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Frontiers in pharmacology, v.10, 2019년, pp.435 -
Furini, Federica (Section of Rheumatology, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria Sant’Anna di Ferrara , Cona , Italy) , Giuliani, Anna Lisa (Department of Morphology, Surgery and Experimental Medicine, University of Ferrara , Ferrara , Italy) , Parlati, Mattia Erminio (Department of Morphology, Surgery and Experimental Medicine, University of Ferrara , Ferrara , Italy) , Govoni, Marcello (Section of Rheumatology, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria Sant’Anna di Ferrara , Cona , Italy) , Di Virgilio, Francesco (Department of Morphology, Surgery and Experimental Medicine, University of Ferrara , Ferrara , Italy) , Bortoluzzi, Alessandra (Section of Rheumatology, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria Sant’Anna di Ferrara , Cona , Italy)
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Introduction: P2X7R is an extracellular ATP-gated receptor involved in inflammatory and autoimmune processes mainly acting through NLPR3-inflammasome activation and IL-1β release, also implicated in lymphocyte proliferation and cellular apoptosis. Several observations from animal models and pat...
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