[논문]Memory enhancing activity of extract of new citrus cultivar ‘Shinyegam’in mice

Kim, Sang Suk; Park, Ji Yong; Lee, Won Chang; Park, Chang-Yong; Ko, Bong-Hyon; Jeon, Yoon-A; Park, Kyung Jin; An, Hyun Joo; Kang, Seok Beom; Yun, Su Hyun; Choi, Young Hun; Lee, Young Jae

doi:10.11002/kjfp.2018.25.7.855

[국내논문] Memory enhancing activity of extract of new citrus cultivar ‘Shinyegam’in mice
마우스에서 국내 육성 신품종 ‘신예감’ 추출물의 기억력 증진 효과 원문보기

한국식품저장유통학회지 = Korean journal of food preservation, v.25 no.7, 2018년, pp.855 - 862

Kim, Sang Suk , Park, Ji Yong , Lee, Won Chang , Park, Chang-Yong , Ko, Bong-Hyon , Jeon, Yoon-A , Park, Kyung Jin , An, Hyun Joo , Kang, Seok Beom , Yun, Su Hyun , Choi, Young Hun , Lee, Young Jae

Abstract ▼ AI-Helper

A new mandarin hybrid cultivar called ‘Shinyegam’ was developed from a cross between ‘Kiyomi’ (Citrus unshiu × C. sinensis) and ‘Wilking’ (Citrus reticulata) at the Citrus Research Institute of the National Institute of Horticultural and Herbal Science in 2012. The ‘Shinyegam’ was extracted with 70% ethanol (SYGE), and polyphenol content was measured to assess total antioxidant activity of flavonoids. Radical scavenging activities of the extracts were examined using a-a-diphenyl-β-picrylhydrazyl (DPPH), 2,2-azino-bis 3-ethylbenzthiazoline-6-sulfonic acid (ABTS), and ferric reducing antioxidant power (FRAP) assays. SYGE showed high polyphenol and flavonoid content as well as strong DPPH, ABTS, and FRAP radical scavenging activity. We used a mouse model to assess the memory enhancing properties of SYGE and its ameliorating activities on learning and memory impairments. Drug-induced amnesia was initiated by scopolamine treatment (2 mg/kg, interperitoneal). SYGE administration (25 mg/kg, oral) significantly enhanced cognitive function and attenuated scopolamine-induced cognitive impairments as determined by novel object recognition, passive avoidance and Y-maze tasks. In addition, SYGE increased brain-derived neurotrophic factor (BDNF) expression in the hippocampus. These results suggest that SYGE enhances learning and memory in normal states and attenuates memory loss caused by cholinergic dysfunction.

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[국내논문] Memory enhancing activity of extract of new citrus cultivar ‘Shinyegam’in mice
마우스에서 국내 육성 신품종 ‘신예감’ 추출물의 기억력 증진 효과 원문보기

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[국내논문] Memory enhancing activity of extract of new citrus cultivar ‘Shinyegam’in mice 마우스에서 국내 육성 신품종 ‘신예감’ 추출물의 기억력 증진 효과 원문보기

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[국내논문] Memory enhancing activity of extract of new citrus cultivar ‘Shinyegam’in mice
마우스에서 국내 육성 신품종 ‘신예감’ 추출물의 기억력 증진 효과 원문보기

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