$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Fms-like tyrosine kinase-3 ligand increases resistance to burn wound infection through effects on plasmacytoid dendritic cells 원문보기

BMC immunology, v.18 no.1, 2017년, pp.9 -   

Bae, Leon (Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, USA) ,  Bohannon, Julia K. (Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, USA) ,  Cui, Weihua (Department of Anesthesiology, University of Texas Medical Branch and Shriners Hospitals for Children, 301 University Boulevard, Galveston, TX 77555-0877 USA) ,  Vinish, Monika (Department of Anesthesiology, University of Texas Medical Branch and Shriners Hospitals for Children, 301 University Boulevard, Galveston, TX 77555-0877 USA) ,  Toliver-Kinsky, Tracy (Department of Anesthesiology, University of Texas Medical Branch and Shriners Hospitals for Children, 301 University Boulevard, Galveston, TX 77555-0877 USA)

Abstract AI-Helper 아이콘AI-Helper

BackgroundPatients experiencing large thermal injuries are susceptible to opportunistic infections that can delay recovery and lead to sepsis. Dendritic cells (DC) are important for the detection of pathogens and activation of the innate and acquired immune responses. DCs are significantly decreased...

주제어

참고문헌 (23)

  1. 1. Williams FN Herndon DN Hawkins HK Lee JO Cox RA Kulp GA Finnerty CC Chinkes DL Jeschke MG The leading causes of death after burn injury in a single pediatric burn center Crit Care 2009 13 6 R183 10.1186/cc8170 19919684 

  2. 2. Brom J Köller M Schlüter B Müller-Lange P Ulrich Steinau H König W Expression of the adhesion molecule CD11b and polymerization of actin by polymorphonuclear granulocytes of patients endangered by sepsis Burns 1995 21 6 427 431 10.1016/0305-4179(95)00011-Y 8554683 

  3. 3. Butler KL Ambravaneswaran V Agrawal N Bilodeau M Toner M Tompkins RG Fagan S Irimia D Burn injury reduces neutrophil directional migration speed in microfluidic devices PLoS One 2010 5 7 e11921 10.1371/journal.pone.0011921 20689600 

  4. 4. Bender BS Winchurch RA Thupari JN Proust JJ Adler WH Munster AM Depressed natural killer cell function in thermally injured adults: successful in vivo and in vitro immunomodulation and the role of endotoxin Clin Exp Immunol 1988 71 1 120 125 3258200 

  5. 5. Noel JG Osterburg A Wang Q Guo X Byrum D Schwemberger S Goetzman H Caldwell CC Ogle CK Thermal injury elevates the inflammatory monocyte subpopulation in multiple compartments Shock 2007 28 6 684 693 17607156 

  6. 6. Toliver-Kinsky TE Varma TK Lin CY Herndon DN Sherwood ER Interferon-gamma production is suppressed in thermally injured mice: decreased production of regulatory cytokines and corresponding receptors Shock 2002 18 4 322 330 10.1097/00024382-200210000-00006 12392275 

  7. 7. D’Arpa N Accardo-Palumbo A Amato G D’Amelio L Pileri D Cataldo V Mogavero R Lombardo C Napoli B Conte F Circulating dendritic cells following burn Burns 2009 35 4 513 518 10.1016/j.burns.2008.05.027 19269101 

  8. 8. Toliver-Kinsky TE Cui W Murphey ED Lin C Sherwood ER Enhancement of dendritic cell production by fms-like tyrosine kinase-3 ligand increases the resistance of mice to a burn wound infection J Immunol 2005 174 1 404 410 10.4049/jimmunol.174.1.404 15611264 

  9. 9. Maraskovsky E Brasel K Teepe M Roux ER Lyman SD Shortman K McKenna HJ Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified J Exp Med 1996 184 5 1953 1962 10.1084/jem.184.5.1953 8920882 

  10. 10. Maraskovsky E Daro E Roux E Teepe M Maliszewski CR Hoek J Caron D Lebsack ME McKenna HJ In vivo generation of human dendritic cell subsets by Flt3 ligand Blood 2000 96 3 878 884 10910900 

