirtuin-1 (SIRT1). In this study, the relationship between depigmenting effect of resveratrol and SIRT1/forkhead box O (FOXO) 3a activation and was investigated. Resveratrol suppressed melanogenesis by the downregulation of MITF and tyrosinase via ERK pathway. Results showed that the expression of both SIRT1 and FOXO3a were increased. It is reported that SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress. However in our study, FOXO3a activation appeared earlier than that of SIRT1. Furthermore, the effect of resveratrol on the levels of MITF and tyrosinase was suppressed when melanocytes were pre-treated with SP600125 (JNK inhibitor). However, pre-treatment with SIRT1 inhibitor (EX527, or sirtinol) did not affect the levels of MITF and tyrosinase. Therefore, resveratrol inhibits melanogenesis through the activation of FOXO3a but not by the activation of SIRT1. Although SIRT1 activation by resveratrol is a well-known mechanism of resveratrol-induced antiaging effects, our study showed that not SIRT1 but FOXO3a activation is involved in depigmenting effects of resveratrol.

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참고문헌 (37)

1. Okazaki M. Yoshimura K. Uchida G. Harii K. Correlation between age and the secretions of melanocyte-stimulating cytokines in cultured keratinocytes and fibroblasts Br. J. Dermatol. 2005 153 Suppl. 2 23 29 10.1111/j.1365-2133.2005.06966.x 16280018

상세보기
2. Kovacs D. Cardinali G. Aspite N. Cota C. Luzi F. Bellei B. Briganti S. Amantea A. Torrisi M.R. Picardo M. Role of fibroblast-derived growth factors in regulating hyperpigmentation of solar lentigo Br. J. Dermatol. 2010 163 1020 1027 10.1111/j.1365-2133.2010.09946.x 20662835

상세보기
3. Luger T.A. Schwarz T. Evidence for an epidermal cytokine network J. Investig. Dermatol. 1990 95 Suppl. 6 100S 104S 10.1111/1523-1747.ep12874944 2258624

상세보기
4. Imokawa G. Miyagishi M. Yada Y. Endothelin-1 as a new melanogen: Coordinated expression of its gene and the tyrosinase gene in UVB-exposed human epidermis J. Investig. Dermatol. 1995 105 32 37 10.1111/1523-1747.ep12312500 7615973

상세보기
5. Schauer E. Trautinger F. Kock A. Schwarz A. Bhardwaj R. Simon M. Ansel J.C. Schwarz T. Luger T.A. Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes J. Clin. Investig. 1994 93 2258 2262 10.1172/JCI117224 8182158

상세보기
6. Smit N. Le Poole I. van den Wijngaard R. Tigges A. Westerhof W. Das P. Expression of different immunological markers by cultured human melanocytes Arch. Dermatol. Res. 1993 285 356 365 10.1007/BF00371837 8215585

상세보기
7. Tomita Y. Iwamoto M. Masuda T. Tagami H. Stimulatory effect of prostaglandin E2 on the configuration of normal human melanocytes in vitro J. Investig. Dermatol. 1987 89 299 301 10.1111/1523-1747.ep12471536 3305717

상세보기
8. Shin J. Kim J.H. Kim E.K. Repeated exposure of human fibroblasts to UVR induces secretion of stem cell factor and senescence J. Eur. Acad. Dermatol. Venereol. 2012 26 1577 1580 10.1111/j.1468-3083.2011.04223.x 21929554

상세보기
9. Torres-Alvarez B. Mesa-Garza I.G. Castanedo-Cazares J.P. Fuentes-Ahumada C. Oros-Ovalle C. Navarrete-Solis J. Moncada B. Histochemical and immunohistochemical study in melasma: Evidence of damage in the basal membrane Am. J. Dermatopathol. 2011 33 291 295 10.1097/DAD.0b013e3181ef2d45 21317614

상세보기
10. Howitz K.T. Bitterman K.J. Cohen H.Y. Lamming D.W. Lavu S. Wood J.G. Zipkin R.E. Chung P. Kisielewski A. Zhang L.L. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan Nature 2003 425 191 196 10.1038/nature01960 12939617

