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Kafe 바로가기주관연구기관 | 신라대학교 |
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연구책임자 | 최재석 |
참여연구자 | 박정빈 , 김지현 , 홍용기 , 오태식 , 김명섭 |
보고서유형 | 최종보고서 |
발행국가 | 대한민국 |
언어 | 한국어 |
발행년월 | 2017-02 |
과제시작연도 | 2015 |
주관부처 | 해양수산부 Ministry of Oceans and Fisheries |
과제관리전문기관 | 한국해양과학기술진흥원 Korea Institute of Marine Science & Technology promotion |
등록번호 | TRKO201800002353 |
과제고유번호 | 1525005164 |
사업명 | 수산실용화기술개발 |
DB 구축일자 | 2018-03-24 |
키워드 | 다슬기.향어.항당뇨.운동능력향상.건강기능식품.Freshwater aquaculture.Semisulcospira coreana.Cyprinus carpio rtudus.health functional food.antidiabetic.exersise performance. |
DOI | https://doi.org/10.23000/TRKO201800002353 |
주요 양식 민물고기 중 항당뇨활성을 보인 다슬기 가수분해물과 운동능력향상 활성을 보인 향어 열수추출물에 대한 생리활성 및 지표물질을 규명하고 임상시험을 실시하여 건강기능식품 소재로서의 가능성을 확인하였다.
(출처 : 보고서 요약서 3p)
This study was intended to investigate the biological activities of cultured freshwater fishes, to find out the active compounds from them, and finally develop the health-promoting neutraceuticals as a high value added materials.
The survey was performed to estimate the levels of pathogenic m
This study was intended to investigate the biological activities of cultured freshwater fishes, to find out the active compounds from them, and finally develop the health-promoting neutraceuticals as a high value added materials.
The survey was performed to estimate the levels of pathogenic microorganisms, antibiotic residues, and heavy metals in seven Korean freshwater aquaculture species including Anguilla japortica, Cyprinus carpio rtudus, Oncorhynchus my kiss, Pseudobagrus fulvidraco, Semisulcospira coreana, Silurus asotus, and Trionyxs sinensis. None of the ten foodbome pathogens tested in this study were found in any of the species collected from any of the aquaculture farms. Furthermore, no banned chemicals or antibiotic residues were found in any of the species collected from any of the aquaculture farms, except enrofloxacin, which was below guideline limits (0.1 mg/kg). Finally, no species had lead, cadmium, total arsenic, or total mercury concentrations above the Ministry of Food and Drug Safety (MSDF) guidelines (0.5, 0.5, 0.1, and 0.5 mg/kg, respectively). These results ensure the safety of freshwater aquaculture species and will be useful for developing consumption advisories of freshwater fishes.
The hot water extracts and protein hydrolysates from 7 kinds of freshwater fishes were prepared at optimum conditions (25h extraction and lOh hydrolysis with 3 kinds of proteases). The hygienic safety of freshwater fishes were confirmed through testing amounts of the anti-biotics and degree of microbial contamination. The biological activities including anti-oxidation, anti-hypertensive, anti-diabetic, anti-inflammatory activity, and exercise improvement activity were tested using in vivo and in vitro assays. In in vivo animal study, melanian snail protein hydrolysates (MPh) and yellow catfish protein hydrolysates (YPh) showed potent anti-diabetic and related complication ameliorating effects in HFD mice, through the increases of the modulating effects on the hepatic glucose enzyme activities, antioxidant and pancreatic lipid digestion enzymes. In addition, the hot water extract of leather carp Cyprinus carpio nudus (ECN) shown the improvement of exercise performance in mice. Accordingly, MPh, YPh, and ECN will be promise as new potent medicinal foods or ingredients for health-promoting.
Freshwater animal proteins have long been used as nutrient supplements. In this study, melanian snail (Semisulcospira libertina) protein hydrolysates (MPh) were shown to have antidiabetic and protective effects against liver and kidney damage in type II diabetic mice adapted to a 45% kcal high-fat diet (HFD). The hypoglycemic, hepatoprotective, and nephroprotective effects were analyzed after 12 weeks of continuous oral administration of MPh at 125, 250, and 500 mg/kg. Diabetic control mice showed increases in body weight, blood glucose, and insulin levels, with decreases in serum high-density lipoprotein (HDL) levels. In addition, increases in steatohepatitis regions, hepatocyte hypertrophy, and lipid droplet deposit-related renal tubular vacuolation degenerative lesions were detected, with marked expansion and hyperplasia of pancreatic islets, and increases in insulin- and glucagon-producing cells, insulin/glucagon cell ratios in the endocrine pancreas and hepatic lipid peroxidation, as well as decreased zymogen contents. Furthermore, deterioration of the endogenous antioxidant defense system was seen, with reduced glucose utilization related hepatic glucokinase (GK) activity and increases in hepatic gluconeogenesis-related glucose-6-phosphatase (G6pase) and phosphoenolpyruvate carboxykinase (PEPCK) activity. However, all of these diabetic complications were dose-dependently and significantly inhibited by oral treatment with MPh. In addition, marked dose-dependent inhibition of hepatic lipid peroxidation, depletion of the liver endogenous antioxidant defense system, and changes in hepatic glucose-regulating enzyme activities were also observed. The results of this study suggest that MPh shows potent antidiabetic effects, along with amelioration of related complications in type II diabetic mice. The overall effects of MPh at a dose of 125 mg/kg on HFD-induced diabetes and related complications were similar or more potent than that of metformin (250 mg/kg).
