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Ethacrynic acid inhibits STAT3 activity through the modulation of SHP2 and PTP1B tyrosine phosphatases in DU145 prostate carcinoma cells

Biochemical pharmacology, v.175, 2020년, pp.113920 -   

Lee, Yu-Jin (Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology) ,  Song, Harim (Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology) ,  Yoon, Yae Jin (Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology) ,  Park, Seung-Jin (University of Science and Technology in Korea) ,  Kim, Seon-Young (University of Science and Technology in Korea) ,  Cho Han, Dong (Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology) ,  Kwon, Byoung-Mog (Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology)

Abstract AI-Helper 아이콘AI-Helper

Abstract To identify signal transducer and activator of transcription factor 3 (STAT3) inhibitors, we generated STAT3-dependent gene expression signature by analyzing gene expression profiles of DU145 cancer cells treated with STAT3 inhibitor, piperlongumine and 2-hydroxycinnamaldehyde. Then we exp...

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