[논문]Bioactive α-Pyrone Derivatives from the Endolichenic Fungus Dothideomycetes sp. EL003334

Kim, Gil Soo; Ko, Wonmin; Kim, Jong Won; Jeong, Min-Hye; Ko, Sung-Kyun; Hur, Jae-Seoun; Oh, Hyuncheol; Jang, Jae-Hyuk; Ahn, Jong Seog

doi:10.1021/acs.jnatprod.7b01022

Bioactive α-Pyrone Derivatives from the Endolichenic Fungus Dothideomycetes sp. EL003334

Journal of natural products, v.81 no.4, 2018년, pp.1084 - 1088

Kim, Gil Soo (Anticancer Agent Research Center , Korea Research Institute of Bioscience and Biotechnology (KRIBB) , Cheongju 28116 , Korea) , Ko, Wonmin (College of Pharmacy , Wonkwang University , Iksan 54538 , Korea) , Kim, Jong Won (Anticancer Agent Research Center , Korea Research Institute of Bioscience and Biotechnology (KRIBB) , Cheongju 28116 , Korea) , Jeong, Min-Hye (Korean Lichen Research Institute , Sunchon National University , Suncheon 57922 , Korea) , Ko, Sung-Kyun (Anticancer Agent Research Center , Korea Research Institute of Bioscience and Biotechnology (KRIBB) , Cheongju 28116 , Korea) , Hur, Jae-Seoun (Korean Lichen Research Institute , Sunchon National University , Suncheon 57922 , Korea) , Oh, Hyuncheol (College of Pharmacy , Wonkwang University , Iksan 54538 , Korea) , Jang, Jae-Hyuk , Ahn, Jong Seog

Abstract ▼ AI-Helper

Two new α-pyrones, dothideopyrones E (1) and F (2), were isolated from a culture of the endolichenic fungus Dothideomycetes sp. EL003334. Their structures were elucidated by spectroscopic data analysis. Their absolute configurations were established by the modified Mosher’s method. Compound 2 inhibited nitric oxide (NO) production with IC50 values of 15.0 ± 2.8 μM in lipopolysaccharide (LPS)-induced BV2 cells. Compound 2 diminished the protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Additionally, 2 decreased the mRNA expression levels of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6.[FIG OMISSION]

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Bioactive α-Pyrone Derivatives from the Endolichenic Fungus Dothideomycetes sp. EL003334

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Bioactive α-Pyrone Derivatives from the Endolichenic Fungus Dothideomycetes sp. EL003334

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