Obesity contributes to the etiologies of a variety of comorbid conditions, such as cardiovascular disease, hypertension, and type 2 diabetes. In the present study, the anti-obesity effects of yellow catfish protein hydrolysate (YPh) were observed in mice fed a 45% Kcal high fat diet (HFD) compared with those of mice treated with simvastatin. HFD control mice showed noticeable increases in body weight, whole-body and abdominal fat densities, periovarian and abdominal wall-deposited fat pad weight, blood total cholesterol (TC), triglycerides (TG), low-density lipoprotein, aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, and creatinine levels, as well as fecal TC and TG contents but decreased serum high density lipoprotein levels. In addition, increased periovarian and dorsal abdominally deposited fat pad thickness, adipocyte hypertrophy, the number of steatohepatitis regions, hepatocyte hypertrophy, and lipid droplet deposition-related renal tubular vacuolation degenerative lesions were detected along with increased hepatic lipid peroxidation and a deteriorated endogenous antioxidant defense system (glutathione, catalase, and super oxide dismutase). However, all of these obesity and related complications were dose-dependently and significantly inhibited after 84 days of continuous oral treatment with 125, 250, and 500 mg/kg YPh. In addition, the YPh dose-dependently inhibited hepatic lipid peroxidation and depleted the liver endogenous antioxidant defense system. Overall, the effects of 250 mg/kg YPh on HFD-induced obesity and related complications were similar or more potent than those of 10 mg/kg simvastatin. These results indicate that YPh is a promising new potent medicinal ingredient to treat obesity and related complications. Freshwater softshell turtle (Trionyx sinensis) extract has been used traditionally as a tonic soup, and to recover from physical fatigue. To support these claims, the forelimb grip strength of mice was measured after feeding a softshell turtle extract for 7 days. The T. sinensis extract significantly increased the grip strength to 1.25±0.07 N (P <0.01), which is 16.8% higher than the force on day 0. After exercising, the blood glucose levels in extract-fed mice were 202% higher and urea levels were 73% lower, which were both significantly different than the levels observed after control treatment. Lactate dehydrogenase was significantly higher by 314%, and glutathione peroxidase increased by 165%. In addition, the obesity markers, serum triglyceride and cholesterol, decreased to 62% and 49%, respectively, after mice were fed the extract. These data show that the T. sinensis extract provided more energy for forelimb exercise, prevented protein catabolism and muscle fatigue, and decreased the oxidative stress caused by an exhaustive workout.
The hot water extract of leather carp (Cyprinus carpio nudus) has been used as a nourishing tonic soup and as an aid for recovery from physical fatigue. In this study, we investigated the effect of leather carp extract on exercise performance in mice. Swimming endurance and forelimb grip strength were assessed following oral administration of the extract (once per day for 7 days) at a dose of 0.5 mg/10 ul/g body weight. After 7 days, mice given the leather carp extract had significantly greater swimming endurance [105 土 18 s (P〈0.05); 52% longer than day 0] and forelimb grip strength [1.18 土 0.05 Newton (P <0.01); 17% greater than day 0]. The extract increased muscle mass, but had little effect on body weight. Following the swimming exercise, blood glucose, glutathione peroxidase, and superoxide dismutase levels in extract-fed mice were significantly higher (145%, 131%, and 106%, respectively) than in the saline control group. Blood levels of high-density lipoprotein cholesterol were also significantly increased (128%) in mice given the extract compared to the controls. These results suggest that leather carp extract can improve physical exercise performance and prevent oxidative stress caused by exhaustive workouts.
To elucidate the anti-diabetic mechanism of Semisulcospira coreana, we evaluated the mRNA and protein expression levels of components in the IR-PI3K-Akt and mitogenic pathways using RT-PCR and western blot analyses. To obtain biologically active proteins and peptides, SC was extracted with distilled water for 25 h at 100℃.
Additionally, SC was enzymatically hydrolyzed for 0 - 10 h at 50℃ by Alcalase® to form SCA,with Protamex® to form SCP,and with a mixture of Alcalase® and Protamex® to form SCAP. The SCP and SCEP treatment increased the relative mRNA levels of IRS-1 and GLUT4 and decreased the relative mRNA levels of PTP1B. SCP10 and SCEP10 increased the relative protein expression levels of p-IR, p-Akt,and p42/44 MAPK. These results indicate that SCP10 and SCEP10 inhibited PTP1B activity and facilitated the IR-PI3K—Akt pathway and mitogenic pathways. These results support the use of SC as a functional natural resource for the prevention or treatment of diabetes mellitus.
To analyze effects of Cyprinus carpio nudus extract on exercise performance, double-blind, randomized, placebo controlled clinical study was performed. For this purpose, the efficacy and safety parameters on 40 healthy adults were evaluated before and after administration of the test food. In these results, control group was not significant at the visit 4. On the other hand, the test group showed a significant increase in the visit 4,in the comparison of the visits in the first analysis of validity variables of the PP analysis group. In addition, In the case of creatinine, which is one of the secondary efficacy variables, the creatinine of the test group was significantly increased in the intra-group comparison. Therefore, if we sufficiently extend the intake period, it is possible to improve the exercise performance.
In conclusion, these results will promote the consumption of freshwater fish and activate the freshwater fish-cultivating industry, providing the safety and biological activities of cultured freshwater fishes to consumers.
(출처 : SUMMARY 6p)
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