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NTIS 바로가기Scientific reports, v.8, 2018년, pp.11926 -
Dogra, Nilambra (National Centre for Human Genome Studies and Research, Panjab University, Sector-14, Chandigarh, 160014 India) , Kumar, Ashok (National Centre for Human Genome Studies and Research, Panjab University, Sector-14, Chandigarh, 160014 India) , Mukhopadhyay, Tapas (National Centre for Human Genome Studies and Research, Panjab University, Sector-14, Chandigarh, 160014 India)
Drugs that are already clinically approved or experimentally tested for conditions other than cancer, but are found to possess previously unrecognized cytotoxicity towards malignant cells, may serve as fitting anti-cancer candidates. Methyl N-(6-phenylsulfanyl-1H benzimidazol-2-yl) carbamate [Fenben...
1. Jordan MA Wilson L Microtubules as a target for anticancer drugs Nat Rev Cancer 2004 4 253 265 10.1038/nrc1317 15057285
2. Hamel E Antimitotic natural products and their interactions with tubulin Med Res Rev 1996 16 207 231 10.1002/(SICI)1098-1128(199603)16:2 3.0.CO;2-4 8656780
3. Hamel E Interactions of antimitotic peptides and depsipeptides with tubulin Biopolymers 2002 66 142 160 10.1002/bip.10255 12385035
4. Jackson JR Patrick DR Dar MM Huang PS Targeted anti-mitotic therapies: can we improve on tubulin agents? Nat Rev Cancer 2007 7 107 117 10.1038/nrc2049 17251917
5. Mukhtar E Adhami VM Mukhtar H Targeting microtubules by natural agents for cancer therapy Mol Cancer Ther 2014 13 275 284 10.1158/1535-7163.MCT-13-0791 24435445
7. Villar D Cray C Zaias J Altman NH Biologic effects of fenbendazole in rats and mice: a review J Am Assoc Lab Anim Sci 2007 46 8 15 17994667
8. Muser RK Paul JW Safety of fenbendazole use in cattle Mod Vet Pract 1984 65 371 374 6738510
9. Schwartz RD Donoghue AR Baggs RB Clark T Partington C Evaluation of the safety of fenbendazole in cats Am J Vet Res 2000 61 330 332 10.2460/ajvr.2000.61.330 10714528
10. Hayes RH Oehme FW Leipold H Safety of fenbendazole in swine Am J Vet Res 1983 44 1112 1116 6870016
11. Hayes RH Oehme FW Leipold H Toxicity investigation of fenbendazole, an anthelmintic of swine Am J Vet Res 1983 44 1108 1111 6870015
12. Hinz E [Fenbendazole therapy of experimental larval echinococcosis. I. The effect of fenbendazole on worm burden and protoscolex development of Echinococcus multilocularis (author’s transl)] Zentralbl Bakteriol Orig A 1978 240 542 548 696062
13. Sams-Dodd F Target-based drug discovery: is something wrong? Drug Discov Today 2005 10 139 147 10.1016/S1359-6446(04)03316-1 15718163
14. Pao W Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain PLoS Med 2005 2 e73 10.1371/journal.pmed.0020073 15737014
15. Bean J MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib Proc Natl Acad Sci USA 2007 104 20932 20937 10.1073/pnas.0710370104 18093943
16. Laclette JP Guerra G Zetina C Inhibition of tubulin polymerization by mebendazole Biochem Biophys Res Commun 1980 92 417 423 10.1016/0006-291X(80)90349-6 7356473
17. Gull K Dawson PJ Davis C Byard EH Microtubules as target organelles for benzimidazole anthelmintic chemotherapy Biochem Soc Trans 1987 15 59 60 10.1042/bst0150059 3556740
