[논문]Analysis of Prognostic Factors in Malignant External Otitis

Lee, Sang Kuk; Lee, Se A; Seon, Sang Woo; Jung, Jae Hyun; Lee, Jong Dae; Choi, Jae Young; Kim, Bo Gyung

doi:10.21053/ceo.2016.00612

[국내논문] Analysis of Prognostic Factors in Malignant External Otitis 원문보기

Clinical and experimental otorhinolaryngology, v.10 no.3, 2017년, pp.228 - 235

Lee, Sang Kuk (Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon, Korea) , Lee, Se A (Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon, Korea) , Seon, Sang Woo (Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon, Korea) , Jung, Jae Hyun (Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon, Korea) , Lee, Jong Dae (Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon, Korea) , Choi, Jae Young (Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea) , Kim, Bo Gyung (Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon, Korea)

Abstract ▼ AI-Helper

Objectives Malignant external otitis (MEO) is a potentially fatal infection of the external auditory canal, temporal bone, and skull base. Despite treatment with modern antibiotics, MEO can lead to skull base osteomyelitis. Until now, there have been few studies on the prognostic factors of MEO.Methods We performed a retrospective study to identify prognostic factors of MEO, and a meta-analysis of other articles investigating MEO. On the basis of disease progression the 28 patients in our study were divided into ‘controlled’ and ‘uncontrolled’ groups, consisting of 12 and 16 patients, respectively. We identified three categories of prognostic factors: those related to patient, disease, and treatment. We compared these prognostic factors between the controlled and uncontrolled groups.ResultsIn our study, the duration of diabetes mellitus (DM), presence of inflammatory markers (C-reactive protein and erythrocyte sedimentation rate), and computed tomography or magnetic resonance imaging findings influenced the prognosis of MEO. In contrast, prognosis was unrelated to age, gender, mean glucose level, hemoglobin A1c level, pathogen, comorbidity, or cranial nerve involvement. No factor related to treatment modality was correlated with prognosis, such as surgery, steroid therapy, or interval to the first appropriate treatment. Cranial nerve involvement has been proven to be associated with disease progression, but the relationship between cranial nerve involvement and the prognosis of MEO remains controversial. As a part of this study, we conducted a meta-analysis of cranial nerve involvement as a prognostic factor of MEO. We found that cranial nerve involvement has a statistically significant influence on the prognosis of MEO.Conclusion We found that glycemic control in diabetes mellitus, cranial nerve involvement, and the extent of disease determined from various imaging modalities influence the prognosis of MEO. We suggest that significant prognostic factors should be monitored to determine the prognosis of patients with MEO.

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참고문헌 (25)

1 Rubin J Yu VL Malignant external otitis: insights into pathogenesis, clinical manifestations, diagnosis, and therapy Am J Med 1988 9 85 3 391 8 3046354

상세보기
2 Chandler JR Malignant external otitis and facial paralysis Otolaryngol Clin North Am 1974 6 7 2 375 83 4209507
3 Nadol JB Jr Histopathology of Pseudomonas osteomyelitis of the temporal bone starting as malignant external otitis Am J Otolaryngol 1980 11 1 5 359 71 7457757

상세보기
4 Rowlands RG Lekakis GK Hinton AE Masked pseudomonal skull base osteomyelitis presenting with a bilateral Xth cranial nerve palsy J Laryngol Otol 2002 7 116 7 556 8 12238681

상세보기
5 Mani N Sudhoff H Rajagopal S Moffat D Axon PR Cranial nerve involvement in malignant external otitis: implications for clinical outcome Laryngoscope 2007 5 117 5 907 10 17473694

상세보기
6 Soudry E Joshua BZ Sulkes J Nageris BI Characteristics and prognosis of malignant external otitis with facial paralysis Arch Otolaryngol Head Neck Surg 2007 10 133 10 1002 4 17938323

상세보기
7 Cohen D Friedman P The diagnostic criteria of malignant external otitis J Laryngol Otol 1987 3 101 3 216 21 3106547

