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Bioinformatics and Moonlighting Proteins 원문보기

Frontiers in bioengineering and biotechnology, v.3, 2015년, pp.90 -   

Hernández, Sergio (Institut de Biotecnologia i Biomedicina and Departament de Bioquí) ,  Franco, Luís (mica i Biologia Molecular, Universitat Autò) ,  Calvo, Alejandra (noma de Barcelona , Barcelona , Spain) ,  Ferragut, Gabriela (Institut de Biotecnologia i Biomedicina and Departament de Bioquí) ,  Hermoso, Antoni (mica i Biologia Molecular, Universitat Autò) ,  Amela, Isaac (noma de Barcelona , Barcelona , Spain) ,  Gómez, Antonio (Laboratorio de Inmunologí) ,  Querol, Enrique (a, Universidad de la Repú) ,  Cedano, Juan (blica Regional Norte-Salto , Salto , Uruguay)

Abstract AI-Helper 아이콘AI-Helper

Multitasking or moonlighting is the capability of some proteins to execute two or more biochemical functions. Usually, moonlighting proteins are experimentally revealed by serendipity. For this reason, it would be helpful that Bioinformatics could predict this multifunctionality, especially because ...

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참고문헌 (46)

  1. Aloy P. Querol E. Aviles F. X. Sternberg M. J. ( 2001 ). Automated structure-based prediction of functional sites in proteins: applications to assessing the validity of inheriting protein function from homology in genome annotation and to protein docking . J. Mol. Biol. 311 , 395 – 408 . 10.1006/jmbi.2001.4870S0022-2836(01)94870-3 11478868 

  2. Altschul S. F. Madden T. L. Schaffer A. A. Zhang J. Zhang Z. Miller W. ( 1997 ). Gapped BLAST and PSI-BLAST: a new generation of protein database search programs . Nucleic Acids Res. 25 , 3389 – 3402 . 10.1093/nar/25.17.3389 9254694 

  3. Ashburner M. Ball C. A. Blake J. A. Botstein D. Butler H. Cherry J. M. ( 2000 ). Gene ontology: tool for the unification of biology. The gene ontology consortium . Nat. Genet. 25 , 25 – 29 . 10.1038/75556 10802651 

  4. Becker E. Robisson B. Chapple C. E. Guenoche A. Brun C. ( 2012 ). Multifunctional proteins revealed by overlapping clustering in protein interaction network . Bioinformatics 28 , 84 – 90 . 10.1093/bioinformatics/btr621btr621 22080466 

  5. Beissbarth T. Speed T. P. ( 2004 ). GOstat: find statistically overrepresented gene ontologies within a group of genes . Bioinformatics 20 , 1464 – 1465 . 10.1093/bioinformatics/bth088bth088 14962934 

  6. Cedano J. Aloy P. Perez-Pons J. A. Querol E. ( 1997 ). Relation between amino acid composition and cellular location of proteins . J. Mol. Biol. 266 , 594 – 600 . 10.1006/jmbi.1996.0804 9067612 

  7. Copley S. D. ( 2012 ). Moonlighting is mainstream: paradigm adjustment required . Bioessays 34 , 578 – 588 . 10.1002/bies.201100191 22696112 

  8. Espadaler J. Eswar N. Querol E. Avilés F. X. Sali A. Martí-Renom M. ( 2008 ). Prediction of enzyme function by combining sequence similarity and protein interactions . BMC Bioinformatics 9 : 249 . 10.1186/1471-2105-9-249 18505562 

  9. Finn R. D. Mistry J. Schuster-Bockler B. Griffiths-Jones S. Hollich V. Lassmann T. ( 2006 ). Pfam: clans, web tools and services . Nucleic Acids Res. 34 , D247 – D251 . 10.1093/nar/gkj149 16381856 

  10. Gancedo C. Flores C. L. ( 2008 ). Moonlighting proteins in yeasts . Microbiol. Mol. Biol. Rev. 72 , 197 – 210 . 10.1128/MMBR.00036-07 18322039 

  11. Gomez A. Cedano J. Espadaler J. Hermoso A. Pinol J. Querol E. ( 2008 ). Prediction of protein function improving sequence remote alignment search by a fuzzy logic algorithm . Protein J. 27 , 130 – 139 . 10.1007/s10930-007-9116-x 18066655 

