초록 ▼

- 본초, 방제, chemical compound의 library 구축
- MT-HTS를 활용한 본초, 방제, compound 들의 간 주요세포별 효능평가
- 유효약물의 복합약리작용점 규명
- 생간건비탕, 감초건강탕, 작약감초탕, 해간전 등의 최적방제 도출
- 유효약물 및 최적방제의 독성 평가
- Chemical compound의 최적 조합 발굴
- 전문학술지 논문게재 : SCI(E) 197편, 비SCI(E) 43편
- 전문인력양성 : 박사 8, 석사 26
- 학술대회 학술발표 : 국제 6

- 본초, 방제, chemical compound의 library 구축
- MT-HTS를 활용한 본초, 방제, compound 들의 간 주요세포별 효능평가
- 유효약물의 복합약리작용점 규명
- 생간건비탕, 감초건강탕, 작약감초탕, 해간전 등의 최적방제 도출
- 유효약물 및 최적방제의 독성 평가
- Chemical compound의 최적 조합 발굴
- 전문학술지 논문게재 : SCI(E) 197편, 비SCI(E) 43편
- 전문인력양성 : 박사 8, 석사 26
- 학술대회 학술발표 : 국제 63건, 국내 124건, 수상 23건.
- 지식재산권 성과 : 출원17건, 등록 5건

(출처 : 보고서 요약서 3p)

Abstract ▼

□ Purpose
Herbal formulation (HF) based on Sovereign, Minister, Assistant and Courier theory is essential for both potentiating efficacy and reducing toxicity in oriental medicine. The goal of our center is to re-interpret HFs scientifically, identify potential drug targets to show synergic effi

□ Purpose
Herbal formulation (HF) based on Sovereign, Minister, Assistant and Courier theory is essential for both potentiating efficacy and reducing toxicity in oriental medicine. The goal of our center is to re-interpret HFs scientifically, identify potential drug targets to show synergic efficacy, optimize HFs, and evaluate in vivo efficacy and safety for the treatment of liver disease. Throughout MT-HTS and other core technologies, we will establish scientific basis to develop innovative drug by using herbs and its active compounds combination, which will lead to foster outstanding basic scientists for oriental medicine.

□ Contents
○ 1^st STAGE: Study for scientific rationale & optimization of HFs : We will screen HFs for liver disease through multi target-based high throughput screening system (MT-HTS), identify multi-drug targets, evaluate in vivo efficacy, safety and drugs interactions of HFs, thus providing a key to uncover the HF principle and the scientific basis of optimized HFs for liver disease.
Group #1: Establishment of multi-drug target and optimization for HFs
Group #2: Validation of in vivo efficacy and safety for HFs
○ 2^nd STAGE: Study for scientific rationale & optimization of innovative herbal formulation (IHF) and active compound combination (ACC) : Results from 1^st stage, we will optimize the combination of medicinal herbs and its active compounds based on MT-HTS and multi-drug targets, and then evaluate therapeutic efficacy and safety to provide scientific basis for clinical application.
GROUP #1: Establishment of multi-drug target and optimization for IHFs (/ACCs)
GROUP #2: Validation of in vivo efficacy and safety for IHFs (/ACCs)

□ Development results
- Establishment of herbs, herbal formulations and chemical compounds library
- Investigation of pharmacological effects of the libraries on hepatocytes, macrophages and hepatic stellate cells by MT-HTS
- Investigation of multiple drug target in effective herbs and herbal formulations
- Development of optimized herbal formulations
- Toxicity study of the effective herb and optimized herbal formulations
- Development of optimized chemical compound combinations
- Publication of research paper : SCI(E) 197, non-SCI(E) 43
- Professional manpower training : doctor degree 8, master degree 26
- Conference presentation : international 63, domestic 124, presentation award 23
- Patent : application 17, registration 5

□ Expected Contribution
The outcome of research center will assist in
○ providing the scientific rationale for the principle of herb combinations and its clinical application.
○ Fostering outstanding basic scientists with specialty in oriental medicine.
○ Strengthening public health and national competitiveness by transferring our results (herb, herbal formula and chemical compound) to medical industries.
○ Providing new therapeutic strategy for treatment of other chronic diseases.

(출처 : SUMMARY 5p)

목차 Contents

• 표지 ... 1
• 제 출 문 ... 2
• 보고서 요약서 ... 3
• 국문 요약문 ... 4
• SUMMARY ... 5
• 목차 ... 6
• Ⅰ 개요 ... 7
• 1. 목표 ... 7
• 2. 주요연혁 ... 13
• 3. 사업개요 ... 14
• 4. 조직 ... 18
• 5. 인력 현황 ... 20
• 6. 연구비 집행현황 ... 36
• Ⅱ 연구성과 ... 37
• 1. 연구성과 요약 ... 37
• 2. 사업수행 산출성과 ... 44
• 3. 기타 주요업적 ... 86
• Ⅲ 사업관리 및 기반구축 ... 93
• 1. 사업관리 ... 93
• 2. 설치대학의 지원실적 ... 97
• 3. 연구시설 기반구축 ... 100
• Ⅳ 목표달성도 ... 105
• 1. 목표달성도 ... 105
• 2. 대표 연구업적 ... 108
• 3. 센터 향후 연구계획 ... 114
• Ⅴ (NCRC만 작성)중·대분야간 융합분야 대학원 교육시스템 ... 115
• 1. 중·대분야간 융합분야 대학원 교육시스템 구축 ... 115
• 2. 중·대분야간 융합기술 전문연구인력 양성 실적 ... 116
• 3. 기타 인력양성 프로그램 수행 실적 ... 117
• 첨부 ... 118
• 끝페이지 ... 353