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Assembly of a GPCR-G Protein Complex 원문보기

Cell, v.177 no.5, 2019년, pp.1232 - 1242.e11  

Du, Yang (Molecular and Cellular Physiology, School of Medicine, Stanford University) ,  Duc, Nguyen Minh (School of Pharmacy, Sungkyunkwan University) ,  Rasmussen, Søren G.F. (Department of Neuroscience, University of Copenhagen) ,  Hilger, Daniel (Molecular and Cellular Physiology, School of Medicine, Stanford University) ,  Kubiak, Xavier (Department of Neuroscience, University of Copenhagen) ,  Wang, Liwen (Department of Nutrition, Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University) ,  Bohon, Jennifer (Department of Nutrition, Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University) ,  Kim, Hee Ryung (School of Pharmacy, Sungkyunkwan University) ,  Wegrecki, Marcin (Department of Neuroscience, University of Copenhagen) ,  Asuru, Awuri (Department of Nutrition, Center for Proteomics and Bioinformatics, School of Medicine, Case Western) ,  Jeong, Kyung Min ,  Lee, Jeongmi ,  Chance, Mark R. ,  Lodowski, David T. ,  Kobilka, Brian K. ,  Chung, Ka Young

Abstract AI-Helper 아이콘AI-Helper

Summary The activation of G proteins by G protein-coupled receptors (GPCRs) underlies the majority of transmembrane signaling by hormones and neurotransmitters. Recent structures of GPCR-G protein complexes obtained by crystallography and cryoelectron microscopy (cryo-EM) reveal similar interaction...

주제어

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