초록 ▼

우리 나라 사람 체내의 비소 함유실태를 조사하기 위해 국립과학수사연구소에 부검 의
뢰된 한국인 성인 사체(19-64세) 43구의 장기조직(간장 폐 신장피질 대뇌， 근육 및 피부)
중에 함유된 비소의 함량을 성별， 지역별 및 연령별로 구분하여 측정한다. 따로 변사자의 사
망원인 및 병리조직 둥을 통하여 질병으로 사망한 사람은 시료에서 제외한다
▶장기조직 중 비소의 분석법 확립
▶한국인 장기조직 중의 비소의 함유실태조사
▶비소의 인체 총노출량 추정조사
▶ 성별， 지역별 및 연령별 한국인 체내 함유량

우리 나라 사람 체내의 비소 함유실태를 조사하기 위해 국립과학수사연구소에 부검 의
뢰된 한국인 성인 사체(19-64세) 43구의 장기조직(간장 폐 신장피질 대뇌， 근육 및 피부)
중에 함유된 비소의 함량을 성별， 지역별 및 연령별로 구분하여 측정한다. 따로 변사자의 사
망원인 및 병리조직 둥을 통하여 질병으로 사망한 사람은 시료에서 제외한다
▶장기조직 중 비소의 분석법 확립
▶한국인 장기조직 중의 비소의 함유실태조사
▶비소의 인체 총노출량 추정조사
▶ 성별， 지역별 및 연령별 한국인 체내 함유량 조사

Abstract ▼

Trace elements in the body may be divided into two classes depending on whether
or not levels are maintained by some biological process. Where levels are maintained,
the elements are essential. The others, due to contamination from food or environment,
are termed nonessential. Because the h

Trace elements in the body may be divided into two classes depending on whether
or not levels are maintained by some biological process. Where levels are maintained,
the elements are essential. The others, due to contamination from food or environment,
are termed nonessential. Because the heavy metal concentrations in human body may
vary with the food or environment, it is very difficult to establish the standard values
or range of standard values for heavy metals in human tissues.
Arsenic is a ubiquitous element that ranks 20th in abundance in the earth's crust,
14th in the sea water, and is a component of several hundred minerals. Arsenic and its
compounds are mobile in the environment. Weathering of rocks converts arsenic sulfides
to arsenic trioxide, which enters the arsenic cycle as dust or by dissolution in rain,
rivers or groundwater. So, groundwater contamination by arsenic is a serious threat to
mankind allover the world. It can also enter food chain. Humans are exposed to this
toxic arsenic from air, food and water. The current study was performed to investigate
the levels of arsenic(As) in the internal organs Oiver, kidney cortex, lung, cerebrum,
abdominal muscle and abdominal skin) and to find out correlation with age and
interrelationship between tissues in Korean human bodies who had lived in Seoul or
Kyonggi do and Honam district. The tissues from 43 Korean cadavers were digested
with microwave digestion system and arsenic was determined by inductively coupled
plasma mass spectrometerOCP-MS). The mean recovery percentages of arsenic in liver
were about SO% and arsenic concentrations in human tissues were almost uniform. The
mean level of arsenic in internal tissues were as follow; liver 44.556±25.199ppb, kidney
cortex 42.652 ± 22.0S2ppb, lung 31.020 ± 17.504ppb, cerebrum 35.703 ± 22.591ppb, muscle
43.415±26.619ppb and skin 42.106 ± 25.S31ppb. No significant difference was found in the
levels of arsenic between sexes. And significant differences between districts where they
had lived were found in all tissues tested. The levels of arsenic in the tissues of
cadavers who had lived in Seoul Kyonggi do were higher than that of Honam district.
And Positive correlation with age was observed only in the cerebrum(p<0.05). A
significantly high correlations between tissues were observed in all tissues tested. This
result also shows that the distribution of arsenic is uniform in internal tissues.

목차 Contents

• 표지 ...1
• 최종보고서 ...2
• 제출문 ...4
• 요약문 ...5
• Summary ...7
• 목차 ...8
• I. 서 론 ...9
• II. 국내.외 기술 개발 현황 ...11
• III. 연구 개발수행 내용 및 결과 ...12
• 1. 재료 및 방법 ...12
• 2. 결과 ...16
• 3. 결론 ...25
• IV. 연구 개발목표 달성도 및 대외기여도 ...26
• 1. 연구내용 ...26
• 2. 달성도 ...26
• V. 연구 개발결과의 활용성과 및 계획 ...26
• 가. 계량적 성과 ...26
• 나. 성과내용기술 ...26
• 다. 활용계획 ...26
• VI. 기타 중요변경사항 ...27
• VII. 참고문헌 ...27
• 연구(세부)과제 요약 ...30