Abstract ▼

1. Background and Necessity of Research and Development Project
Human genome is estimated to approximately 100.000 pieces. Focusing on the developed countries, China is already a complete nucleotide sequence of the human genome by gene-related research in the direction of the new millennium is pr

1. Background and Necessity of Research and Development Project
Human genome is estimated to approximately 100.000 pieces. Focusing on the developed countries, China is already a complete nucleotide sequence of the human genome by gene-related research in the direction of the new millennium is presented. Information about gene function and the current Very few of these genes are known to come to study the function of the century has been emerging as a key research direction. Analysis of gene function in the human desire to understand the physiological phenomenon started in addition to being the ultimate human Direction, which addresses the human disease by better all want to enjoy a healthy life that is based on the desire.
2. Technical developments at home and abroad
- PAC-1 and P-selectin (CD62P) of platelet to cover the diagnosis and the progression of Alzheimer's disease can be expected to know.
- Cheon-an Oriental Medical Center, neurodegenerative disease drug released from the degenerative brain disease.
- The study of the drug to treat brain tumors progress.
- blood-brain barrier can pass directly through the drug carrier composition of the tumor confirmed the possibility of drug injection.
- Stroke lesions with neural circuits in the area discovered that inhibition through GABA.
- Schizophrenia as a neurodevelopmental disorder and treatment of the possibility of exploring a new definition.
3. Perform research and development qualities and results
(1) Brain nervous system diseases have a sample.
(2) Based research for the brain disease animal model.
- Cloning of transcription sites of PLC-δ1~4
- gene expression abnormalities in Brain tissue and cell line identified by proteomics.
- Production and Validation of animal models of Parkinson's.
- Production and Validation of animal models of epilepsy.
- Production and Validation of animal models of electric shock.
- Production and Validation of animal models of febrile seizures.
(3) Human Bone Marrow Mesenchymal Stem Cells induced to differentiate into vascular cells.
(4) Analysis of the genetic variation frequently brain disorders
- Analysis by CGH-array (Parkinson's disease, Epilepsy, Schizophrenia, stroke, Aneurysm, Variant angina, Aortic dissection, Takayasu)
- Analysis by SNP (stroke)
(5) Study on personalized medicine
- Fluoxetine
- Venlafaxine
3. Use planning
(1) Secure sample of related - brain nervous system and clinical data
- Genome-related research in more depth than ever before possible with the previously established samples on program for the registration of brain nervous patients.
(2) Analysis of the genetic variation frequently brain disorders
- Analysis of the genetic variation of brain nervous system diseases were the causes of the truths of a foot and analysis of the relationship between each disease, the diagnosis of the disease will be able to improve the accuracy.
And we are expected to be able to achieve economical and effective personalized treatment with the establishment of individual genetic variation research.

목차 Contents

• 1. 겉표지 (앞면) ...1
• I. 총 괄 현 황 ...3
• 2. 제출문 ...4
• 3. 보고서 요약서 ...5
• 4. 요약문 (한글) ...6
• 5. 요약문 (영문) ...8
• 6. 연구 성과 실적 및 향후 계획 ...10
• 7. 참여연구원 현황표 ...49
• II. 총괄연구과제 연구결과 ...50
• 1. 연구개발과제의 배경 및 필요성 ...51
• 2. 국내외 기술개발 현황 ...57
• 3. 연구개발과제의 추진체계 ...57
• 4. 연구개발수행 내용 및 결과 ...60
• 5. 목표달성도 및 관련분야 기여도 ...66
• 6. 향후 연구성과 추진 계획 ...69
• 7. 연구개발결과의 파급효과 ...69
• 8. 연구개발결과의 활용계획 ...71
• 9. 연구개발과정에서 수집한 해외과학기술정보 ...71
• 10. 참고문헌 ...71
• III. 제 ○세부 연구과제 ...72
• 1. 연구개발과제의 목표 ...73
• 2. 연구개발과제의 추진체계 ...74
• 3. 연구개발수행 내용 및 결과 ...74
• 4. 참고문헌 ...101
• IV. 제 3세부 연구과제 연구결과 ...102
• 1. 연구개발과제의 목표 ...103
• 2. 연구개발과제의 추진체계 ...106
• 3. 연구개발수행 내용 및 결과 ...107
• 4. 참고문헌 ...113
• V. 제 4 세부 연구과제 ...114
• 1. 연구개발과제의 목표 ...115
• 2. 연구개발과제의 추진체계 ...117
• 3. 연구개발수행 내용 및 결과 ...118
• 4. 참고문헌 ...130
• VI. 제 5 세부 연구과제 연구결과 ...131
• 1. 연구개발과제의 목표 ...132
• 2. 연구개발과제의 추진체계 ...133
• 3. 연구개발수행 내용 및 결과 ...133
• 4. 참고문헌 ...148
• VII. 첨부서류 ...149
• 목차 ...150
• 1. 자체평가의견서 ...151
• 2. 실적 증빙자료 ...156