$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Dexamethasone inhibits the Nox-dependent ROS production via suppression of MKP-1-dependent MAPK pathways in activated microglia 원문보기

BMC neuroscience, v.12, 2011년, pp.49 - 49  

Huo, Yingqian (Department of Anatomy Yong Loo Lin school of Medicine National University of Singapore, 117597, Singapore) ,  Rangarajan, Parakalan (Department of Anatomy Yong Loo Lin school of Medicine National University of Singapore, 117597, Singapore) ,  Ling, Eng-Ang (Department of Anatomy Yong Loo Lin school of Medicine National University of Singapore, 117597, Singapore) ,  Dheen, S Thameem (Department of Anatomy Yong Loo Lin school of Medicine National University of Singapore, 117597, Singapore)

Abstract AI-Helper 아이콘AI-Helper

BackgroundNox-2 (also known as gp91phox), a subunit component of NADPH oxidases, generates reactive oxygen species (ROS). Nox-dependent ROS generation and nitric oxide (NO) release by microglia have been implicated in a variety of diseases in the central nervous system. Dexamethasone (Dex) has been ...

주제어

참고문헌 (49)

  1. Dheen ST Kaur C Ling EA Microglial activation and its implications in the brain diseases Current Medicinal Chemistry 2007 14 11 1189 1197 10.2174/092986707780597961 17504139 

  2. Banati RB Gehrmann J Schubert P Kreutzberg GW Cytotoxicity of microglia Glia 1993 7 1 111 118 10.1002/glia.440070117 8423058 

  3. Chao C Hu S Molitor T Shaskan E Peterson P Activated microglia mediate neuronal cell injury via a nitric oxide mechanism The Journal of Immunology 1992 149 8 2736 2741 1383325 

  4. Kaur C Sivakumar V Ang LS Sundaresan A Hypoxic damage to the periventricular white matter in neonatal brain: role of vascular endothelial growth factor, nitric oxide and excitotoxicity Journal of Neurochemistry 2006 98 4 1200 1216 10.1111/j.1471-4159.2006.03964.x 16787408 

  5. Perry VH The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease Brain, Behavior, and Immunity 2004 18 5 407 413 10.1016/j.bbi.2004.01.004 15265532 

  6. Parvathenani LK Tertyshnikova S Greco CR Roberts SB Robertson B Posmantur R P2X7 Mediates Superoxide Production in Primary Microglia and Is Up-regulated in a Transgenic Mouse Model of Alzheimer's Disease Journal of Biological Chemistry 2003 278 15 13309 13317 10.1074/jbc.M209478200 12551918 

  7. Wu DC Teismann P Tieu K Vila M Jackson-Lewis V Ischiropoulos H Przedborski S NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease Proceedings of the National Academy of Sciences 2003 100 10 6145 6150 10.1073/pnas.0937239100 

  8. Glass GA DeLisle DM DeTogni P Gabig TG Magee BH Markert M Babior BM The respiratory burst oxidase of human neutrophils. Further studies of the purified enzyme Journal of Biological Chemistry 1986 261 28 13247 13251 3759962 

  9. Goldman R Ferber E Zort U Reactive oxygen species are involved in the activation of cellular phospholipase A2 FEBS Letters 1992 309 2 190 192 10.1016/0014-5793(92)81092-Z 1505682 

  10. Lavigne MC Malech HL Holland SM Leto TL Genetic requirement of p47phox for superoxide production by murine microglia The FASEB Journal 2001 15 2 285 287 11156938 

  11. Go YM Gipp JJ Mulcahy RT Jones DP H2O2-dependent Activation of GCLC-ARE4 Reporter Occurs by Mitogen-activated Protein Kinase Pathways without Oxidation of Cellular Glutathione or Thioredoxin-1 Journal of Biological Chemistry 2004 279 7 5837 5845 14638694 

  12. Qin L Liu Y Qian XUN Hong JS Block ML Microglial NADPH Oxidase Mediates Leucine Enkephalin Dopaminergic Neuroprotection Annals of the New York Academy of Sciences 2005 1053 1 107 120 10.1196/annals.1344.009 16179514 

  13. Kim YS Joh TH Microglia, major player in the brain inflammation: Their roles in the pathogenesis of Parkinson's disease Experimental and Molecular Medicine 2006 38 4 333 347 16953112 

  14. Tai YF Pavese N Gerhard A Tabrizi SJ Barker RA Brooks DJ Piccini P Imaging microglial activation in Huntington's disease Brain Research Bulletin 2007 72 2-3 148 151 10.1016/j.brainresbull.2006.10.029 17352938 

