Bee venom may be administered in a standardized formulation with or without relatively small amounts of anesthetic. In particular, the results of the combination of venom and anesthetic dramatically decreased pain and discomfort for patients undergoing apitherapy.
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1. A standardized bee venom preparation comprising a liquid carrier, from about 0.1 milligram (mg) to about 1.0 mg of pure melittin, and from about 400 microgram (mcg) to about 4,500 mcg of total protein per milliliter (mL) of said standardized bee venom preparation, wherein said standardized bee ve
1. A standardized bee venom preparation comprising a liquid carrier, from about 0.1 milligram (mg) to about 1.0 mg of pure melittin, and from about 400 microgram (mcg) to about 4,500 mcg of total protein per milliliter (mL) of said standardized bee venom preparation, wherein said standardized bee venom preparation exhibits 40 to 100 honey bee hyaluronidase units per mL (HHU/mL) of hyaluronidase activity when diluted to 100 mcg/mL and is capable of inhibiting gelatin induced aggregation of erythrocytes of 3-5 millimeter per hour (mm/H). 2. The standardized bee venom preparation of claim 1, wherein the liquid carrier is sterile deionized water or physiological saline solution. 3. The standardized bee venom preparation of claim 1, further comprising an excipient selected from the group consisting of a viscosity modifier, preservative, additive, sodium chloride, saccharide, benzyl alcohol, methyl paraban and mixtures thereof. 4. The standardized bee venom preparation of claim 1, further comprising an anesthetic. 5. The standardized bee venom preparation of claim 4, wherein said anesthetic is selected from the group consisting of ambucaine, amolanone, amylocaine hydrochloride, benoxinate, benzocaine, betoxycaine, biphenamine, bupivacaine, butacaine, butamben, butanilicaine, butethamine, butoxycaine, carticaine, chloroprocaine hydrochloride, cocaethylene, cocaine, cyclomethycaine, dibucaine hydrochloride, dimethisoquin, dimethocaine, diperodon hydrochloride, dyclonine, ecgonidine, ecgonine, ethyl chloride, etidocaine, β eucaine, euprocin, fenalcomine, fomocaine, hexylcaine hydrochloride, hydroxytetracaine, isobutyl p aminobenzoate, leucinocaine mesylate, levoxadrol, lidocaine, mepivacaine, meprylcaine, metabutoxycaine, methyl chloride, myrtecaine, naepaine, octacaine, orthocaine, oxethazaine, parethoxycaine, phenacaine hydrochloride, phenol, piperocaine, piridocaine, polidocanol, plidocanol, pramoxine, prilocaine, procaine, propanocaine, proparacaine, propipocaine, propoxycaine hydrochloride, pseudococaine, pyrrocaine, ropivacaine, salicyl alcohol, tetracaine hydrochloride, tolycaine, trimecaine, zolamine, and mixtures thereof. 6. The standardized bee venom preparation of claim 4, wherein said anesthetic is lidocaine. 7. The standardized bee venom preparation of claim 4, wherein the amount of said anesthetic provided is in a ratio of between about 20:1 to about 1:10 by weight relative to the weight of said standardized bee venom preparation. 8. The standardized bee venom preparation of claim 7, wherein the amount of said anesthetic provided is in a ratio of between 10:1 to about 1:5 by weight relative to the weight of said standardized bee venom preparation. 9. The standardized bee venom preparation of claim 8, wherein the amount of said anesthetic provided is in a ratio of between 3:1 to about 1:1 by weight relative to the weight of said standardized bee venom preparation. 10. A method of treating rheumatoid, osteoarthritis, gouty arthritis, psoriatic arthritis, psoriasis, ankylosing spondylitis, fibromyalgia, fibromyositis, myofascial dysfunction pain syndrome, tennis elbow, golfer's elbow, frozen shoulder, bursitis, tendonitis, chronic surgical inflammation of soft and bony tissue, peripheral neuritis, neuralgia, migraine, eczema, multiple sclerosis or lupus comprising administering the standardized bee venom preparation of claim 1 to a patient in need thereof. 11. The method of claim 10, wherein the standardized bee venom preparation of claim 1 is administered to the patient via the intradermal, intramuscular, subdermal or subcutaneous route.
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이 특허에 인용된 특허 (7)
Robson Charles H. (6241 S. 30th St. Phoenix AZ 85040), Bee venom collection apparatus.
Dhaliwal Avtar S. (Ste. 43 ; 408 State of Franklin Rd. Johnson City TN 37604) Masih Shabir Z. (Ste. 43 ; 408 State of Franklin Rd. Johnson City TN 37604), Composite anesthetic article and method of use.
Tsay Yuh-Geng (San Jose CA) Beigler Myron A. (Los Altos Hills CA) Calenoff Emanuel (Burlingame CA) Friesen Gerald L. (Vacaville CA) Nichols James L. (Los Altos CA), Stable allergenic extracts and methods.
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