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Abstract

Summary The homeodomain is found in hundreds of transcription factors that play roles in fate determination via cell-autonomous regulation of gene expression. However, some homeodomain-containing proteins (HPs) are thought to be secreted and penetrate neighboring cells to affect the recipient cell fate. To determine whether this is a general characteristic of HPs, we carried out a large-scale validation for intercellular transfer of HPs. Our screening reveals that intercellular transfer is a general feature of HPs, but it occurs in a cell-context-sensitive manner. We also found the secretion is not solely a function of the homeodomain, but it is supported by external motifs containing hydrophobic residues. Thus, mutations of hydrophobic residues of HPs abrogate secretion and consequently interfere with HP function in recipient cells. Collectively, our study proposes that HP transfer is an intercellular communication method that couples the functions of interacting cells. Highlights Intercellular transfer is a general feature of homeodomain proteins (HPs) HP secretion is a cell-context-sensitive event Hydrophobic residues outside of the homeodomain support the secretion of HP Graphical Abstract [DISPLAY OMISSION]

  

참고문헌 (41)

  1. 1. Nat. Neurosci. Alvarez-Fischer 14 1260 2011 10.1038/nn.2916 Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I insults 
  2. 2. Cereb. Cortex Apulei 29 2384 2019 10.1093/cercor/bhy108 Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g 
  3. 3. Gene Expr. Patterns Balasubramanian 14 1 2014 10.1016/j.gep.2013.12.001 Expression of LIM-homeodomain transcription factors in the developing and mature mouse retina 
  4. 4. J. Neurosci. Beurdeley 32 9429 2012 10.1523/JNEUROSCI.0394-12.2012 Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex 
  5. 5. Nature Brunet 438 94 2005 10.1038/nature04110 The transcription factor Engrailed-2 guides retinal axons 
  6. 6. Subcell. Biochem. Burglin 52 95 2011 10.1007/978-90-481-9069-0_5 Homeodomain subtypes and functional diversity 
  7. 7. Eur. J. Biochem. Christiaens 269 2918 2002 10.1046/j.1432-1033.2002.02963.x Tryptophan fluorescence study of the interaction of penetratin peptides with model membranes 
  8. 8. Development Conte 137 2307 2010 10.1242/dev.045294 Proper differentiation of photoreceptors and amacrine cells depends on a regulatory loop between NeuroD and Six6 
  9. 9. Genome Res. Crooks 14 1188 2004 10.1101/gr.849004 WebLogo: a sequence logo generator 
  10. 10. Proc. Natl. Acad. Sci. USA de Melo 109 4657 2012 10.1073/pnas.1107488109 Injury-independent induction of reactive gliosis in retina by loss of function of the LIM homeodomain transcription factor Lhx2 
  11. 11. Neural Dev. De Toni 3 13 2008 10.1186/1749-8104-3-13 Regulation of survival in adult hippocampal and glioblastoma stem cell lineages by the homeodomain-only protein HOP 
  12. 12. Nat Genet. Dyer 34 53 2003 10.1038/ng1144 Prox1 function controls progenitor cell population and horizontal cell genesis in the mammalian retina 
  13. 13. Nucleic Acids Res. Edgar 32 1792 2004 10.1093/nar/gkh340 MUSCLE: multiple sequence alignment with high accuracy and high throughput 
  14. 14. Trends Genet. Gehring 6 323 1990 10.1016/0168-9525(90)90253-3 The structure of the homeodomain and its functional implications 
  15. 15. Annu. Rev. Cell Dev. Biol. Gorlich 15 607 1999 10.1146/annurev.cellbio.15.1.607 Transport between the cell nucleus and the cytoplasm 
  16. 16. Nat. Neurosci. Heintz 7 483 2004 10.1038/nn0504-483 Gene expression nervous system atlas (GENSAT) 