18. Lacey E Watson TR Structure-activity relationships of benzimidazole carbamates as inhibitors of mammalian tubulin, in vitro Biochem Pharmacol 1985 34 1073 1077 10.1016/0006-2952(85)90611-2 3985991
19. Barbuti AM Chen ZS Paclitaxel Through the Ages of Anticancer Therapy: Exploring Its Role in Chemoresistance and Radiation Therapy Cancers (Basel) 2015 7 2360 2371 10.3390/cancers7040897 26633515
20. Yusuf RZ Duan Z Lamendola DE Penson RT Seiden MV Paclitaxel resistance: molecular mechanisms and pharmacologic manipulation Curr Cancer Drug Targets 2003 3 1 19 10.2174/1568009033333754 12570657
21. Mozzetti S Class III beta-tubulin overexpression is a prominent mechanism of paclitaxel resistance in ovarian cancer patients Clin Cancer Res 2005 11 298 305 15671559
22. Dumontet C Jordan MA Microtubule-binding agents: a dynamic field of cancer therapeutics Nat Rev Drug Discov 2010 9 790 803 10.1038/nrd3253 20885410
23. Seve P Dumontet C Is class III beta-tubulin a predictive factor in patients receiving tubulin-binding agents? Lancet Oncol 2008 9 168 175 10.1016/S1470-2045(08)70029-9 18237851
24. Stengel C Class III beta-tubulin expression and in vitro resistance to microtubule targeting agents Br J Cancer 2010 102 316 324 10.1038/sj.bjc.6605489 20029418
25. Lu Y Chen J Xiao M Li W Miller DD An overview of tubulin inhibitors that interact with the colchicine binding site Pharm Res 2012 29 2943 2971 10.1007/s11095-012-0828-z 22814904
26. Wu X Wang Q Li W Recent Advances in Heterocyclic Tubulin Inhibitors Targeting the Colchicine Binding Site Anticancer Agents Med Chem 2016 16 1325 1338 10.2174/1871520616666160219161921 26899186
27. Zhou J Giannakakou P Targeting microtubules for cancer chemotherapy Curr Med Chem Anticancer Agents 2005 5 65 71 10.2174/1568011053352569 15720262
28. Teodori E Dei S Martelli C Scapecchi S Gualtieri F The functions and structure of ABC transporters: implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR) Curr Drug Targets 2006 7 893 909 10.2174/138945006777709520 16842220
29. Kartner N Riordan JR Ling V Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines Science 1983 221 1285 1288 10.1126/science.6137059 6137059
30. Gottesman MM Fojo T Bates SE Multidrug resistance in cancer: role of ATP-dependent transporters Nat Rev Cancer 2002 2 48 58 10.1038/nrc706 11902585
31. Ford JM Experimental reversal of P-glycoprotein-mediated multidrug resistance by pharmacological chemosensitisers Eur J Cancer 1996 32A 991 1001 10.1016/0959-8049(96)00047-0 8763340
32. van Zuylen L Nooter K Sparreboom A Verweij J Development of multidrug-resistance convertors: sense or nonsense? Invest New Drugs 2000 18 205 220 10.1023/A:1006487003814 10958589
33. Jouan, E. et al . Evaluation of P-Glycoprotein Inhibitory Potential Using a Rhodamine 123 Accumulation Assay. Pharmaceutics 8 , 10.3390/pharmaceutics8020012 (2016).
34. Clute P Pines J Temporal and spatial control of cyclin B1 destruction in metaphase Nat Cell Biol 1999 1 82 87 10.1038/10049 10559878
35. Dogra, N. & Mukhopadhyay, T. Impairment of the ubiquitin-proteasome pathway by methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate leads to a potent cytotoxic effect in tumor cells: a novel antiproliferative agent with a potential therapeutic implication. J Biol Chem 287 , 30625-30640, 10.1074/jbc.M111.324228.
