Abstract ▼

Forty five kinds of isoflavonoids and flavonoids were isolated from the traditional food materials including soybean. They were identified by the aid of spectral analyses such as H-NMR, C-NMR and mass. All the isolated components were evaluated for the inhibitory activity on the proliferation of cul

Forty five kinds of isoflavonoids and flavonoids were isolated from the traditional food materials including soybean. They were identified by the aid of spectral analyses such as H-NMR, C-NMR and mass. All the isolated components were evaluated for the inhibitory activity on the proliferation of cultured human tumor cell lines such as A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon) in vitro, respectively. The structure activity relationship was investigated.
Five kinds of polyphenol (tea polyphenol ; catechin, epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate) were purified from the leaf extract of green tea. The optimal HPLC conditions were developed and the pattern analysis of many tea products were executed, which could be employed as a standardized analysis tool of tea products.

목차 Contents

• 제 1 장 연구개발과제의 개요...8
• 제 1 절 연구개발의 목적...8
• 제 2 절 연구개발의 필요성...8
• 제 3 절 연구개발의 범위...9
• 제 2 장 국내외 기술개발현황...10
• 제 1 절 국외 기술개발현황...10
• 제 2 절 국내기술개발현황...10
• 제 3 장 연구개발수행내용 및 결과...12
• 제 1 절 Flavonoid류들의 분리정제 및 항암활성에 따른 구조활성간의 관계...12
• 제 2 절 녹차의 카테친류 분석방법 및 패턴분석...22
• 제 3 절 도라지사포닌들의 분리정제 및 분석방법...36
• 제 4 장 목표 달성도 및 관련분야에의 기여도...43
• 제 5 장 연구개발결과의 활용계획...43
• 제 6 장 연구개발과정에서 수집한 해외과학기술정보...44
• 제 7 장 참고문헌...44