Abstract ▼ AI-Helper

The aim of this study was to investigate the anti-allergic effects of rose petal extracts in acute allergic reaction and ovalbumin-induced atopic dermatitis mouse model. White rose petal extract (WPRE) and red rose petal extract (RRPE) (10 - 100 mg/kg) inhibited systemic anaphylaxis induced by compo...

The aim of this study was to investigate the anti-allergic effects of rose petal extracts in acute allergic reaction and ovalbumin-induced atopic dermatitis mouse model. White rose petal extract (WPRE) and red rose petal extract (RRPE) (10 - 100 mg/kg) inhibited systemic anaphylaxis induced by compound 48/80 in a dose-dependent manner. The oral (300 mg/kg) or intraperitoneal (20 - 100 mg/kg) administration with WRPE decreased the local allergic reaction (passive cutaneous anaphylaxis, PCA) when activated by anti-dinitrophenyl (DNP) IgE. Buthanol fraction (WRPE-BtOH) and hexane (WRPE-hexane) fractions of WRPE showed high potents in inhibition of systemic and local anaphylatic reaction. In contrast, RRPE did not decrease the PCA reaction. Furthermore, orally administrated WRPE-hexane (320 mg/kg) significantly inhibited the vascular leakage of Evan's blue and scratching behavior induced by histamine. In addition, WRPE-hexane inhibited the β-hexosaminidase release from RBL-2H3 cells induced by PMA/ionomycin. For ovalbumin-induced atopic dermatitis model, female BALB/c mice were intraperitoneally sensitized with ovalbumin (10 ㎍) plus aluminuhydroxide (alum, 4 mg) three times weekly and, after 1 week, dermally challenged with patches containing ovalbumin (100 ㎍) for 2 weeks. WRPE was administrated intraperitoneally or orally once a day for 36 days. Intraperitoneal administration of WRPE (5 or 20 mg/kg) inhibited dermal lesions such as erythema/hemorrhage, edema, excoriation and dryness. In particular, oral administration of WRPE (300 mg/kg) markedly attenuated the symptoms as well as epidermal hyperplasia and infiltration of inflammatory cells including mast cells in dermis. In addition, WRPE significantly decreased serum IgE, histamine and interleukin-4 (IL-4) levels. Taken together, we concluded that WRPE could be a potential candidate for the anti- acute allergic responses and anti-chronic atopic dermatitis.

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