[논문]Anticancer Activity of Cynomorium coccineum

Sdiri, Mouna; Li, Xiangmin; Du, William W.; El-Bok, Safia; Xie, Yi-Zhen; Ben-Attia, Mossadok; Yang, Burton B.

doi:10.3390/cancers10100354

Anticancer Activity of Cynomorium coccineum 원문보기

Cancers, v.10 no.10, 2018년, pp.354 -

Sdiri, Mouna (Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada) , Li, Xiangmin (sdiri.mouna88@gmail.com (M.S.)) , Du, William W. (xiangmin227@163.com (X.L.)) , El-Bok, Safia (weidong.du@alum.utoronto.ca (W.W.D.)) , Xie, Yi-Zhen (Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada) , Ben-Attia, Mossadok (sdiri.mouna88@gmail.com (M.S.)) , Yang, Burton B. (xiangmin227@163.com (X.L.))

Abstract ▼ AI-Helper

The extensive applications of Cynomorium species and their rich bioactive secondary metabolites have inspired many pharmacological investigations. Previous research has been conducted to examine the biological activities and numerous interesting pharmaceutical activities have been reported. However, the antitumor activities of these species are unclear. To understand the potential anticancer activity, we screened Cynomorium coccineum and Cynomorium songaricum using three different extracts of each species. In this study, the selected extracts were evaluated for their ability to decrease survival rates of five different cancer cell lines. We compared the cytotoxicity of the three different extracts to the anticancer drug vinblastine and one of the most well-known medicinal mushrooms Amaurederma rude. We found that the water and alcohol extracts of C. coccineum at the very low concentrations possessed very high capacity in decreasing the cancer cells viability with a potential inhibition of tumorigenesis. Based on these primitive data, we subsequently tested the ethanol and the water extracts of C. coccineum, respectively in in vitro and in vivo assays. Cell cycle progression and induction of programmed cell death were investigated at both biological and molecular levels to understand the mechanism of the antitumor inhibitory action of the C. coccineum. The in vitro experiments showed that the treated cancer cells formed fewer and smaller colonies than the untreated cells. Cell cycle progression was inhibited, and the ethanol extract of C.coccineum at a low concentration induced accumulation of cells in the G1 phase. We also found that the C. coccineum’s extracts suppressed viability of two murine cancer cell lines. In the in vivo experiments, we injected mice with murine cancer cell line B16, followed by peritoneal injection of the water extract. The treatment prolonged mouse survival significantly. The tumors grew at a slower rate than the control. Down-regulation of c-myc expression appeared to be associated with these effects. Further investigation showed that treatment with C.coccineum induced the overexpression of the tumor suppressor Foxo3 and other molecules involved in inducing autophagy. These results showed that the C. coccineum extract exerts its antiproliferative activity through the induction of cell death pathway. Thus, the Cynomorium plants appear to be a promising source of new antineoplastic compounds.

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참고문헌 (37)

1. Liu T. Men Q. Wu G. Yu C. Huang Z. Liu X. Li W. Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells Oncotarget 2015 6 7992 8006 10.18632/oncotarget.3505 25797266

상세보기
2. Wong V.K. Chiu P. Chung S.S. Chow L.M. Zhao Y.Z. Yang B.B. Ko B.C. Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo Clin. Cancer Res. 2005 11 6002 6011 10.1158/1078-0432.CCR-05-0209 16115945

상세보기
3. Balachandran P. Govindarajan R. Cancer—An ayurvedic perspective Pharmacol. Res. 2005 51 19 30 10.1016/j.phrs.2004.04.010 15519531

상세보기
4. Zhang X. Gu C. Ahmad B. Huang L. Optimization of Extract Method for Cynomorium songaricum Rupr. by Response Surface Methodology J. Anal. Methods Chem. 2017 2017 6153802 10.1155/2017/6153802 29435384

상세보기
5. Liu Y. Li H. Wang X. Zhang G. Wang Y. Di D. Evaluation of the free radical scavenging activity of Cynomorium songaricum Rupr. by a novel DPPH-HPLC method J. Food Sci. 2011 76 C1245 1249 10.1111/j.1750-3841.2011.02392.x 22416684

상세보기
6. Lee J.S. Oh H.A. Kwon J.Y. Jeong M.H. Lee J.S. Kang D.W. Choi D. The Effects of Cynomorium songaricum on the Reproductive Activity in Male Golden Hamsters Dev. Reprod. 2013 17 37 43 10.12717/DR.2013.17.1.037 25949119

원문보기 상세보기
7. Yang W.M. Kim H.Y. Park S.Y. Kim H.M. Chang M.S. Park S.K. Cynomorium songaricum induces spermatogenesis with glial cell-derived neurotrophic factor (GDNF) enhancement in rat testes J. Ethnopharmacol. 2010 128 693 696 10.1016/j.jep.2010.02.020 20219665