상세보기
8 Ali T Meade K Anari S ElBadawey MR Zammit-Maempel I Malignant otitis externa: case series J Laryngol Otol 2010 8 124 8 846 51 20388240

상세보기
9 Lee S Hooper R Fuller A Turlakow A Cousins V Nouraei R Otogenic cranial base osteomyelitis: a proposed prognosis-based system for disease classification Otol Neurotol 2008 8 29 5 666 72 18520626

상세보기
10 Franco-Vidal V Blanchet H Bebear C Dutronc H Darrouzet V Necrotizing external otitis: a report of 46 cases Otol Neurotol 2007 9 28 6 771 3 17721365

상세보기
11 Chen CN Chen YS Yeh TH Hsu CJ Tseng FY Outcomes of malignant external otitis: survival vs mortality Acta Otolaryngol 2010 130 1 89 94 19466617

상세보기
12 Chandler JR Malignant external otitis Laryngoscope 1968 8 78 8 1257 94 4970362

상세보기
13 Joshua BZ Sulkes J Raveh E Bishara J Nageris BI Predicting outcome of malignant external otitis Otol Neurotol 2008 4 29 3 339 43 18317396

상세보기
14 Geerlings SE Hoepelman AI Immune dysfunction in patients with diabetes mellitus (DM) FEMS Immunol Med Microbiol 1999 12 26 3-4 259 65 10575137
15 O’Sullivan TJ Dickson RI Blokmanis A Roberts FJ Kaan K The pathogenesis, differential diagnosis, and treatment of malignant otitis externa J Otolaryngol 1978 8 7 4 297 303 691096

상세보기
16 Lucente FE Parisier SC Som PM Arnold LM Malignant external otitis: a dangerous misnomer? Otolaryngol Head Neck Surg 1982 Mar-Apr 90 2 266 9 6810275
17 Lucente FE Parisier SC Som PM Complications of the treatment of malignant external otitis Laryngoscope 1983 3 93 3 279 81 6834949

상세보기
18 Bernheim J Sade J Histopathology of the soft parts in 50 patients with malignant external otitis J Laryngol Otol 1989 4 103 4 366 8 2715689

상세보기
19 Sudhoff H Rajagopal S Mani N Moumoulidis I Axon PR Moffat D Usefulness of CT scans in malignant external otitis: effective tool for the diagnosis, but of limited value in predicting outcome Eur Arch Otorhinolaryngol 2008 1 265 1 53 6 17680261

상세보기
20 Kondziella D Skagervik I Malignant external otitis with extensive cranial neuropathy but no facial paralysis J Neurol 2007 9 254 9 1298 9 17325817

상세보기
21 Stokkel MP Takes RP van Eck-Smit BL Baatenburg de Jong RJ The value of quantitative gallium-67 single-photon emission tomography in the clinical management of malignant external otitis Eur J Nucl Med 1997 11 24 11 1429 32 9371879

상세보기
22 Okpala NC Siraj QH Nilssen E Pringle M Radiological and radionuclide investigation of malignant otitis externa J Laryngol Otol 2005 1 119 1 71 5 15807974

상세보기
23 Stevens SM Lambert PR Mastoidectomy: surgical techniques Flint PW Haughey BH Lund VJ Niparko JK Robbins KT Thomas JR Cummings otolaryngology: head and neck surgery 6th ed Philadelphia (PA) Elsevier Saunders 2015 2188 99
24 Brant JA Ruckenstein MJ Infections of the external ear Flint PW Haughey BH Lund VJ Niparko JK Robbins KT Thomas JR Cummings otolaryngology: head and neck surgery 6th ed Philadelphia (PA) Elsevier Saunders 2015 2115 22
25 Walvekar RR Culicchia F Nuss DW Surgery of the anterior and middle cranial base Flint PW Haughey BH Lund VJ Niparko JK Robbins KT Thomas JR Cummings otolaryngology: head and neck surgery 6th ed Philadelphia (PA) Elsevier Saunders 2015 2671 700

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[국내논문] Analysis of Prognostic Factors in Malignant External Otitis 원문보기

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