초록 ▼

○ 연구결과
1. 특이 생리활성을 가지는 국내 자생 천연물 library 250 여종 확보
2. 천연물로부터 합성 항균제인 안식향산, 파라벤 등에 비교할 만한, 강력한 항균력을 가지는 플라보노이드 추출 조성물 확보
3. 플라보노이드 추출 조성물로부터 바이오스킨테크의 고유 기술인 발효생물전환 기술을 적용하여 항균활성과 물성 및 관능이 최적화된 플라보노이드 추출 조성물 제조 기술 확립
4. 이러한 생물전환 플라보노이드 조성물을 이용하여 다양한 제품에 대한 제형적합성을 극대화 시킨 제형 최적화 기술 확립
5.

○ 연구결과
1. 특이 생리활성을 가지는 국내 자생 천연물 library 250 여종 확보
2. 천연물로부터 합성 항균제인 안식향산, 파라벤 등에 비교할 만한, 강력한 항균력을 가지는 플라보노이드 추출 조성물 확보
3. 플라보노이드 추출 조성물로부터 바이오스킨테크의 고유 기술인 발효생물전환 기술을 적용하여 항균활성과 물성 및 관능이 최적화된 플라보노이드 추출 조성물 제조 기술 확립
4. 이러한 생물전환 플라보노이드 조성물을 이용하여 다양한 제품에 대한 제형적합성을 극대화 시킨 제형 최적화 기술 확립
5. 상기 기술을 적용한 천연항균제 시제품을 제조하고 이것을 사양실험 사료에 적용실시
6. 육계, 산란계 사양실험으로부터 사료용 항생제를 대체할 만한 통계처리한 실험결과 확보

Abstract ▼

III. Procedures & Rsults
1. In vitro antimicrobial activity of domestic herb extract
In vitro antimicrobial activity of domestic herb extract was examined against 7 kinds of harmful microorganisms.
2. Dietary effects of domestic herb extract on growth performance and physiological response

III. Procedures & Rsults
1. In vitro antimicrobial activity of domestic herb extract
In vitro antimicrobial activity of domestic herb extract was examined against 7 kinds of harmful microorganisms.
2. Dietary effects of domestic herb extract on growth performance and physiological response in broiler chicken
This experiment was conducted using 750 1d-old Ross male broiler chicks to evaluated dietary effects of domestic herb extract on growth performance and physiological response. The chicks were divided into 5 groups and fed control diets (antibiotics medicated or non-medicated commercial diets) or tested diets (non-medicated diets containing 0.1, 0.3 or 0.5% domestic herb extract), for 5 weeks.
3. Dietary effects of domestic herb extract on laying performance and egg quality in laying hens
This experiment was conducted using 400 42 week-old Hy-Line Brown layers to evaluated dietary effects of domestic herb extract on laying performance and egg quality. The layer were divided into 4 groups and fed one of four diets containing 0.1, 0.3 or 0.5% domestic herb extract or devoid it (as control), for 6 weeks.
4. In vitro antimicrobial activity of domestic herb extract
The highest antimicrobial activity against S. aureus, KACC 10196 (S. aureus), KACC 10550 (L. monocytogenes), E. coli, Sal. Galinarium, Enterobacter spp. 및 KCTC 1925 (Ent. phoenicalicola) was found in domestic herb extract. This result support the notion that domestic herb extract may have a role as pharmaceuticals and preservatives.
5. Dietary effects of domestic herb extract on growth performance and physiological response in broiler chicken
The body weight gain and feed conversion ratio in groups fed diets containing 0.1% or 0.3% domestic herb extract were significantly improved as compared with those of non-medicated control group. The average ND and IB antibody titers in groups fed diets containing domestic herb extract were significantly increased than that of control. The number of coli form bacteria was significantly reduced by feeding of 0.3% or 0.5% domestic herb extract as compared with that of control. These results indicated that dietary domestic herb extract exerted a growth-promoting and immune-enhancing effects on broiler chicks.
6. Dietary effects of domestic herb extract on laying performance and egg quality in laying hens
The egg weights in groups fed diets containing domestic herb extract were significantly increased as compared with that of control, although there was no significant difference in egg production. Eggshell strength, thickness and yolk color were not influenced by dietary treatments. The average ND and IB antibody titers in groups fed diets containing domestic herb extract tended to be increased, but not significantly. The malondialdehyde contents in stored egg was significantly lowered by feeding domestic herb extract. The Haugh unit was linearly increased after 2 weeks of storage. These results suggested that dietary domestic herb extract has been demonstrated to delay lipid oxidation in eggs when used in laying hen diets.

목차 Contents

• 제출문 ... 1
• 요약문 ... 2
• SUMMARY ... 6
• CONTENTS ... 10
• 목차 ... 11
• 제 1 장 연구개발과제의 개요 ... 12
• 제 1 절 연구개발의 필요성 및 목적 ... 12
• 제 2 절 연구개발의 내용 및 범위 ... 15
• 제 2 장 국내외 기술개발 현황 ... 17
• 제 1 절 기술개발 현황 ... 17
• 제 2 절 국내외 기술개발 현황 ... 19
• 제 3 장 연구개발수행 내용 및 결과 ... 22
• 제 1 절 연구개발 수행 내용 ... 22
• 제 2 절 결과 및 고찰 ... 47
• 제 4 장 목표달성도 및 관련분야에의 기여도 ... 74
• 제 5 장 연구개발결과의 활용계획 ... 76
• 제 1절 타 연구분야에 대한 응용 ... 76
• 제 6 장 연구개발과정에서 수집한 해외과학기술정보 ... 77
• 제 1절 천연물질(주로 식물 추출물)의 생물학적 활성 ... 77
• 제 2절 가금에서의 성장 및 생리활성 개선 효과 ... 78
• 제 3절 양계산물의 품질 개선 효과 ... 78
• 제 7 장 참고문헌 ... 79
• 끝페이지 ... 84