상세보기
11. Lin C.B. Babiarz L. Liebel F. Roydon Price E. Kizoulis M. Gendimenico G.J. Fisher D.E. Seiberg M. Modulation of microphthalmia-associated transcription factor gene expression alters skin pigmentation J. Investig. Dermatol. 2002 119 1330 1340 10.1046/j.1523-1747.2002.19615.x 12485436

상세보기
12. Bertolotto C. Busca R. Abbe P. Bille K. Aberdam E. Ortonne J.P. Ballotti R. Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: Pivotal role of M boxes (GTCATGTGCT) and of microphthalmia Mol. Cell. Biol. 1998 18 694 702 10.1128/MCB.18.2.694 9447965

상세보기
13. Bentley N.J. Eisen T. Goding C.R. Melanocyte-specific expression of the human tyrosinase promoter: Activation by the microphthalmia gene product and role of the initiator Mol. Cell. Biol. 1994 14 7996 8006 10.1128/MCB.14.12.7996 7969139

상세보기
14. Newton R.A. Cook A.L. Roberts D.W. Leonard J.H. Sturm R.A. Post-transcriptional regulation of melanin biosynthetic enzymes by cAMP and resveratrol in human melanocytes J. Investig. Dermatol. 2007 127 2216 2227 10.1038/sj.jid.5700840 17460731

상세보기
15. Kim Y.M. Yun J. Lee C.K. Lee H. Min K.R. Kim Y. Oxyresveratrol and hydroxystilbene compounds. Inhibitory effect on tyrosinase and mechanism of action J. Biol. Chem. 2002 277 16340 16344 10.1074/jbc.M200678200 11864987

상세보기
16. Kairisalo M. Bonomo A. Hyrskyluoto A. Mudo G. Belluardo N. Korhonen L. Lindholm D. Resveratrol reduces oxidative stress and cell death and increases mitochondrial antioxidants and XIAP in PC6.3-cells Neurosci. Lett. 2011 488 263 266 10.1016/j.neulet.2010.11.042 21094207

상세보기
17. Kim S.Y. Park K.C. Kwon S.B. Kim D.S. Hypopigmentary effects of 4-n-butylresorcinol and resveratrol in combination Pharmazie 2012 67 542 546 22822544

상세보기
18. Nakae J. Biggs W.H. 3rd Kitamura T. Cavenee W.K. Wright C.V. Arden K.C. Accili D. Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1 Nat. Genet. 2002 32 245 253 10.1038/ng890 12219087

상세보기
19. Holzenberger M. Dupont J. Ducos B. Leneuve P. Geloen A. Even P.C. Cervera P. Le Bouc Y. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice Nature 2003 421 182 187 10.1038/nature01298 12483226

상세보기
20. Hu M.C. Lee D.F. Xia W. Golfman L.S. Ou-Yang F. Yang J.Y. Zou Y. Bao S. Hanada N. Saso H. IκB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a Cell 2004 117 225 237 10.1016/S0092-8674(04)00302-2 15084260

상세보기
21. Paik J.H. Kollipara R. Chu G. Ji H. Xiao Y. Ding Z. Miao L. Tothova Z. Horner J.W. Carrasco D.R. FOXOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis Cell 2007 128 309 323 10.1016/j.cell.2006.12.029 17254969

상세보기
22. Luo J. Nikolaev A.Y. Imai S. Chen D. Su F. Shiloh A. Guarente L. Gu W. Negative control of p53 by Sir2αpromotes cell survival under stress Cell 2001 107 137 148 10.1016/S0092-8674(01)00524-4 11672522

상세보기
23. Vaziri H. Dessain S.K. Ng Eaton E. Imai S.I. Frye R.A. Pandita T.K. Guarente L. Weinberg R.A. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase Cell 2001 107 149 159 10.1016/S0092-8674(01)00527-X 11672523