  15. Good PF Werner P Hsu A Olanow CW Perl DP Evidence for neuronal oxidative damage in Alzheimer's disease American Journal of Pathology 1996 149 1 21 28 8686745 

  16. Hald A Lotharius J Oxidative stress and inflammation in Parkinson's disease: is there a causal link? Experimental Neurology 2005 193 2 279 290 10.1016/j.expneurol.2005.01.013 15869932 

  17. Vodovotz Y Lucia MS Flanders KC Chesler L Xie QW Smith TW Weidner J Mumford R Webber R Nathan C Roberts AB Lippa CF Sporn MB Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease Journal of Experimental Medicine 1996 184 4 1425 1433 10.1084/jem.184.4.1425 8879214 

  18. Beckman JS Koppenol WH Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly American Journal of Physiology - Cell Physiology 1996 271 5 C1424 C1437 

  19. Estévez AG Jordán J Nitric oxide and superoxide, a deadly cocktail Volume 962 2002 207 211 

  20. Ruiz LM Bedoya G Salazar J García de OD Patiño PJ Dexamethasone Inhibits Apoptosis of Human Neutrophils Induced by Reactive Oxygen Species Inflammation 2002 26 5 215 222 10.1023/A:1019714618068 12238564 

  21. Korhonen R Lahti A Hämäläinen M Kankaanranta H Moilanen E Dexamethasone Inhibits Inducible Nitric-Oxide Synthase Expression and Nitric Oxide Production by Destabilizing mRNA in Lipopolysaccharide-Treated Macrophages Molecular Pharmacology 2002 62 3 698 704 10.1124/mol.62.3.698 12181447 

  22. Chang L Karin M Mammalian MAP kinase signalling cascades Nature 2001 410 6824 37 40 10.1038/35065000 11242034 

  23. Babcock AA Kuziel WA Rivest S Owens T Chemokine Expression by Glial Cells Directs Leukocytes to Sites of Axonal Injury in the CNS The Journal of Neuroscience 2003 23 21 7922 7930 12944523 

  24. Waetzig V Czeloth K Hidding U Mielke K Kanzow M Brecht S Goetz M Lucius R Herdegen T Hanisch UK c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia Glia 2005 50 3 235 246 10.1002/glia.20173 15739188 

  25. Clark A MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids? J Endocrinol 2003 178 1 5 12 10.1677/joe.0.1780005 12844330 

  26. Zhou Y Ling EA Dheen ST Dexamethasone suppresses monocyte chemoattractant protein-1 production via mitogen activated protein kinase phosphatase-1 dependent inhibition of Jun N-terminal kinase and p38 mitogen-activated protein kinase in activated rat microglia Journal of Neurochemistry 2007 102 3 667 678 10.1111/j.1471-4159.2007.04535.x 17403137 

  27. Golde S Coles A Lindquist JA Compston A Decreased iNOS synthesis mediates dexamethasone-induced protection of neurons from inflammatory injury in vitro European Journal of Neuroscience 2003 18 9 2527 2537 10.1046/j.1460-9568.2003.02917.x 14622153 

  28. Lieb K Engels S Fiebich BL Inhibition of LPS-induced iNOS and NO synthesis in primary rat microglial cells Neurochemistry International 2003 42 2 131 137 10.1016/S0197-0186(02)00076-1 12421593 

  29. Abate C Patel L Rauscher Iii FJ Curran T Redox regulation of Fos and Jun DNA-binding activity in vitro Science 1990 249 4973 1157 1161 10.1126/science.2118682 2118682 

  30. Clark RA Valente AJ Nuclear factor kappa B activation by NADPH oxidases Mechanisms of Ageing and Development 125 10-11 799 810 

  31. Sun Y Oberley LW Redox regulation of transcriptional activators Free Radical Biology and Medicine 1996 21 3 335 348 10.1016/0891-5849(96)00109-8 8855444 

  32. Walder CE Green SP Darbonne WC Mathias J Rae J Dinauer MC Curnutte JT Thomas GR Ischemic Stroke Injury Is Reduced in Mice Lacking a Functional NADPH Oxidase Stroke 1997 28 11 2252 2258 9368573 

  33. Kusaka I Kusaka G Zhou C Ishikawa M Nanda A Granger DN Zhang JH Tang J Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury American Journal of Physiology - Heart and Circulatory Physiology 2004 286 6 H2442 H2451 10.1152/ajpheart.01169.2003 15148062 

  34. van der Goes A Brouwer J Hoekstra K Roos D van den Berg TK Dijkstra CD Reactive oxygen species are required for the phagocytosis of myelin by macrophages Journal of neuroimmunology 1998 92 1 67 75 10.1016/S0165-5728(98)00175-1 9916881 