상세보기
8. Ikram M. Dar M.S. Fakouhi T. Hypotensive agent from Cynomorium coccineum Pahlavi Med. J. 1978 9 167 181 683693

상세보기
9. Al-Qarawi A.A. Abdel-Rahman H.A. El-Badry A.A. Harraz F. Razig N.A. Abdel-Magied E.M. The effect of extracts of Cynomorium coccineum and Withania somnifera on gonadotrophins and ovarian follicles of immature Wistar rats Phytother. Res. 2000 14 288 290 10.1002/1099-1573(200006)14:4 3.0.CO;2-9 10861976

상세보기
10. Goncalves M.J. Piras A. Porcedda S. Marongiu B. Falconieri D. Cavaleiro C. Rescigno A. Rosa A. Salgueiro L. Antifungal activity of extracts from Cynomorium coccineum growing wild in Sardinia island (Italy) Nat. Prod. Res. 2015 29 2247 2250 10.1080/14786419.2014.1000892 25598435

상세보기
11. Wang X. Tao R. Yang J. Miao L. Wang Y. Munyangaju J.E. Wichai N. Wang H. Zhu Y. Liu E. Compounds from Cynomorium songaricum with Estrogenic and Androgenic Activities Suppress the Oestrogen/Androgen-Induced BPH Process Evid.-Based Complement. Altern. Med. 2017 2017 6438013 10.1155/2017/6438013 28588640

상세보기
12. Wang F. Liu Q. Wang W. Li X. Zhang J. A polysaccharide isolated from Cynomorium songaricum Rupr. protects PC12 cells against H2O2-induced injury Int. J. Biol. Macromol. 2016 87 222 228 10.1016/j.ijbiomac.2016.02.011 26853824

상세보기
13. Ma C. Nakamura N. Miyashiro H. Hattori M. Shimotohno K. Inhibitory effects of constituents from Cynomorium songaricum and related triterpene derivatives on HIV-1 protease Chem. Pharm. Bull. 1999 47 141 145 10.1248/cpb.47.141 10071849

상세보기
14. Liu M. Xiao G.G. Rong P. Zhang Z. Dong J. Zhao H. Li H. Li Y. Pan J. Liu H. Therapeutic effects of radix dipsaci, pyrola herb, and Cynomorium songaricum on bone metabolism of ovariectomized rats BMC Complement. Altern. Med. 2012 12 67 10.1186/1472-6882-12-67 22639966

상세보기
15. Yoo D.Y. Choi J.H. Kim W. Jung H.Y. Nam S.M. Kim J.W. Yoon Y.S. Yoo K.Y. Won M.H. Hwang I.K. Cynomorium songaricum extract enhances novel object recognition, cell proliferation and neuroblast differentiation in the mice via improving hippocampal environment BMC Complement. Altern. Med. 2014 14 5 10.1186/1472-6882-14-5 24393242

상세보기
16. Du W.W. Yang W. Liu E. Yang Z. Dhaliwal P. Yang B.B. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 Nucleic Acids Res. 2016 44 2846 2858 10.1093/nar/gkw027 26861625

상세보기
17. Yang W. Du W.W. Li X. Yee A.J. Yang B.B. Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis Oncogene 2016 35 3919 3931 10.1038/onc.2015.460 26657152

상세보기
18. Yang Q. Du W.W. Wu N. Yang W. Awan F.M. Fang L. Ma J. Li X. Zeng Y. Yang Z. A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation Cell Death Diff. 2017 24 1609 1620 10.1038/cdd.2017.86 28622299

상세보기
19. Du W.W. Yang W. Chen Y. Wu Z.K. Foster F.S. Yang Z. Li X. Yang B.B. Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses Eur. Heart J. 2017 38 1402 1412 10.1093/eurheartj/ehw001 26873092

상세보기
20. Zeng Y. Du W.W. Wu Y. Yang Z. Awan F.M. Li X. Yang W. Zhang C. Yang Q. Yee A. A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair Theranostics 2017 7 3842 3855 10.7150/thno.19764 29109781

상세보기
21. Yang Z.G. Awan F.M. Du W.W. Zeng Y. Lyu J. Wu D. Gupta S. Yang W. Yang B.B. The Circular RNA Interacts with STAT3, Increasing Its Nuclear Translocation and Wound Repair by Modulating Dnmt3a and miR-17 Function Mol. Ther. 2017 25 2062 2074 10.1016/j.ymthe.2017.05.022 28676341

상세보기
22. Du W.W. Fang L. Yang W. Wu N. Awan F.M. Yang Z. Yang B.B. Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity Cell Death Diff. 2017 24 357 370 10.1038/cdd.2016.133 27886165

상세보기
23. Fang L. Du W.W. Lyu J. Dong J. Zhang C. Yang W. He A. Kwok Y.S.S. Ma J. Wu N. Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1 Cell Death Diff. 2018 10.1038/s41418-018-0115-6 29795334

