[논문]Serum persistent organic pollutants levels and stroke risk

Lim, Jung-eun; Lee, Sunju; Lee, Sunmi; Jee, Sun Ha

doi:10.1016/j.envpol.2017.12.031

[해외논문] Serum persistent organic pollutants levels and stroke risk

Environmental pollution, v.233, 2018년, pp.855 - 861

Lim, Jung-eun (Institute for Health Promotion & Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University) , Lee, Sunju (Institute for Health Promotion & Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University) , Lee, Sunmi (Health Insurance Policy Research Institute, National Health Insurance Service) , Jee, Sun Ha (Institute for Health Promotion & Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University)

Abstract ▼ AI-Helper

Abstract Knowledge of environmental risk factors for stroke and their role are limited. We performed a case-cohort study to evaluate the association between serum persistent organic pollutants (POPs) level and stroke risk. 526 subcohort members and 111 stroke incidence cases were identified from the Korean Cancer Prevention Study-II. Serum levels of POPs were measured using gas chromatography/high-resolution mass spectrometry. The hazard ratios (HRs) for stroke (ischemic, hemorrhagic, and all stroke types) were estimated using the weighted Cox regression model. Age, sex, body mass index, smoking status, physical activity, family history of cardiovascular disease, and hypertension were adjusted in the weighted Cox regression model. After adjusting for potential confounding factors, increased risk for stroke was observed among participants with serum concentration of p,p'-DDE in the highest tertile compared to those in the lowest tertile (HR = 4.10, 95% CI: 1.58, 10.59). A similar association was estimated for PCB118 (HR = 2.33, 95% CI: 1.04, 5.22), PCB156 (HR = 3.42, 95% CI: 1.42, 8.23), and PCB138 (HR = 3.80, 95% CI: 1.48, 9.76). For TEQ, stroke was three times as likely to occur among subjects with TEQ in the highest tertile compared to those in the lowest tertile (HR = 3.12, 95% CI: 1.27, 7.65). PCBs were positively associated with ischemic stroke, but not with hemorrhagic stroke. Elevated serum POPs levels were associated with an increased risk of stroke, especially ischemic stroke. Highlights This study is the first prospective study of the association between serum POPs level and stroke risk. Serum levels of 32 PCBs and 19 OCPs were measured. Several POPs levels were associated with an increased risk of developing stroke. Increased stroke risk was observed among participants with TEQ in the highest tertile compared to those in the lowest tertile. PCBs were positively associated with ischemic stroke but not with hemorrhagic stroke. Graphical abstract [DISPLAY OMISSION]

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