  11. 11. Pulendran B Lingappa J Kennedy MK Smith J Teepe M Rudensky A Maliszewski CR Maraskovsky E Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice J Immunol 1997 159 5 2222 2231 9278310 

  12. 12. Pulendran B Banchereau J Burkeholder S Kraus E Guinet E Chalouni C Caron D Maliszewski C Davoust J Fay J Palucka K Flt3-ligand and granulocyte colony-stimulating factor mobilize distinct human dendritic cell subsets in vivo J Immunol 2000 165 1 566 572 10.4049/jimmunol.165.1.566 10861097 

  13. 13. Bohannon J Cui W Sherwood E Toliver-Kinsky T Dendritic cell modification of neutrophil responses to infection after burn injury J Immunol 2010 185 5 2847 2853 10.4049/jimmunol.0903619 20679533 

  14. 14. Ito T Amakawa R Inaba M Hori T Ota M Nakamura K Takebayashi M Miyaji M Yoshimura T Inaba K Fukuhara S Plasmacytoid dendritic cells regulate Th cell responses through OX40 ligand and type I IFNs J Immunol 2004 172 7 4253 4259 10.4049/jimmunol.172.7.4253 15034038 

  15. 15. Cella M Jarrossay D Facchetti F Alebardi O Nakajima H Lanzavecchia A Colonna M Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon Nat Med 1999 5 8 919 923 10.1038/11360 10426316 

  16. 16. Villadangos JA Young L Antigen-presentation properties of plasmacytoid dendritic cells Immunity 2008 29 352 361 10.1016/j.immuni.2008.09.002 18799143 

  17. 17. Yoneyama H Matsuno K Toda E Nishiwaki T Matsuo N Nakano A Narumi S Lu B Gerard C Ishikawa S Matsushima K Plasmacytoid DCs help lymph node DCs to induce anti-HSV CTLs J Exp Med 2005 202 3 425 435 10.1084/jem.20041961 16061729 

  18. 18. Kuwajima S Sato T Ishida K Tada H Tezuka H Ohteki T Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation Nat Immunol 2006 7 7 740 746 10.1038/ni1348 16715101 

  19. 19. Bohannon J Cui W Cox R Przkora R Sherwood E Toliver-Kinsky T Prophylactic treatment with fms-like tyrosine kinase-3 ligand after burn injury enhances global immune responses to infection J Immunol 2008 180 5 3038 3048 10.4049/jimmunol.180.5.3038 18292526 

  20. 20. Toliver-Kinsky TE Lin CY Herndon DN Sherwood ER Stimulation of hematopoiesis by the Fms-like tyrosine kinase 3 ligand restores bacterial induction of Th1 cytokines in thermally injured mice Infect Immun 2003 71 6 3058 3067 10.1128/IAI.71.6.3058-3067.2003 12761083 

  21. 21. Patil NK, Bohannon JK, Luan L, Guo Y, Fensterheim B, Hernandez A, Wang J, Sherwood ER. FLT3 Ligand Treatment Attenuates T Cell Dysfunction and Improves Survival in A Murine Model of Burn Wound Sepsis. Shock. (2016) Jul 21. [Epub ahead of print]. 

  22. 22. Vinish M Cui W Stafford E Bae L Hawkins H Cox R Toliver-Kinsky T Dendritic cells modulate burn wound healing by enhancing early proliferation Wound Repair Regen 2016 24 1 6 13 10.1111/wrr.12388 26609910 

  23. 23. Finnerty CC Jeschke MG Herndon DN Gamelli R Gibran N Klein M Silver G Arnoldo B Remick D Tompkins RG Investigators of the inflammation and the host response glue grant. Temporal cytokine profiles in severely burned patients: a comparison of adults and children Mol Med 2008 14 9–10 553 560 18548133 

관련 콘텐츠

원문 보기

원문 URL 링크

*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로