최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기BMC neuroscience, v.12, 2011년, pp.49 - 49
Huo, Yingqian (Department of Anatomy Yong Loo Lin school of Medicine National University of Singapore, 117597, Singapore) , Rangarajan, Parakalan (Department of Anatomy Yong Loo Lin school of Medicine National University of Singapore, 117597, Singapore) , Ling, Eng-Ang (Department of Anatomy Yong Loo Lin school of Medicine National University of Singapore, 117597, Singapore) , Dheen, S Thameem (Department of Anatomy Yong Loo Lin school of Medicine National University of Singapore, 117597, Singapore)
BackgroundNox-2 (also known as gp91phox), a subunit component of NADPH oxidases, generates reactive oxygen species (ROS). Nox-dependent ROS generation and nitric oxide (NO) release by microglia have been implicated in a variety of diseases in the central nervous system. Dexamethasone (Dex) has been ...
Dheen ST Kaur C Ling EA Microglial activation and its implications in the brain diseases Current Medicinal Chemistry 2007 14 11 1189 1197 10.2174/092986707780597961 17504139
Banati RB Gehrmann J Schubert P Kreutzberg GW Cytotoxicity of microglia Glia 1993 7 1 111 118 10.1002/glia.440070117 8423058
Chao C Hu S Molitor T Shaskan E Peterson P Activated microglia mediate neuronal cell injury via a nitric oxide mechanism The Journal of Immunology 1992 149 8 2736 2741 1383325
Kaur C Sivakumar V Ang LS Sundaresan A Hypoxic damage to the periventricular white matter in neonatal brain: role of vascular endothelial growth factor, nitric oxide and excitotoxicity Journal of Neurochemistry 2006 98 4 1200 1216 10.1111/j.1471-4159.2006.03964.x 16787408
Perry VH The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease Brain, Behavior, and Immunity 2004 18 5 407 413 10.1016/j.bbi.2004.01.004 15265532
Parvathenani LK Tertyshnikova S Greco CR Roberts SB Robertson B Posmantur R P2X7 Mediates Superoxide Production in Primary Microglia and Is Up-regulated in a Transgenic Mouse Model of Alzheimer's Disease Journal of Biological Chemistry 2003 278 15 13309 13317 10.1074/jbc.M209478200 12551918
Wu DC Teismann P Tieu K Vila M Jackson-Lewis V Ischiropoulos H Przedborski S NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease Proceedings of the National Academy of Sciences 2003 100 10 6145 6150 10.1073/pnas.0937239100
Glass GA DeLisle DM DeTogni P Gabig TG Magee BH Markert M Babior BM The respiratory burst oxidase of human neutrophils. Further studies of the purified enzyme Journal of Biological Chemistry 1986 261 28 13247 13251 3759962
Goldman R Ferber E Zort U Reactive oxygen species are involved in the activation of cellular phospholipase A2 FEBS Letters 1992 309 2 190 192 10.1016/0014-5793(92)81092-Z 1505682
Lavigne MC Malech HL Holland SM Leto TL Genetic requirement of p47phox for superoxide production by murine microglia The FASEB Journal 2001 15 2 285 287 11156938
Go YM Gipp JJ Mulcahy RT Jones DP H2O2-dependent Activation of GCLC-ARE4 Reporter Occurs by Mitogen-activated Protein Kinase Pathways without Oxidation of Cellular Glutathione or Thioredoxin-1 Journal of Biological Chemistry 2004 279 7 5837 5845 14638694
Qin L Liu Y Qian XUN Hong JS Block ML Microglial NADPH Oxidase Mediates Leucine Enkephalin Dopaminergic Neuroprotection Annals of the New York Academy of Sciences 2005 1053 1 107 120 10.1196/annals.1344.009 16179514
Kim YS Joh TH Microglia, major player in the brain inflammation: Their roles in the pathogenesis of Parkinson's disease Experimental and Molecular Medicine 2006 38 4 333 347 16953112
Tai YF Pavese N Gerhard A Tabrizi SJ Barker RA Brooks DJ Piccini P Imaging microglial activation in Huntington's disease Brain Research Bulletin 2007 72 2-3 148 151 10.1016/j.brainresbull.2006.10.029 17352938