  17. 17. BMC Biol. Holland 5 47 2007 10.1186/1741-7007-5-47 Classification and nomenclature of all human homeobox genes 
  18. 18. Development Inoue 129 831 2002 Math3 and NeuroD regulate amacrine cell fate specification in the retina 
  19. 19. Proc. Natl. Acad. Sci. USA Joliot 88 1864 1991 10.1073/pnas.88.5.1864 Antennapedia homeobox peptide regulates neural morphogenesis 
  20. 20. Nat. Neurosci. Kay 14 965 2011 10.1038/nn.2859 Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate 
  21. 21. eLife Kim 3 e02671 2014 10.7554/eLife.02671 Regulation of retinal axon growth by secreted Vax1 homeodomain protein 
  22. 22. Genes Dev. Kim 20 2833 2006 10.1101/gad.1462706 Hedgehog-regulated localization of Vax2 controls eye development 
  23. 23. Cell Rep. Kim 13 990 2015 10.1016/j.celrep.2015.09.075 Mitochondrial protection by exogenous Otx2 in mouse retinal neurons 
  24. 24. eLife Kim 6 e21303 2017 10.7554/eLife.21303 The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity 
  25. 25. Nat. Med. Lim 21 395 2015 10.1038/nm.3824 Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy 
  26. 26. Science Lucas 270 1980 1995 10.1126/science.270.5244.1980 Selective trafficking of KNOTTED1 homeodomain protein and its mRNA through plasmodesmata 
  27. 27. Development Maizel 126 3183 1999 A short region of its homeodomain is necessary for engrailed nuclear export and secretion 
  28. 28. Nat. Neurosci. Miyata 15 414 2012 10.1038/nn.3023 Persistent cortical plasticity by upregulation of chondroitin 6-sulfation 
  29. 29. J. Comp. Neurol. Passini 388 495 1997 10.1002/(SICI)1096-9861(19971124)388:3<495::AID-CNE11>3.0.CO;2-L Vsx-1 and Vsx-2: differential expression of two paired-like homeobox genes during zebrafish and goldfish retinogenesis 
  30. 30. Nat. Rev. Genet. Pearson 6 893 2005 10.1038/nrg1726 Modulating Hox gene functions during animal body patterning 
  31. 31. Methods Mol. Biol. Pooga 1324 3 2015 10.1007/978-1-4939-2806-4_1 Classes of cell-penetrating peptides 
  32. 32. Neuron Prochiantz 85 911 2015 10.1016/j.neuron.2015.01.019 Homeoprotein signaling in the developing and adult nervous system 
  33. 33. Cell Rep. Rekaik 13 242 2015 10.1016/j.celrep.2015.08.076 Engrailed Homeoprotein Protects Mesencephalic Dopaminergic Neurons from Oxidative Stress 
  34. 34. Nat. Neurosci. Siegert 12 1197 2009 10.1038/nn.2370 Genetic address book for retinal cell types 
  35. 35. Hum. Mutat. Slavotinek 33 364 2012 10.1002/humu.21658 VAX1 mutation associated with microphthalmia, corpus callosum agenesis, and orofacial clefting: the first description of a VAX1 phenotype in humans 
  36. 36. Pharmacol. Rev. Spatazza 65 90 2013 10.1124/pr.112.006577 Homeoprotein signaling in development, health, and disease: a shaking of dogmas offers challenges and promises from bench to bed 
  37. 37. Cell Sugiyama 134 508 2008 10.1016/j.cell.2008.05.054 Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity 
  38. 38. Nucleic Acids Res. 45 D1 D158 2017 10.1093/nar/gkw1099 UniProt: the universal protein knowledgebase 
  39. 39. Genes Dev. Vacik 25 1783 2011 10.1101/gad.17227011 A novel mechanism for the transcriptional regulation of Wnt signaling in development 
  40. 40. Neuron Wizenmann 64 355 2009 10.1016/j.neuron.2009.09.018 Extracellular Engrailed participates in the topographic guidance of retinal axons in vivo 
  41. 41. Cell Yoon 148 752 2012 10.1016/j.cell.2011.11.064 Local translation of extranuclear lamin B promotes axon maintenance 

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