  35. Zekry D Epperson TK Krause KH A Role for NOX NADPH Oxidases in Alzheimer's Disease and Other Types of Dementia? IUBMB Life 2003 55 6 307 313 10.1080/1521654031000153049 12938732 

  36. Lee YB Schrader JW Kim SU p38 MAP Kinase regulates TNF-[alpha] production in human astrocytes and microglia by multiple mechanisms Cytokine 2000 12 7 874 880 10.1006/cyto.2000.0688 10880231 

  37. Li Y Liu L Barger SW Mrak RE Griffin WST Vitamin E suppression of microglial activation is neuroprotective Journal of Neuroscience Research 2001 66 2 163 170 10.1002/jnr.1208 11592111 

  38. Deng YY Lu J Ling EA Kaur C Monocyte chemoattractant protein-1 (MCP-1) produced via NF-κB signaling pathway mediates migration of amoeboid microglia in the periventricular white matter in hypoxic neonatal rats Glia 2009 57 6 604 621 10.1002/glia.20790 18942743 

  39. Chen P Li J Barnes J Kokkonen GC Lee JC Liu Y Restraint of Proinflammatory Cytokine Biosynthesis by Mitogen-Activated Protein Kinase Phosphatase-1 in Lipopolysaccharide-Stimulated Macrophages The Journal of Immunology 2002 169 11 6408 6416 12444149 

  40. Engelbrecht Y de Wet H Horsch K Langeveldt CR Hough FS Hulley PA Glucocorticoids Induce Rapid Up-Regulation of Mitogen-Activated Protein Kinase Phosphatase-1 and Dephosphorylation of Extracellular Signal-Regulated Kinase and Impair Proliferation in Human and Mouse Osteoblast Cell Lines Endocrinology 2003 144 2 412 422 10.1210/en.2002-220769 12538600 

  41. Kassel O Sancono A Kratzschmar J Kreft B Stassen M Cato ACB Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1 EMBO J 2001 20 24 7108 7116 10.1093/emboj/20.24.7108 11742987 

  42. Lasa M Abraham SM Boucheron C Saklatvala J Clark AR Dexamethasone Causes Sustained Expression of Mitogen-Activated Protein Kinase (MAPK) Phosphatase 1 and Phosphatase-Mediated Inhibition of MAPK p38 Mol Cell Biol 2002 22 22 7802 7811 10.1128/MCB.22.22.7802-7811.2002 12391149 

  43. Shepherd EG Zhao Q Welty SE Hansen TN Smith CV Liu Y The Function of Mitogen-activated Protein Kinase Phosphatase-1 in Peptidoglycan-stimulated Macrophages Journal of Biological Chemistry 2004 279 52 54023 54031 10.1074/jbc.M408444200 15485842 

  44. Eljaschewitsch E Witting A Mawrin C Lee T Schmidt PM Wolf S Hoertnagl H Raine CS Schneider-Stock R Nitsch R Ullrich O The Endocannabinoid Anandamide Protects Neurons during CNS Inflammation by Induction of MKP-1 in Microglial Cells Neuron 2006 49 1 67 79 10.1016/j.neuron.2005.11.027 16387640 

  45. Zhou JY Liu Y Wu GS The Role of Mitogen-Activated Protein Kinase Phosphatase-1 in Oxidative Damage-Induced Cell Death Cancer Research 2006 66 9 4888 4894 10.1158/0008-5472.CAN-05-4229 16651445 

  46. Hou N Torii S Saito N Hosaka M Takeuchi T Reactive Oxygen Species-Mediated Pancreatic {beta}-Cell Death Is Regulated by Interactions between Stress-Activated Protein Kinases, p38 and c-Jun N-Terminal Kinase, and Mitogen-Activated Protein Kinase Phosphatases Endocrinology 2008 149 4 1654 1665 10.1210/en.2007-0988 18187551 

  47. Kaneto H Xu G Fujii N Kim S Bonner-Weir S Weir GC Involvement of c-Jun N-terminal Kinase in Oxidative Stress-mediated Suppression of Insulin Gene Expression Journal of Biological Chemistry 2002 277 33 30010 30018 10.1074/jbc.M202066200 12011047 

  48. Livak KJ Schmittgen TD Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2-[Delta][Delta]CT Method Methods 2001 25 4 402 408 10.1006/meth.2001.1262 11846609 

  49. Wu JJ Zhang L Bennett AM The Noncatalytic Amino Terminus of Mitogen-Activated Protein Kinase Phosphatase 1 Directs Nuclear Targeting and Serum Response Element Transcriptional Regulation Mol Cell Biol 2005 25 11 4792 4803 10.1128/MCB.25.11.4792-4803.2005 15899879 

관련 콘텐츠

원문 보기

원문 URL 링크

*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로