상세보기
24. Huang H. Tindall D.J. Dynamic FoxO transcription factors J. Cell Sci. 2007 120 2479 2487 10.1242/jcs.001222 17646672

상세보기
25. Hori Y.S. Kuno A. Hosoda R. Horio Y. Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress PLoS ONE 2013 8 e73875 10.1371/journal.pone.0073875 24040102

상세보기
26. Camins A. Sureda F.X. Junyent F. Verdaguer E. Folch J. Pelegri C. Vilaplana J. Beas-Zarate C. Pallas M. Sirtuin activators: Designing molecules to extend life span Biochim. Biophys. Acta 2010 1799 740 749 10.1016/j.bbagrm.2010.06.005 20601277

상세보기
27. Tang B.L. Sirt1 and the Mitochondria Mol. Cells 2016 39 87 95 26831453

원문보기 상세보기
28. Horio Y. Hayashi T. Kuno A. Kunimoto R. Cellular and molecular effects of sirtuins in health and disease Clin. Sci. 2011 121 191 203 10.1042/CS20100587 21599635

상세보기
29. Ido Y. Duranton A. Lan F. Weikel K.A. Breton L. Ruderman N.B. Resveratrol prevents oxidative stress-induced senescence and proliferative dysfunction by activating the AMPK-FOXO3 cascade in cultured primary human keratinocytes PLoS ONE 2015 10 e0115341 10.1371/journal.pone.0115341 25647160

상세보기
30. Gunschmann C. Stachelscheid H. Akyuz M.D. Schmitz A. Missero C. Bruning J.C. Niessen C.M. Insulin/IGF-1 controls epidermal morphogenesis via regulation of FOXO-mediated p63 inhibition Dev. Cell 2013 26 176 187 10.1016/j.devcel.2013.05.017 23906066

상세보기
31. Kim J. Choi H. Cho E.G. Lee T.R. FOXO3a is an antimelanogenic factor that mediates antioxidant-induced depigmentation J. Investig. Dermatol. 2014 134 1378 1388 10.1038/jid.2013.510 24284420

상세보기
32. Ozel Turkcu U. Solak Tekin N. Gokdogan Edgunlu T. Karakas Celik S. Oner S. The association of FOXO3a gene polymorphisms with serum FOXO3a levels and oxidative stress markers in vitiligo patients Gene 2014 536 129 134 10.1016/j.gene.2013.11.055 24333267

상세보기
33. Eisinger M. Marko O. Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin Proc. Natl. Acad. Sci. USA 1982 79 2018 2022 10.1073/pnas.79.6.2018 6952249

상세보기
34. Medrano E.E. Nordlund J.J. Successful culture of adult human melanocytes obtained from normal and vitiligo donors J. Investig. Dermatol. 1990 95 441 445 1698887
35. Choi H.R. Kang Y.A. Lee H.S. Park K.C. Disulfanyl peptide decreases melanin synthesis via receptor-mediated ERK activation and the subsequent downregulation of MITF and tyrosinase Int. J. Cosmet. Sci. 2016 38 279 285 10.1111/ics.12291 26518989

상세보기
36. Busca R. Bertolotto C. Ortonne J.P. Ballotti R. Inhibition of the phosphatidylinositol 3-kinase/p70(S6)-kinase pathway induces B16 melanoma cell differentiation J. Biol. Chem. 1996 271 31824 31830 10.1074/jbc.271.50.31824 8943224

상세보기
37. Ko H.J. Kim H.J. Kim S.Y. Yun H.Y. Baek K.J. Kwon N.S. Wan Kyun W. Choi H.R. Park K.C. Kim D.S. Hypopigmentary effects of ethyl P -methoxycinnamate isolated from Kaempferia galanga Phytother. Res. 2014 28 274 279 10.1002/ptr.4995 23610003

상세보기

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Depigmenting Effect of Resveratrol Is Dependent on FOXO3a Activation without SIRT1 Activation 원문보기

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Depigmenting Effect of Resveratrol Is Dependent on FOXO3a Activation without SIRT1 Activation 원문보기

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참고문헌 (37)

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