상세보기
24. Abd el-Rahman H.A. el-Badry A.A. Mahmoud O.M. Harraz F.A. The effect of the aqueous extract of Cynomorium coccineum on the epididymal sperm pattern of the rat Phytother. Res. 1999 13 248 250 10.1002/(SICI)1099-1573(199905)13:3 3.0.CO;2-D 10353171

상세보기
25. Garcia M.A. Nicholson E.H. Nickrent D.L. Extensive intraindividual variation in plastid rDNA sequences from the holoparasite Cynomorium coccineum (Cynomoriaceae) J. Mol. Evol. 2004 58 322 332 10.1007/s00239-003-2554-y 15045487

상세보기
26. Abdel-Magied E.M. Abdel-Rahman H.A. Harraz F.M. The effect of aqueous extracts of Cynomorium coccineum and Withania somnifera on testicular development in immature Wistar rats J. Ethnopharmacol. 2001 75 1 4 10.1016/S0378-8741(00)00348-2 11282435

상세보기
27. Rosa A. Rescigno A. Piras A. Atzeri A. Scano P. Porcedda S. Zucca P. Assunta Dessi M. Chemical composition and effect on intestinal Caco-2 cell viability and lipid profile of fixed oil from Cynomorium coccineum L. Food Chem. Toxicol. 2012 50 3799 3807 10.1016/j.fct.2012.07.003 22809475

상세보기
28. Rosa A. Nieddu M. Piras A. Atzeri A. Putzu D. Rescigno A. Maltese mushroom ( Cynomorium coccineum L.) as source of oil with potential anticancer activity Nutrients 2015 7 849 864 10.3390/nu7020849 25629557

상세보기
29. Zucca P. Rosa A. Tuberoso C.I. Piras A. Rinaldi A.C. Sanjust E. Dessi M.A. Rescigno A. Evaluation of antioxidant potential of “maltese mushroom” ( Cynomorium coccineum ) by means of multiple chemical and biological assays Nutrients 2013 5 149 161 10.3390/nu5010149 23344249

상세보기
30. Jiao C. Xie Y.Z. Yang X. Li H. Li X.M. Pan H.H. Cai M.H. Zhong H.M. Yang B.B. Anticancer activity of Amauroderma rude PLoS ONE 2013 8 e66504 10.1371/journal.pone.0066504 23840494

상세보기
31. Li X. Wu Q. Bu M. Hu L. Du W.W. Jiao C. Pan H. Sdiri M. Wu N. Xie Y. Ergosterol peroxide activates Foxo3-mediated cell death signaling by inhibiting AKT and c-Myc in human hepatocellular carcinoma cells Oncotarget 2016 7 33948 33959 10.18632/oncotarget.8608 27058618

상세보기
32. Wu Q.P. Xie Y.Z. Deng Z. Li X.M. Yang W. Jiao C.W. Fang L. Li S.Z. Pan H.H. Yee A.J. Ergosterol peroxide isolated from Ganoderma lucidum abolishes microRNA miR-378-mediated tumor cells on chemoresistance PLoS ONE 2012 7 e44579 10.1371/journal.pone.0044579 22952996

상세보기
33. Chen S. Li X. Yong T. Wang Z. Su J. Jiao C. Xie Y. Yang B.B. Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure-activity relationships Oncotarget 2017 8 10071 10084 10.18632/oncotarget.14336 28052025

상세보기
34. Pan H. Han Y. Huang J. Yu X. Jiao C. Yang X. Dhaliwal P. Xie Y. Yang B.B. Purification and identification of a polysaccharide from medicinal mushroom Amauroderma rude with immunomodulatory activity and inhibitory effect on tumor growth Oncotarget 2015 6 17777 17791 10.18632/oncotarget.4397 26219260

상세보기
35. Li X. Wu Q. Xie Y. Ding Y. Du W.W. Sdiri M. Yang B.B. Ergosterol purified from medicinal mushroom Amauroderma rude inhibits cancer growth in vitro and in vivo by up-regulating multiple tumor suppressors Oncotarget 2015 6 17832 17846 10.18632/oncotarget.4026 26098777

상세보기
36. Attia I.B. Zucca P. Marincola F.C. Piras A. Rosa A. Chaieb M. Rescigno A. Chemical Composition and Antioxidant Potential Differences between Cynomorium coccineum L. Growing in Italy and in Tunisia: Effect of Environmental Stress Diversity 2018 10 53 10.3390/d10030053

상세보기
37. Zucca P. Argiolas A. Nieddu M. Pintus M. Rosa A. Sanna F. Sollai F. Steri D. Rescigno A. Biological Activities and Nutraceutical Potentials of Water Extracts from Different Parts of Cynomorium coccineum L. (Maltese Mushroom) Pol. J. Food Nutr. Sci. 2016 66 179 188 10.1515/pjfns-2016-0006

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Anticancer Activity of Cynomorium coccineum 원문보기

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