  12. Gomez A. Domedel N. Cedano J. Pinol J. Querol E. ( 2003 ). Do current sequence analysis algorithms disclose multifunctional (moonlighting) proteins? Bioinformatics 19 , 895 – 896 . 10.1093/bioinformatics/btg111 12724303 

  13. Gomez A. Hernandez S. Amela I. Pinol J. Cedano J. Querol E. ( 2011 ). Do protein-protein interaction databases identify moonlighting proteins? Mol. Biosyst. 7 , 2379 – 2382 . 10.1039/c1mb05180f 21677976 

  14. Gotz S. Garcia-Gomez J. M. Terol J. Williams T. D. Nagaraj S. H. Nueda M. J. ( 2008 ). High-throughput functional annotation and data mining with the Blast2GO suite . Nucleic Acids Res. 36 , 3420 – 3435 . 10.1093/nar/gkn176gkn176 18445632 

  15. Guex N. Peitsch M. C. ( 1997 ). SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling . Electrophoresis 18 , 2714 – 2723 . 10.1002/elps.1150181505 9504803 

  16. Heger A. Wilton C. A. Sivakumar A. Holm L. ( 2005 ). ADDA: a domain database with global coverage of the protein universe . Nucleic Acids Res. 33 (Database issue) , D188 – D191 . 15608174 

  17. Henderson B. Martin A. ( 2011 ). Bacterial virulence in the moonlight: multitasking bacterial moonlighting proteins are virulence determinants in infectious disease . Infect. Immun. 79 , 3476 – 3491 . 10.1128/IAI.00179-11IAI.00179-11 21646455 

  18. Henikoff S. Henikoff J. G. Pietrokovski S. ( 1999 ). Blocks+: a non-redundant database of protein alignment blocks derived from multiple compilations . Bioinformatics 15 , 471 – 479 . 10.1093/bioinformatics/15.6.471 10383472 

  19. Hernández S. Amela I. Cedano J. Piñol J. Perez-Pons J. A. Mozo-Villarias A. ( 2012 ). Do moonlighting proteins belong to the intrinsic disordered proteins class? J. Proteomics Bioinform. 5 , 262 – 264 . 10.1371/journal.pone.0005566 

  20. Hernandez S. Calvo A. Ferragut G. Franco L. Hermoso A. Amela I. ( 2014a ). Can bioinformatics help in the identification of moonlighting proteins? Biochem. Soc. Trans. 42 , 1692 – 1697 . 10.1042/BST20140241BST20140241 25399591 

  21. Hernandez S. Ferragut G. Amela I. Perez-Pons J. Pinol J. Mozo-Villarias A. ( 2014b ). MultitaskProtDB: a database of multitasking proteins . Nucleic Acids Res. 42 , D517 – D520 . 10.1093/nar/gkt1153gkt1153 24253302 

  22. Higurashi M. Ishida T. Kinoshita K. ( 2009 ). PiSite: a database of protein interaction sites using multiple binding states in the PDB . Nucleic Acids Res. 37 , D360 – D364 . 10.1093/nar/gkn659gkn659 18836195 

  23. Huberts D. H. Van Der Klei I. J. ( 2010 ). Moonlighting proteins: an intriguing mode of multitasking . Biochim. Biophys. Acta 1803 , 520 – 525 . 10.1016/j.bbamcr.2010.01.022S0167-4889(10)00035-2 20144902 

  24. Hunter S. Jones P. Mitchell A. Apweiler R. Attwood T. K. Bateman A. ( 2012 ). InterPro in 2011: new developments in the family and domain prediction database . Nucleic Acids Res. 40 , D306 – D312 . 10.1093/nar/gkr948gkr948 22096229 

  25. Jeffery C. J. ( 1999 ). Moonlighting proteins . Trends Biochem. Sci. 24 , 8 – 11 . 10.1016/S0968-0004(98)01335-8 10087914 

  26. Jeffery C. J. ( 2003 ). Moonlighting proteins: old proteins learning new tricks . Trends Genet. 19 , 415 – 417 . 10.1016/S0168-9525(03)00167-7 12902157 

  27. Jeffery C. J. ( 2004 ). Molecular mechanisms for multitasking: recent crystal structures of moonlighting proteins . Curr. Opin. Struct. Biol. 14 , 663 – 668 . 10.1016/j.sbi.2004.10.001 15582389 

  28. Jeffery C. J. ( 2009 ). Moonlighting proteins – an update . Mol. Biosyst. 5 , 345 – 350 . 10.1039/b900658n 19396370 

  29. Jeffery C. J. ( 2011 ). Proteins with neomorphic moonlighting functions in disease . IUBMB Life 63 , 489 – 494 . 10.1002/iub.504 21698752 