Good PF Werner P Hsu A Olanow CW Perl DP Evidence for neuronal oxidative damage in Alzheimer's disease American Journal of Pathology 1996 149 1 21 28 8686745
Hald A Lotharius J Oxidative stress and inflammation in Parkinson's disease: is there a causal link? Experimental Neurology 2005 193 2 279 290 10.1016/j.expneurol.2005.01.013 15869932
Vodovotz Y Lucia MS Flanders KC Chesler L Xie QW Smith TW Weidner J Mumford R Webber R Nathan C Roberts AB Lippa CF Sporn MB Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease Journal of Experimental Medicine 1996 184 4 1425 1433 10.1084/jem.184.4.1425 8879214
Beckman JS Koppenol WH Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly American Journal of Physiology - Cell Physiology 1996 271 5 C1424 C1437
Estévez AG Jordán J Nitric oxide and superoxide, a deadly cocktail Volume 962 2002 207 211
Ruiz LM Bedoya G Salazar J García de OD Patiño PJ Dexamethasone Inhibits Apoptosis of Human Neutrophils Induced by Reactive Oxygen Species Inflammation 2002 26 5 215 222 10.1023/A:1019714618068 12238564
Korhonen R Lahti A Hämäläinen M Kankaanranta H Moilanen E Dexamethasone Inhibits Inducible Nitric-Oxide Synthase Expression and Nitric Oxide Production by Destabilizing mRNA in Lipopolysaccharide-Treated Macrophages Molecular Pharmacology 2002 62 3 698 704 10.1124/mol.62.3.698 12181447
Chang L Karin M Mammalian MAP kinase signalling cascades Nature 2001 410 6824 37 40 10.1038/35065000 11242034
Babcock AA Kuziel WA Rivest S Owens T Chemokine Expression by Glial Cells Directs Leukocytes to Sites of Axonal Injury in the CNS The Journal of Neuroscience 2003 23 21 7922 7930 12944523
Waetzig V Czeloth K Hidding U Mielke K Kanzow M Brecht S Goetz M Lucius R Herdegen T Hanisch UK c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia Glia 2005 50 3 235 246 10.1002/glia.20173 15739188
Clark A MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids? J Endocrinol 2003 178 1 5 12 10.1677/joe.0.1780005 12844330
Zhou Y Ling EA Dheen ST Dexamethasone suppresses monocyte chemoattractant protein-1 production via mitogen activated protein kinase phosphatase-1 dependent inhibition of Jun N-terminal kinase and p38 mitogen-activated protein kinase in activated rat microglia Journal of Neurochemistry 2007 102 3 667 678 10.1111/j.1471-4159.2007.04535.x 17403137
Golde S Coles A Lindquist JA Compston A Decreased iNOS synthesis mediates dexamethasone-induced protection of neurons from inflammatory injury in vitro European Journal of Neuroscience 2003 18 9 2527 2537 10.1046/j.1460-9568.2003.02917.x 14622153
Lieb K Engels S Fiebich BL Inhibition of LPS-induced iNOS and NO synthesis in primary rat microglial cells Neurochemistry International 2003 42 2 131 137 10.1016/S0197-0186(02)00076-1 12421593
Abate C Patel L Rauscher Iii FJ Curran T Redox regulation of Fos and Jun DNA-binding activity in vitro Science 1990 249 4973 1157 1161 10.1126/science.2118682 2118682
Clark RA Valente AJ Nuclear factor kappa B activation by NADPH oxidases Mechanisms of Ageing and Development 125 10-11 799 810
Sun Y Oberley LW Redox regulation of transcriptional activators Free Radical Biology and Medicine 1996 21 3 335 348 10.1016/0891-5849(96)00109-8 8855444
Walder CE Green SP Darbonne WC Mathias J Rae J Dinauer MC Curnutte JT Thomas GR Ischemic Stroke Injury Is Reduced in Mice Lacking a Functional NADPH Oxidase Stroke 1997 28 11 2252 2258 9368573
Kusaka I Kusaka G Zhou C Ishikawa M Nanda A Granger DN Zhang JH Tang J Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury American Journal of Physiology - Heart and Circulatory Physiology 2004 286 6 H2442 H2451 10.1152/ajpheart.01169.2003 15148062
