초록

본 연구는 흡연과 폐암발생 관련성에 대한 인종차이 원인분석을 목적으로 한 한국-영국 공동연구로 다음의 연구 성과를 도출함.
- 한국-영국 방문(각 2회/총 4회)을 통한 협력 네트워크 구축
- 석·박사과정생 양성을 위한 훈련(비교 분석방법 습득)
- 심포지엄 개최를 통한 결과발표
- SCI 논문 1편 게재
- 석사학위생 1명 배출

(출처 : 보고서 요약서 3p)

Abstract ▼

□ Purpose& Contents
Smoking is well-known to be one of the strongest independent risk factors for lung cancer, which caused 1.6 million deaths in 2012. However, the magnitude of the risk of lung cancer death in relation to cigarette smoking has been controversial.
The objectives of this study

□ Purpose& Contents
Smoking is well-known to be one of the strongest independent risk factors for lung cancer, which caused 1.6 million deaths in 2012. However, the magnitude of the risk of lung cancer death in relation to cigarette smoking has been controversial.
The objectives of this study are
1) To investigate whether the association of smoking and lung cancer differs between Asian and Western populations, and whether these differences can be explained by environmental or genetic factors, using large-scale data from Korea and the UK (two countries with different genetic and environmental exposures, this project);
2) To increase collaboration between UK and Korean researchers using data from existing large biobanks; and
3) To explore collaboration and exchanges between post-graduate students (Masters and Doctoral).

□ Results
1) The Korea-UK investigators visited each country (twice for each)
- Visits to UK by Korean researchers involved visits to Oxford University to : (1) learn about UK Biobank (UKB); (2) present the results from KCPS-I and KCPS-II cohorts at the Richard Doll Seminar; and (3) be trained in the statistical methods by researchers of the UKB.
- Visits to Korea by the UK researchers involved visiting to Yonsei University to : (1) hold seminars and lectures on the need for large-scale epidemiological studies and on the comparative outcomes obtained from the present project; (2) introduce different cohorts; and (3) discuss future collaborative research.
2) Comparative analyses of smoking and lung cancer risk
- Data from the UKB, KCPS-I, KCPS-II, the Korean National Health Insurance Study and the Korean Genome and Epidemiology Study (KoGES) were used to investigate age- and sex-specific smoking habits in each cohort and association between smoking and lung cancer.
3) Increased collaboration between Korean and UK researchers using data from existing large biobanks
- The final outcomes were presented by the researchers from both countries at the Symposium held in Seoul, Korea (April, 2018).

□ Expected Contribution
The collaboration between Oxford and Yonsei Universities initiated by Sun Ha Jee and Sarah Lewington has been strengthened and extended by the present project.
- Future collaborative work will involve comparative analyses of lung cancer risk by smoking amount and investigation of the ethnic differences by environment and genetic effects.

(출처 : SUMMARY 5p)

목차 Contents

• 표지 ... 1
• 제 출 문 ... 2
• 보고서 요약서 ... 3
• 국문 요약문 ... 4
• SUMMARY ... 5
• Contents ... 6
• 목차 ... 7
• 1. 연구(기획) 과제의 개요 ... 8
• 1-1. 연구개발 목적 ... 8
• 1-2. 연구개발의 필요성 ... 8
• 1-3. 연구개발 범위 ... 10
• 2. 국내외 기술개발 현황 ... 13
• 3. 연구(기획)수행 내용 및 결과 ... 15
• 4. 목표달성도 및 관련분야 기여도 ... 27
• 4-1. 목표달성도 ... 27
• 4-2. 관련분야 기여도 ... 27
• 5. 연구(기획) 결과의 활용계획 ... 28
• 6. 연구(기획)과정에서 수집한 해외과학기술정보 ... 28
• 7. 연구(기획) 성과의 보안등급 ... 28
• 8. 국가과학기술종합정보시스템에 등록한 연구시설·장비 현황 ... 29
• 9. 연구개발과제 수행에 따른 연구실 등의 안전조치 이행실적 ... 29
• 10. 연구개발과제의 대표적 연구실적 ... 29
• 11. 기타사항 ... 30
• 11-1.보안 등급의 분류 및 결정 사유 ... 30
• 11-2. 연구실 안전조치 이행계획 ... 30
• 12. 참고문헌 ... 32
• [별첨 2] 실적 증빙자료 ... 33
• [별첨 3] 일반인을 위한 보고서 요약서 ... 37
• 끝페이지 ... 38