  30. Jeffery C. J. ( 2014 ). An introduction to protein moonlighting . Biochem. Soc. Trans. 42 , 1679 – 1683 . 10.1042/BST20140226BST20140226 25399589 

  31. Kelley L. A. Sternberg M. J. ( 2009 ). Protein structure prediction on the web: a case study using the Phyre server . Nat. Protoc. 4 , 363 – 371 . 10.1038/nprot.2009.2nprot.2009.2 19247286 

  32. Khan I. Chen Y. Dong T. Hong X. Tekeuchi R. Mori H. ( 2014 ). Genome-scale identification and characterization of moonlighting proteins . Biol. Direct 9 , 30 . 10.1186/s13062-014-0030-9 25497125 

  33. Khan I. Chitale M. Rayon C. Kihara D. ( 2012 ). Evaluation of function predictions by PFP, ESG, and PSI-BLAST for moonlighting proteins . BMC Proc. 6 ( Suppl. 7 ): S5 . 10.1186/1753-6561-6-S7-S51753-6561-6-S7-S5 23173871 

  34. Khan I. Kihara D. ( 2014 ). Computational characterization of moonlighting proteins . Biochem. Soc. Trans. 42 , 1780 – 1785 . 10.1042/BST20140214 25399606 

  35. Lievens S. Eyckerman S. Lemmens I. Tavernier J. ( 2010 ). Large-scale protein interactome mapping: strategies and opportunities . Expert Rev. Proteomics 7 , 679 – 690 . 10.1586/epr.10.30 20973641 

  36. Mani M. Chen C. Amblee V. Liu H. Mathur T. Zwicke G. ( 2015 ). MoonProt: a database for proteins that are known to moonlight . Nucleic Acids Res. 43 , D277 – D282 . 10.1093/nar/gku954 25324305 

  37. Nakai K. Horton P. ( 1999 ). PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization . Trends Biochem. Sci. 24 , 34 – 36 . 10.1016/S0968-0004(98)01336-X 10087920 

  38. Nobeli I. Favia A. D. Thornton J. M. ( 2009 ). Protein promiscuity and its implications for biotechnology . Nat. Biotechnol. 27 , 157 – 167 . 10.1038/nbt1519nbt1519 19204698 

  39. Parraga-Nino N. Colome-Calls N. Canals F. Querol E. Ferrer-Navarro M. ( 2012 ). A comprehensive proteome of Mycoplasma genitalium . J. Proteome Res. 11 , 3305 – 3316 . 10.1021/pr300084c 22582988 

  40. Piatigorsky J. ( 2008 ). Lens and cornea: the “refracton hypothesis” . Semin. Cell Dev. Biol. 19 , 69 – 70 . 10.1016/j.semcdb.2007.10.010 18054835 

  41. Prieto C. Rivas M. J. Sanchez J. M. Lopez-Fidalgo J. De Las Rivas J. ( 2006 ). Algorithm to find gene expression profiles of deregulation and identify families of disease-altered genes . Bioinformatics 22 , 1103 – 1110 . 10.1093/bioinformatics/btl053 16500942 

  42. Simonetti F. L. Teppa E. Chernomoretz A. Nielsen M. Marino Buslje C. ( 2013 ). MISTIC: mutual information server to infer coevolution . Nucleic Acids Res. 41 , W8 – W14 . 10.1093/nar/gkt427gkt427 23716641 

  43. Sriram G. Martinez J. A. McCabe E. R. Liao J. C. Dipple K. M. ( 2005 ). Single-gene disorders: what role could moonlighting enzymes play? Am. J. Hum. Genet. 76 , 911 – 924 . 10.1086/430799 15877277 

  44. Tompa P. Szasz C. Buday L. ( 2005 ). Structural disorder throws new light on moonlighting . Trends Biochem. Sci. 30 , 484 – 489 . 10.1016/j.tibs.2005.07.008 16054818 

  45. Wistow G. Piatigorsky J. ( 1987 ). Recruitment of enzymes as lens structural proteins . Science 236 , 1554 – 1556 . 10.1126/science.3589669 3589669 

  46. Wool I. G. ( 1996 ). Extraribosomal functions of ribosomal proteins . Trends Biochem. Sci. 21 , 164 – 165 . 10.1016/0968-0004(96)20011-8 8871397 

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