[논문]Polydopamine-coated nanocomposites of Angelica gigas Nakai extract and their therapeutic potential for triple-negative breast cancer cells

Nam, Suyeong; Lee, Song Yi; Kim, Jung-Jin; Kang, Wie-Soo; Yoon, In-Soo; Cho, Hyun-Jong

doi:10.1016/j.colsurfb.2018.02.014

Polydopamine-coated nanocomposites of Angelica gigas Nakai extract and their therapeutic potential for triple-negative breast cancer cells

Colloids and surfaces. B, Biointerfaces, v.165, 2018년, pp.74 - 82

Nam, Suyeong (College of Pharmacy, Kangwon National University) , Lee, Song Yi (College of Pharmacy, Kangwon National University) , Kim, Jung-Jin (College of Pharmacy, Kangwon National University) , Kang, Wie-Soo (School of Bioscience and Biotechnology, Kangwon National University) , Yoon, In-Soo (College of Pharmacy, Pusan National University) , Cho, Hyun-Jong (College of Pharmacy, Kangwon National University)

Abstract ▼ AI-Helper

Abstract Polydopamine (PD)-coated nanocomposites (NCs) based on the ethanol extract of Angelica gigas Nakai (AGN EtOH ext) were fabricated and evaluated for breast cancer therapy. AGN NCs were prepared using a modified emulsification-solvent evaporation method and were further incubated in dopamine solution (at pH 8.6) to be covered with the PD layer. PD-AGN NCs with a 213-nm mean diameter, narrow size distribution, and negative zeta potential values were fabricated in this study. Less negative (close to zero) zeta potential value of PD-AGN NCs than that of AGN NCs implied the existence of the PD layer in the outer surface of NCs. The PD layer in PD-AGN NCs was also identified by X-ray photoelectron spectroscopy (XPS) and ultraviolet (UV)/visible absorption analyses. The sustained release of decursin (D) and decursinol angelate (DA), as major active pharmacological components of AGN, was observed in both AGN NCs and PD-AGN NCs. Enhanced cellular binding property of PD-AGN NCs, compared to AGN NCs, in MDA-MB-231 (human breast adenocarcinoma; triple-negative breast cancer) cells was observed. Improved anticancer activities of PD-AGN NCs compared with those of AGN EtOH ext and AGN NCs were also shown in MDA-MB-231 cells. The developed PD-AGN NCs may be used as remarkable platform nanocarriers for efficient breast cancer therapy. Highlights Nanocomposites (NCs) composed of Angelica gigas Nakai (AGN) extract were fabricated. Polydopamine (PD) layer was coated onto the outer surface of AGN NCs. Cellular adhesiveness of PD-AGN NCs was higher than AGN NCs in breast cancer cells. Improved anticancer activities were shown in PD-AGN NCs group than AGN NCs group. Graphical abstract [DISPLAY OMISSION]

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Polydopamine-coated nanocomposites of Angelica gigas Nakai extract and their therapeutic potential for triple-negative breast cancer cells

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Polydopamine-coated nanocomposites of Angelica gigas Nakai extract and their therapeutic potential for triple-negative breast cancer cells

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