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Scientific reports, v.7, 2017년, pp.8585 -
Lataniotis, Lazaros (King’s British Heart Foundation Centre, King’s College London, London, UK) , Albrecht, Andreas (Middlesex University, School of Science and Technology, London, UK) , Kok, Fatma O. (University of Massachusetts Medical School, Department of Molecular, Cell, and Cancer Biology, Worcester, USA) , Monfries, Clinton A. L. (King’s College London, Randall Division, London, UK) , Benedetti, Lorena (King’s College London, Division of Cancer Studies, London, UK) , Lawson, Nathan D. (University of Massachusetts Medical School, Department of Molecular, Cell, and Cancer Biology, Worcester, USA) , Hughes, Simon M. (King’s College London, Randall Division, London, UK) , Steinhofel, Kathleen (King’s College London, Informatics Department, London, UK) , Mayr, Manuel (King’s British Heart Foundation Centre, King’s College London, London, UK) , Zampetaki, Anna (King’s British Heart Foundation Centre, King’s College London, London, UK)
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MicroRNAs (miRNAs) are important regulators of diverse physiological and pathophysiological processes. MiRNA families and clusters are two key features in miRNA biology. Here we explore the use of CRISPR/Cas9 as a powerful tool to delineate the function and regulation of miRNA families and clusters....
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