van der Goes A Brouwer J Hoekstra K Roos D van den Berg TK Dijkstra CD Reactive oxygen species are required for the phagocytosis of myelin by macrophages Journal of neuroimmunology 1998 92 1 67 75 10.1016/S0165-5728(98)00175-1 9916881
Zekry D Epperson TK Krause KH A Role for NOX NADPH Oxidases in Alzheimer's Disease and Other Types of Dementia? IUBMB Life 2003 55 6 307 313 10.1080/1521654031000153049 12938732
Lee YB Schrader JW Kim SU p38 MAP Kinase regulates TNF-[alpha] production in human astrocytes and microglia by multiple mechanisms Cytokine 2000 12 7 874 880 10.1006/cyto.2000.0688 10880231
Li Y Liu L Barger SW Mrak RE Griffin WST Vitamin E suppression of microglial activation is neuroprotective Journal of Neuroscience Research 2001 66 2 163 170 10.1002/jnr.1208 11592111
Deng YY Lu J Ling EA Kaur C Monocyte chemoattractant protein-1 (MCP-1) produced via NF-κB signaling pathway mediates migration of amoeboid microglia in the periventricular white matter in hypoxic neonatal rats Glia 2009 57 6 604 621 10.1002/glia.20790 18942743
Chen P Li J Barnes J Kokkonen GC Lee JC Liu Y Restraint of Proinflammatory Cytokine Biosynthesis by Mitogen-Activated Protein Kinase Phosphatase-1 in Lipopolysaccharide-Stimulated Macrophages The Journal of Immunology 2002 169 11 6408 6416 12444149
Engelbrecht Y de Wet H Horsch K Langeveldt CR Hough FS Hulley PA Glucocorticoids Induce Rapid Up-Regulation of Mitogen-Activated Protein Kinase Phosphatase-1 and Dephosphorylation of Extracellular Signal-Regulated Kinase and Impair Proliferation in Human and Mouse Osteoblast Cell Lines Endocrinology 2003 144 2 412 422 10.1210/en.2002-220769 12538600
Kassel O Sancono A Kratzschmar J Kreft B Stassen M Cato ACB Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1 EMBO J 2001 20 24 7108 7116 10.1093/emboj/20.24.7108 11742987
Lasa M Abraham SM Boucheron C Saklatvala J Clark AR Dexamethasone Causes Sustained Expression of Mitogen-Activated Protein Kinase (MAPK) Phosphatase 1 and Phosphatase-Mediated Inhibition of MAPK p38 Mol Cell Biol 2002 22 22 7802 7811 10.1128/MCB.22.22.7802-7811.2002 12391149
Shepherd EG Zhao Q Welty SE Hansen TN Smith CV Liu Y The Function of Mitogen-activated Protein Kinase Phosphatase-1 in Peptidoglycan-stimulated Macrophages Journal of Biological Chemistry 2004 279 52 54023 54031 10.1074/jbc.M408444200 15485842
Eljaschewitsch E Witting A Mawrin C Lee T Schmidt PM Wolf S Hoertnagl H Raine CS Schneider-Stock R Nitsch R Ullrich O The Endocannabinoid Anandamide Protects Neurons during CNS Inflammation by Induction of MKP-1 in Microglial Cells Neuron 2006 49 1 67 79 10.1016/j.neuron.2005.11.027 16387640
Zhou JY Liu Y Wu GS The Role of Mitogen-Activated Protein Kinase Phosphatase-1 in Oxidative Damage-Induced Cell Death Cancer Research 2006 66 9 4888 4894 10.1158/0008-5472.CAN-05-4229 16651445
Hou N Torii S Saito N Hosaka M Takeuchi T Reactive Oxygen Species-Mediated Pancreatic {beta}-Cell Death Is Regulated by Interactions between Stress-Activated Protein Kinases, p38 and c-Jun N-Terminal Kinase, and Mitogen-Activated Protein Kinase Phosphatases Endocrinology 2008 149 4 1654 1665 10.1210/en.2007-0988 18187551
Kaneto H Xu G Fujii N Kim S Bonner-Weir S Weir GC Involvement of c-Jun N-terminal Kinase in Oxidative Stress-mediated Suppression of Insulin Gene Expression Journal of Biological Chemistry 2002 277 33 30010 30018 10.1074/jbc.M202066200 12011047
Livak KJ Schmittgen TD Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2-[Delta][Delta]CT Method Methods 2001 25 4 402 408 10.1006/meth.2001.1262 11846609
Wu JJ Zhang L Bennett AM The Noncatalytic Amino Terminus of Mitogen-Activated Protein Kinase Phosphatase 1 Directs Nuclear Targeting and Serum Response Element Transcriptional Regulation Mol Cell Biol 2005 25 11 4792 4803 10.1128/MCB.25.11.4792-4803.2005 15899879
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.