초록 ▼

필요성 및 목표
○ 약물대사유전자 염기서열의 차이로 동일한 의약품을 복용하여도 개인 간 약물반응이 다르게 나타남
○ 한국인을 위한 개인맞춤약물요법을 실현하기 위해 한국인에서 약물유전형과 다양한 약물의 반응에 대한 정보 마련이 필요함
방법 및 결과
○ 외국의 개인맞춤약물 사례 조사·분석
○ 약물반응에 영향을 미치는 유전다형에 관한 조사
- Drug metabolism, distribution 등에 개인간 차이를 발생시키는 유전자 및 유전다형 조사·분석
○ 유전다형과 약물반응 분석
- 유전형

필요성 및 목표
○ 약물대사유전자 염기서열의 차이로 동일한 의약품을 복용하여도 개인 간 약물반응이 다르게 나타남
○ 한국인을 위한 개인맞춤약물요법을 실현하기 위해 한국인에서 약물유전형과 다양한 약물의 반응에 대한 정보 마련이 필요함
방법 및 결과
○ 외국의 개인맞춤약물 사례 조사·분석
○ 약물반응에 영향을 미치는 유전다형에 관한 조사
- Drug metabolism, distribution 등에 개인간 차이를 발생시키는 유전자 및 유전다형 조사·분석
○ 유전다형과 약물반응 분석
- 유전형별 피험자 모집
- 대상의약품 투여 후 PK and/or PD 분석
○ 한국인 개인맞춤약물 정보 발굴
- 유전형과 약물반응 상관성 분석
기대성과
○ 개인의 약물유전정보를 이용한 안전한 의약품 사용방안 마련
○ 한국인 개인맞춤약물요법 개발을 위한 과학적 근거 마련

Abstract ▼

For the treatment of diseases that people are taking drugs into the body by drug-metabolizing enzymes and drug metabolism, respectively. An enzyme that metabolizes the drug, and encrypt them the relevant receptors are expressed by the gene. Drug-metabolizing enzymes and transporters in a single nucl

For the treatment of diseases that people are taking drugs into the body by drug-metabolizing enzymes and drug metabolism, respectively. An enzyme that metabolizes the drug, and encrypt them the relevant receptors are expressed by the gene. Drug-metabolizing enzymes and transporters in a single nucleotide polymorphism of the gene sequences (SNP; Single Nucleotide Polymorphism), CNV (Copy Number Variation, gene insertion, deletion, duplication), and due to the impact of diversity and has a very different person each time. The single nucleotide polymorphism in the human genome sequencing each piece 300 , CNV is about 12% of the entire genome is known, and appears in the. This wide range of drug metabolizing enzyme gene genotype differences in drug response to differences in each person is displayed. Drug metabolism genes associated with more than half of the approximately 170 species of polymorphic (polymorphic) has. Drug-metabolizing enzyme gene polymorphism with drug-metabolizing enzyme is an enzyme generated by the function and expression pattern of the different drugs in vivo absorption, metabolism, distribution, and excretion(ADME) affects aspect.
Altered pharmacokinetic and pharmacodynamic response to the body intended effects of drugs and other drug reactions(adverse reactions and efficacy differences) causes. Genomics past 30 years, with the development of drug inherited 'one medicine is applied to everyone " I thought that was the paradigm of drug use in recent years 'appropriate medication to the patient , the appropriate time, the appropriate dose of medication" side effects of the drug minimize and maximize the efficacy of the 'personalized drug therapy" is being changed. Drug according to drug response genotype of the individual differences in drug is also present in each genotype of race differences exist. Racial differences in drug response of the living environment , eating habits , and external factors such as cultural differences and internal factors , such as race -specific genotype interaction occurs between one of those racial differences in genotype thought to be the most likely cause . Due to racial differences in genotypic drug medications , such as drug reactions , depending on the degree of race appear differently depending on race because the drugs often used to separate Person-to-person , due to the interracial differences in drug genotypic differences in drug response according to the individuals who appear safe drug for use in medicine and research to ensure that genetic information is very important. Are developed to study the genetic information in the drug , so that drugs can be safely used to be a lot of effort to expand. Drug efficacy and minimize the side effects of drug therapy is to maximize the personalized drugs in Koreans drug response genotype and the resulting genetic information to study the Korean drug is safe by ensuring our people to use drugs , you must arrange the necessary environment there .In this study, influence on drug response and to investigate genotype, the genotype in Koreans drug to identify differences in drug response and personalized drug drugs available Koreans want to provide genetic information.

목차 Contents

• 표지 ... 1
• 자체연구개발과제 연차실적.계획서 ... 2
• 요약문 ... 3
• Summary ... 4
• 목차 ... 5
• 연구개발과제 연구결과 ... 6
• 제1장 연구개발과제의 개요 ... 6
• 제2장 총괄연구개발과제의 국내.외 연구개발 현황 ... 11
• 제3장 연구개발과제의 연구수행 내용 및 결과 ... 21
• 제4장 연구개발과제의 연구결과 고찰 및 결론 ... 61
• 제5장 연구개발과제의 목표달성도 및 관련분야에의 기여도 ... 61
• 제6장 연구개발과제 연구개발 결과 활용계획 ... 62
• 제7장 첨부서류 ... 64
• 끝페이지 ... 214