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A ruthenium-based 5-fluorouracil complex with enhanced cytotoxicity and apoptosis induction action in HCT116 cells 원문보기

Scientific reports, v.8, 2018년, pp.288 - 288  

Silva, Valdenizia Rodrigues (Gonç) ,  Corrêa, Rodrigo S. (alo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ) ,  Santos, Luciano de Souza (Department of Chemistry, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil) ,  Soares, Milena Botelho Pereira (Gonç) ,  Batista, Alzir Azevedo (alo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ) ,  Bezerra, Daniel Pereira (Gonç)

Abstract AI-Helper 아이콘AI-Helper

Combination of multifunctionalities into one compound is a rational strategy in medicinal chemical design, and have often been used with metallodrug-based compounds. In the present study, we synthesized a novel ruthenium-based 5-fluorouracil complex [Ru(5-FU)(PPh3)2(bipy)]PF6 (PPh3 = t...

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