36. Castedo M Cell death by mitotic catastrophe: a molecular definition Oncogene 2004 23 2825 2837 10.1038/sj.onc.1207528 15077146
37. Mansilla S Priebe W & Portugal, J. Mitotic catastrophe results in cell death by caspase-dependent and caspase-independent mechanisms Cell Cycle 2006 5 53 60 10.4161/cc.5.1.2267 16319532
38. Giustiniani J Tubulin acetylation favors Hsp90 recruitment to microtubules and stimulates the signaling function of the Hsp90 clients Akt/PKB and p53 Cell Signal 2009 21 529 539 10.1016/j.cellsig.2008.12.004 19136058
39. Giannakakou P Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics Proc Natl Acad Sci USA 2002 99 10855 10860 10.1073/pnas.132275599 12145320
40. Marchenko ND Wolff S Erster S Becker K Moll UM Monoubiquitylation promotes mitochondrial p53 translocation EMBO J 2007 26 923 934 10.1038/sj.emboj.7601560 17268548
41. Jasra N Sanyal SN Khera S Effect of thiabendazole and fenbendazole on glucose uptake and carbohydrate metabolism in Trichuris globulosa Vet Parasitol 1990 35 201 209 10.1016/0304-4017(90)90055-G 2343538
42. Selak MA Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase Cancer Cell 2005 7 77 85 10.1016/j.ccr.2004.11.022 15652751
43. Loffler M Becker C Wegerle E Schuster G Catalytic enzyme histochemistry and biochemical analysis of dihydroorotate dehydrogenase/oxidase and succinate dehydrogenase in mammalian tissues, cells and mitochondria Histochem Cell Biol 1996 105 119 128 10.1007/BF01696151 8852433
44. Chou TC Talalay P Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors Adv Enzyme Regul 1984 22 27 55 10.1016/0065-2571(84)90007-4 6382953
45. Shen L Cell death by bortezomib-induced mitotic catastrophe in natural killer lymphoma cells Mol Cancer Ther 2008 7 3807 3815 10.1158/1535-7163.MCT-08-0641 19074855
46. Aft RL Zhang FW Gius D Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death Br J Cancer 2002 87 805 812 10.1038/sj.bjc.6600547 12232767
47. Vander Heiden MG Cantley LC Thompson CB Understanding the Warburg effect: the metabolic requirements of cell proliferation Science 2009 324 1029 1033 10.1126/science.1160809 19460998
48. Mathupala SP Ko YH Pedersen PL Hexokinase-2 bound to mitochondria: cancer’s stygian link to the “Warburg Effect” and a pivotal target for effective therapy Semin Cancer Biol 2009 19 17 24 10.1016/j.semcancer.2008.11.006 19101634
49. Maldonado, E. N., Patnaik, J., Mullins, M. R. & Lemasters, J. J. Free tubulin modulates mitochondrial membrane potential in cancer cells. Cancer Res 70 , 10192-10201, 10.1158/0008-5472.CAN-10-2429.
50. Schwartzenberg-Bar-Yoseph F Armoni M Karnieli E The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression Cancer Res 2004 64 2627 2633 10.1158/0008-5472.CAN-03-0846 15059920
51. Fletcher LM Welsh GI Oatey PB Tavare JM Role for the microtubule cytoskeleton in GLUT4 vesicle trafficking and in the regulation of insulin-stimulated glucose uptake Biochem J 2000 352 Pt 2 267 276 10.1042/bj3520267 11085918
52. Mathupala SP Ko YH Pedersen PL Hexokinase II: cancer’s double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria Oncogene 2006 25 4777 4786 10.1038/sj.onc.1209603 16892090
53. Liu Y Proline oxidase functions as a mitochondrial tumor suppressor in human cancers Cancer Res 2009 69 6414 6422 10.1158/0008-5472.CAN-09-1223 19654292
54. Polyak K Xia Y Zweier JL Kinzler KW Vogelstein B A model for p53-induced apoptosis Nature 1997 389 300 305 10.1038/38525 9305847
55. Maddocks, O. D. & Vousden, K. H. Metabolic regulation by p53. J Mol Med (Berl) 89 , 237–245, 10.1007/s00109-011-0735-5.
56. Matoba S p53 regulates mitochondrial respiration Science 2006 312 1650 1653 10.1126/science.1126863 16728594
57. Kawauchi K Araki K Tobiume K Tanaka N p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation Nat Cell Biol 2008 10 611 618 10.1038/ncb1724 18391940
58. Li, T. et al . Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell 149 , 1269-1283, 10.1016/j.cell.2012.04.026.
59. Hu, W. et al . Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci USA 107 , 7455-7460, 10.1073/pnas.1001006107.
60. Legault J Microtubule disruption induced in vivo by alkylation of beta-tubulin by 1-aryl-3-(2-chloroethyl)ureas, a novel class of soft alkylating agents Cancer Res 2000 60 985 992 10706114
61. Beyer CF TTI-237: a novel microtubule-active compound with in vivo antitumor activity Cancer Res 2008 68 2292 2300 10.1158/0008-5472.CAN-07-1420 18381436
62. Bradford MM A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 1976 72 248 254 10.1016/0003-2697(76)90527-3 942051
63. Darrow, R. A. & Colowick, S. P. Vol. V (1962).
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